Renal pathology in adult and paediatric population of Japan: review of the Japan renal biopsy registry database from 2007 to 2017.
Adolescent
Adult
Aged
Child
Female
Humans
Male
Middle Aged
Young Adult
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
/ diagnosis
Antibodies, Antineutrophil Cytoplasmic
Biopsy
Glomerulonephritis
/ epidemiology
Glomerulonephritis, IGA
/ pathology
Glomerulonephritis, Membranous
/ diagnosis
IgA Vasculitis
Immunoglobulin A
Japan
/ epidemiology
Kidney
/ pathology
Nephrosis, Lipoid
/ pathology
Registries
Disease aetiology
Japan renal biopsy registry
Kidney biopsy
Renal pathology
Journal
Journal of nephrology
ISSN: 1724-6059
Titre abrégé: J Nephrol
Pays: Italy
ID NLM: 9012268
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
received:
21
12
2022
accepted:
17
05
2023
medline:
13
11
2023
pubmed:
19
8
2023
entrez:
19
8
2023
Statut:
ppublish
Résumé
The Japan Renal Biopsy Registry (J-RBR), a nationwide, web-based, registry system, started in 2007. This study aimed to summarise the epidemiology of biopsy-diagnosed kidney disease in Japan over 10 years. We analysed the J-RBR database, from 2007 to 2017. Patients' clinical data collected at the time of biopsy and histopathological diagnoses were used for epidemiological and clinicopathologic analyses. The predominant renal biopsy diagnoses were immunoglobulin A nephropathy (39.2%), lupus nephritis (6.5%) and minimal change disease (6.0%) in younger adults (19-64 years), and membranous nephropathy (17.4%), antineutrophil cytoplasmic antibody-associated vasculitis or anti-glomerular basement membrane glomerulonephritis (13.0%), and immunoglobulin A nephropathy (12.5%) in older adults (≥ 65 years). The percentages of patients diagnosed with membranoproliferative glomerulonephritis and immunoglobulin A nephropathy decreased, whereas those with immunoglobulin A vasculitis and diabetic nephropathy increased over the decade. In paediatric patients (< 19 years), immunoglobulin A nephropathy (36.1%), minimal change disease (17.6%), and immunoglobulin A vasculitis (8.6%) were the predominant diagnoses. The percentage of patients diagnosed with immunoglobulin A vasculitis increased over the decade. Based on the sex distribution, minimal change disease and membranous nephropathy were predominant in men aged < 20 and > 40 years, respectively, whereas immunoglobulin A vasculitis and antineutrophil cytoplasmic antibody-associated vasculitis or anti-glomerular basement membrane glomerulonephritis were predominant in women in their 20s and 30s and aged < 50 years, respectively. Immunoglobulin A nephropathy was predominant in men at most ages and in women in their 20s to 40s. This study describes the distribution and changes in kidney biopsy diagnoses over 10 years in Japan and paves the way for future research on kidney diseases in adults and children.
Sections du résumé
BACKGROUND
The Japan Renal Biopsy Registry (J-RBR), a nationwide, web-based, registry system, started in 2007. This study aimed to summarise the epidemiology of biopsy-diagnosed kidney disease in Japan over 10 years.
METHODS
We analysed the J-RBR database, from 2007 to 2017. Patients' clinical data collected at the time of biopsy and histopathological diagnoses were used for epidemiological and clinicopathologic analyses.
RESULTS
The predominant renal biopsy diagnoses were immunoglobulin A nephropathy (39.2%), lupus nephritis (6.5%) and minimal change disease (6.0%) in younger adults (19-64 years), and membranous nephropathy (17.4%), antineutrophil cytoplasmic antibody-associated vasculitis or anti-glomerular basement membrane glomerulonephritis (13.0%), and immunoglobulin A nephropathy (12.5%) in older adults (≥ 65 years). The percentages of patients diagnosed with membranoproliferative glomerulonephritis and immunoglobulin A nephropathy decreased, whereas those with immunoglobulin A vasculitis and diabetic nephropathy increased over the decade. In paediatric patients (< 19 years), immunoglobulin A nephropathy (36.1%), minimal change disease (17.6%), and immunoglobulin A vasculitis (8.6%) were the predominant diagnoses. The percentage of patients diagnosed with immunoglobulin A vasculitis increased over the decade. Based on the sex distribution, minimal change disease and membranous nephropathy were predominant in men aged < 20 and > 40 years, respectively, whereas immunoglobulin A vasculitis and antineutrophil cytoplasmic antibody-associated vasculitis or anti-glomerular basement membrane glomerulonephritis were predominant in women in their 20s and 30s and aged < 50 years, respectively. Immunoglobulin A nephropathy was predominant in men at most ages and in women in their 20s to 40s.
CONCLUSIONS
This study describes the distribution and changes in kidney biopsy diagnoses over 10 years in Japan and paves the way for future research on kidney diseases in adults and children.
Identifiants
pubmed: 37597092
doi: 10.1007/s40620-023-01687-9
pii: 10.1007/s40620-023-01687-9
pmc: PMC10638177
doi:
Substances chimiques
Antibodies, Antineutrophil Cytoplasmic
0
Immunoglobulin A
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2257-2267Subventions
Organisme : Japanese Society of Nephrology
ID : 20316943
Organisme : Childhood-onset, Rare, and Intractable Kidney Diseases in Japan, Research on Rare and Intractable Diseases, Health, Labour and Welfare Sciences Research Grants
ID : 20FC1028
Informations de copyright
© 2023. The Author(s).
Références
O’Shaughnessy MM, Hogan SL, Thompson BD, Coppo R, Fogo AB, Jennette JC (2018) Glomerular disease frequencies by race, sex and region: results from the International kidney biopsy survey. Nephrol Dial Transplant 33:661–669. https://doi.org/10.1093/ndt/gfx189
doi: 10.1093/ndt/gfx189
pubmed: 29106637
Hamano T, Imaizumi T, Hasegawa T, Fujii N, Komaba H, Ando M, Nangaku M, Nitta K, Hirakata H, Isaka Y, Wada T, Maruyama S, Fukagawa M (2022) Biopsy-proven CKD etiology and outcomes: chronic kidney disease Japan Cohort (CKD-JAC) study. Nephrol Dial Transplant. https://doi.org/10.1093/ndt/gfac134
doi: 10.1093/ndt/gfac134
pmcid: 9923708
Sugiyama H, Yokoyama H, Sato H, Saito T, Kohda Y, Nishi S, Tsuruya K, Kiyomoto H, Iida H, Sasaki T, Higuchi M, Hattori M, Oka K, Kagami S, Nagata M, Kawamura T, Honda M, Fukasawa Y, Fukatsu A, Morozumi K, Yoshikawa N, Yuzawa Y, Matsuo S, Kiyohara Y, Joh K, Taguchi T, Makino H, Committee for Standardization of Renal Pathological Diagnosis and Working Group for Renal Biopsy Database, Japanese Society of Nephrology, Tokyo, Japan (2011) Japan renal biopsy registry: the first nationwide, web-based, and prospective registry system of renal biopsies in Japan. Clin Exp Nephrol 15:493–503. https://doi.org/10.1007/s10157-011-0430-4
doi: 10.1007/s10157-011-0430-4
pubmed: 21437579
Yokoyama H, Sugiyama H, Sato H, Taguchi T, Nagata M, Matsuo S, Makino H, Watanabe T, Saito T, Kiyohara Y, Nishi S, Iida H, Morozumi K, Fukatsu A, Sasaki T, Tsuruya K, Kohda Y, Higuchi M, Kiyomoto H, Goto S, Hattori M, Hataya H, Kagami S, Yoshikawa N, Fukasawa Y, Ueda Y, Kitamura H, Shimizu A, Oka K, Nakagawa N, Ito T, Uchida S, Furuichi K, Nakaya I, Umemura S, Hiromura K, Yoshimura M, Hirawa N, Shigematsu T, Fukagawa M, Hiramatsu M, Terada Y, Uemura O, Kawata T, Matsunaga A, Kuroki A, Mori Y, Mitsuiki K, Yoshida H, Committee for the Standardization of Renal Pathological Diagnosis and for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology, and the Progressive Renal Disease Research of the Ministry of Health, Labour and Welfare of Japan (2012) Renal disease in the elderly and the very elderly Japanese: analysis of the Japan renal biopsy registry (J-RBR). Clin Exp Nephrol 16:903–920. https://doi.org/10.1007/s10157-012-0673-8
doi: 10.1007/s10157-012-0673-8
pubmed: 23053590
Sugiyama H, Yokoyama H, Sato H, Saito T, Kohda Y, Nishi S, Tsuruya K, Kiyomoto H, Iida H, Sasaki T, Higuchi M, Hattori M, Oka K, Kagami S, Kawamura T, Takeda T, Hataya H, Fukasawa Y, Fukatsu A, Morozumi K, Yoshikawa N, Shimizu A, Kitamura H, Yuzawa Y, Matsuo S, Kiyohara Y, Joh K, Nagata M, Taguchi T, Makino H, Committee for Standardization of Renal Pathological Diagnosis, Committee for Kidney Disease Registry, Japanese Society of Nephrology (2013) Japan renal biopsy registry and Japan kidney disease registry: committee report for 2009 and 2010. Clin Exp Nephrol 17:155–173. https://doi.org/10.1007/s10157-012-0746-8
doi: 10.1007/s10157-012-0746-8
pubmed: 23385776
Urushihara M, Sato H, Shimizu A, Sugiyama H, Yokoyama H, Hataya H, Matsuoka K, Okamoto T, Ogino D, Miura K, Hamada R, Hibino S, Shima Y, Yamamura T, Kitamoto K, Ishihara M, Konomoto T, Hattori M, The Committee for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology (2021) Clinical and histological features in pediatric and adolescent/young adult patients with renal disease: a cross-sectional analysis of the Japan renal biopsy registry (J-RBR). Clin Exp Nephrol 25:1018–1026. https://doi.org/10.1007/s10157-021-02077-w
doi: 10.1007/s10157-021-02077-w
pubmed: 34047871
Ozeki T, Maruyama S, Nagata M, Shimizu A, Sugiyama H, Sato H, Yokoyama H, Committee for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology (2020) The revised version 2018 of the nationwide web-based registry system for kidney diseases in Japan: Japan renal biopsy registry and Japan kidney disease registry. Clin Exp Nephrol 24:1058–1068. https://doi.org/10.1007/s10157-020-01932-6
doi: 10.1007/s10157-020-01932-6
pubmed: 32761468
pmcid: 7524691
Jin B, Zeng C, Ge Y, Le W, Xie H, Chen H, Liang S, Xu F, Jiang S, Liu Z (2014) The spectrum of biopsy-proven kidney diseases in elderly Chinese patients. Nephrol Dial Transplant 29:2251–2259. https://doi.org/10.1093/ndt/gfu239
doi: 10.1093/ndt/gfu239
pubmed: 25034755
Umemura S, Arima H, Arima S, Asayama K, Dohi Y, Hirooka Y, Horio T, Hoshide S, Ikeda S, Ishimitsu T, Ito M, Ito S, Iwashima Y, Kai H, Kamide K, Kanno Y, Kashihara N, Kawano Y, Kikuchi T, Kitamura K, Kitazono T, Kohara K, Kudo M, Kumagai H, Matsumura K, Matsuura H, Miura K, Mukoyama M, Nakamura S, Ohkubo T, Ohya Y, Okura T, Rakugi H, Saitoh S, Shibata H, Shimosawa T, Suzuki H, Takahashi S, Tamura K, Tomiyama H, Tsuchihashi T, Ueda S, Uehara Y, Urata H, Hirawa N (2019) The Japanese society of hypertension guidelines for the management of hypertension (JSH 2019). Hypertens Res 42:1235–1481. https://doi.org/10.1038/s41440-019-0284-9
doi: 10.1038/s41440-019-0284-9
pubmed: 31375757
Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, Yamagata K, Tomino Y, Yokoyama H, Hishida A, Collaborators developing the Japanese equation for estimated GFR (2009) Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis 53:982–992. https://doi.org/10.1053/j.ajkd.2008.12.034
doi: 10.1053/j.ajkd.2008.12.034
pubmed: 19339088
Uemura O, Nagai T, Ishikura K, Ito S, Hataya H, Gotoh Y, Fujita N, Akioka Y, Kaneko T, Honda M (2014) Creatinine-based equation to estimate the glomerular filtration rate in Japanese children and adolescents with chronic kidney disease. Clin Exp Nephrol 18:626–633. https://doi.org/10.1007/s10157-013-0856-y
doi: 10.1007/s10157-013-0856-y
pubmed: 24013764
Perkowska-Ptasinska A, Bartczak A, Wagrowska-Danilewicz M, Halon A, Okon K, Wozniak A, Danilewicz M, Karkoszka H, Marszalek A, Kowalewska J, Mroz A, Korolczuk A, Oko A, Debska-Slizien A, Naumnik B, Hruby Z, Klinger M, Ciechanowski K, Myslak M, Sulowicz W, Rydzewski A, Wiecek A, Manitius J, Gregorczyk T, Niemczyk S, Nowicki M, Gellert R, Stompor T, Wieliczko M, Marczewski K, Paczek L, Rostkowska O, Deborska-Materkowska D, Bogdanowicz G, Milkowski A, Durlik M, Polish Society of Nephrology (2017) Clinicopathologic correlations of renal pathology in adult population of Poland. Nephrol Dial Transplant 32:209–218. https://doi.org/10.1093/ndt/gfw365
doi: 10.1093/ndt/gfw365
Schena FP (1997) Survey of the Italian registry of renal biopsies. Frequency of the renal diseases for 7 consecutive years. The Italian Group of renal Immunopathology. Nephrol Dial Transplant 12:418–426. https://doi.org/10.1093/ndt/12.3.418
doi: 10.1093/ndt/12.3.418
pubmed: 9075118
Heaf J, Løkkegaard H, Larsen S (1999) The epidemiology and prognosis of glomerulonephritis in Denmark 1985–1997. Nephrol Dial Transplant 14:1889–1897. https://doi.org/10.1093/ndt/14.8.1889
doi: 10.1093/ndt/14.8.1889
pubmed: 10462267
Rivera F, López-Gómez JM, Pérez-García R, Spanish Registry of Glomerulonephritis (2002) Frequency of renal pathology in Spain 1994–1999. Nephrol Dial Transplant 17:1594–1602. https://doi.org/10.1093/ndt/17.9.1594
doi: 10.1093/ndt/17.9.1594
pubmed: 12198210
Rychlík I, Jancová E, Tesar V, Kolsky A, Lácha J, Stejskal J, Stejskalová A, Dusek J, Herout V (2004) The Czech registry of renal biopsies: Occurrence of renal diseases in the years 1994–2000. Nephrol Dial Transplant 19(12):3040–3049. https://doi.org/10.1093/ndt/gfh521
doi: 10.1093/ndt/gfh521
pubmed: 15507479
Rivera F, López-Gómez JM, Pérez-García R, Spanish Registry of Glomerulonephritis (2004) Clinicopathologic correlations of renal pathology in Spain. Kidney Int 66:898–904. https://doi.org/10.1111/j.1523-1755.2004.00833.x
doi: 10.1111/j.1523-1755.2004.00833.x
pubmed: 15327378
Moutzouris DA, Herlitz L, Appel GB, Markowitz GS, Freudenthal B, Radhakrishnan J, D’Agati VD (2009) Renal biopsy in the very elderly. Clin J Am Soc Nephrol 4:1073–1082. https://doi.org/10.2215/cjn.00990209
doi: 10.2215/cjn.00990209
pubmed: 19443626
pmcid: 2689880
Nair R, Bell JM, Walker PD (2004) Renal biopsy in patients aged 80 years and older. Am J Kidney Dis 44:618–626
doi: 10.1016/S0272-6386(04)00944-8
pubmed: 15384012
Braun N, Schweisfurth A, Lohöfener C, Lange C, Gründemann C, Kundt G, Gröne HJ (2011) Epidemiology of glomerulonephritis in Northern Germany. Int Urol Nephrol 43:1117–1126. https://doi.org/10.1007/s11255-011-9955-4
doi: 10.1007/s11255-011-9955-4
pubmed: 21505754
Coppo R, Gianoglio B, Porcellini MG, Maringhini S (1998) Frequency of renal diseases and clinical indications for renal biopsy in children (report of the Italian national registry of renal biopsies in children). Group of renal immunopathology of the Italian Society of pediatric nephrology and group of renal immunopathology of the Italian society of nephrology. Nephrol Dial Transplant 13:293–297. https://doi.org/10.1093/oxfordjournals.ndt.a027821
doi: 10.1093/oxfordjournals.ndt.a027821
pubmed: 9509437
Cho BS, Hahn WH, Cheong HI, Lim I, Ko CW, Kim SY, Lee DY, Ha TS, Suh JS (2013) A nationwide study of mass urine screening tests on Korean school children and implications for chronic kidney disease management. Clin Exp Nephrol 17:205–210. https://doi.org/10.1007/s10157-012-0672-9
doi: 10.1007/s10157-012-0672-9
pubmed: 23135862
Nie S, He W, Huang T, Liu D, Wang G, Geng J, Chen N, Xu G, Zhang P, Luo Y, Nie J, Xu X, Hou FF (2018) The spectrum of biopsy-proven glomerular diseases among children in China: a National, cross-sectional survey. Clin J Am Soc Nephrol 13:1047–1054. https://doi.org/10.2215/cjn.11461017
doi: 10.2215/cjn.11461017
pubmed: 29915132
pmcid: 6032591
Mohapatra A, Kakde S, Annapandian VM, Valson AT, Duhli N, Korula A, Matthai SM, Pulimood AB, David VG, Alexander S, Jacob S, Varughese S, Basu G, Tamilarasi V, John GT (2018) Spectrum of biopsy proven renal disease in South Asian children: two decades at a tropical tertiary care centre. Nephrology (Carlton) 23:1013–1022. https://doi.org/10.1111/nep.13160
doi: 10.1111/nep.13160
pubmed: 28846194
Krogsbøll LT, Jørgensen KJ, Grønhøj Larsen CG, Gøtzsche PC (2012) General health checks in adults for reducing morbidity and mortality from disease: cochrane systematic review and meta-analysis. BMJ 345:e7191. https://doi.org/10.1136/bmj.e7191
doi: 10.1136/bmj.e7191
pubmed: 23169868
pmcid: 3502745
Yoshimura R, Yamamoto R, Shinzawa M, Kataoka R, Ahn M, Ikeguchi N, Wakida N, Toki H, Moriyama T (2021) Associations of kidney tests at medical facilities and health checkups with incidence of end-stage kidney disease: a retrospective cohort study. Sci Rep Sci Rep 11:20717. https://doi.org/10.1038/s41598-021-99971-w
doi: 10.1038/s41598-021-99971-w
pubmed: 34702949
Kamei K, Nakanishi K, Ito S, Saito M, Sako M, Ishikura K, Hataya H, Honda M, Iijima K, Yoshikawa N, Japanese Pediatric IgA Nephropathy Treatment Study Group (2011) Long-term results of a randomized controlled trial in childhood IgA nephropathy. Clin J Am Soc Nephrol 6:1301–1307. https://doi.org/10.2215/cjn.08630910
doi: 10.2215/cjn.08630910
pubmed: 21493743
pmcid: 3109925
Park YH, Choi JY, Chung HS, Koo JW, Kim SY, Namgoong MK, Park YS, Yoo KH, Lee KY, Lee DY, Lee SJ, Lee JE, Chung WY, Hah TS, Cheong HI, Choi Y, Lee KS (2005) Hematuria and proteinuria in a mass school urine screening test. Pediatr Nephrol 20:1126–1130. https://doi.org/10.1007/s00467-005-1915-8
doi: 10.1007/s00467-005-1915-8
pubmed: 15947990
Haas M, Spargo BH, Wit EC, Meehan SM (2000) Etiologies and outcome of acute renal insufficiency in older adults: a renal biopsy study of 259 cases. Am J Kidney Dis 35:433–447. https://doi.org/10.1016/s0272-6386(00)70196-x
doi: 10.1016/s0272-6386(00)70196-x
pubmed: 10692269
Uezono S, Hara S, Sato Y, Komatsu H, Ikeda N, Shimao Y, Hayashi T, Asada Y, Fujimoto S, Eto T (2006) Renal biopsy in elderly patients: a clinicopathological analysis. Ren Fail 28:549–555. https://doi.org/10.1080/08860220600840165
doi: 10.1080/08860220600840165
pubmed: 17050237
Hu R, Quan S, Wang Y, Zhou Y, Zhang Y, Liu L, Zhou XJ, Xing G (2020) Spectrum of biopsy proven renal diseases in Central China: a 10-year retrospective study based on 34,630 cases. Sci Rep Sci Rep 10:10994. https://doi.org/10.1038/s41598-020-67910-w
doi: 10.1038/s41598-020-67910-w
pubmed: 32620914
Hirano D, Ishikawa T, Inaba A, Sato M, Shinozaki T, Iijima K, Ito S (2019) Epidemiology and clinical features of childhood-onset anti-neutrophil cytoplasmic antibody-associated vasculitis: a clinicopathological analysis. Pediatr Nephrol 34:1425–1433. https://doi.org/10.1007/s00467-019-04228-4
doi: 10.1007/s00467-019-04228-4
pubmed: 31076873
Kashtan CE (2007) Alport syndrome and the X chromosome: implications of a diagnosis of Alport syndrome in females. Nephrol Dial Transplant 22:1499–505. https://doi.org/10.1093/ndt/gfm024
doi: 10.1093/ndt/gfm024
pubmed: 17400558
O’Shaughnessy MM, Hogan SL, Poulton CJ, Falk RJ, Singh HK, Nickeleit V, Jennette JC (2017) Temporal and demographic trends in glomerular disease epidemiology in the Southeastern United States, 1986–2015. Clin J Am Soc Nephrol 12:614–623. https://doi.org/10.2215/cjn.10871016
doi: 10.2215/cjn.10871016
pubmed: 28325866
pmcid: 5383393
Fakhouri F, Frémeaux-Bacchi V, Noël LH, Cook HT, Pickering MC (2010) C3 glomerulopathy: a new classification. Nat Rev Nephrol 6:494–9. https://doi.org/10.1038/nrneph.2010.85
doi: 10.1038/nrneph.2010.85
pubmed: 20606628
Zink CM, Ernst S, Riehl J, Helmchen U, Gröne HJ, Floege J, Schlieper G (2019) Trends of renal diseases in Germany: review of a regional renal biopsy database from 1990 to 2013. Clin Kidney J 12:795–800. https://doi.org/10.1093/ckj/sfz023
doi: 10.1093/ckj/sfz023
pubmed: 31808446
pmcid: 6885677
Churg J, Sobin LH (1982) Renal disease: classification and Atlas of glomerular diseases. Igaku Shoin, Tokyo
Churg J, Bernstein J, Glassock RJ (1995) Renal disease: classification and atlas of glomerular diseases, 2nd edn. Igaku Shoin, Tokyo