Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.

Animals Mice Allosteric Regulation Colitis / chemically induced GTP-Binding Protein alpha Subunits, Gi-Go Inflammation / drug therapy Ketone Bodies Niacin / pharmacology Receptors, G-Protein-Coupled / agonists
BHB GPCR HCAR2 allosteric modulation anti-inflamation biased allosteric modulator cryo-EM ketone body receptor niacin structural biology

Journal

Molecular cell
ISSN: 1097-4164
Titre abrégé: Mol Cell
Pays: United States
ID NLM: 9802571

Informations de publication

Date de publication:
07 09 2023
Historique:
received: 22 02 2023
revised: 27 06 2023
accepted: 28 07 2023
medline: 11 9 2023
pubmed: 20 8 2023
entrez: 19 8 2023
Statut: ppublish

Résumé

Hydroxycarboxylic acid receptor 2 (HCAR2), modulated by endogenous ketone body β-hydroxybutyrate and exogenous niacin, is a promising therapeutic target for inflammation-related diseases. HCAR2 mediates distinct pathophysiological events by activating G

Identifiants

DOI: 10.1016/j.molcel.2023.07.030 PMID: 37597514
pubmed: 37597514
pii: S1097-2765(23)00605-6
doi: 10.1016/j.molcel.2023.07.030
pii:
doi:

Substances chimiques

GTP-Binding Protein alpha Subunits, Gi-Go EC 3.6.5.1
Ketone Bodies 0
Niacin 2679MF687A
Hcar2 protein, mouse 0
Receptors, G-Protein-Coupled 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3171-3187.e7

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests West China Hospital of Sichuan University has applied for a Chinese patent (accepting institution: State Intellectual Property Office [SIPO] in China, patent application number: 2023102433637) on the combination of compound 9n and niacin for the treatment of inflammation-related diseases.

Auteurs

Chang Zhao (C)

Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu 610212, Sichuan, China.

Heli Wang (H)

Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu 610212, Sichuan, China.

Ying Liu (Y)

Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.

Lin Cheng (L)

Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610000, Sichuan, China.

Bo Wang (B)

Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.

Xiaowen Tian (X)

Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu 610212, Sichuan, China.

Hong Fu (H)

Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu 610212, Sichuan, China.

Chao Wu (C)

Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu 610212, Sichuan, China.

Ziyan Li (Z)

Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu 610212, Sichuan, China.

Chenglong Shen (C)

Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu 610212, Sichuan, China.

Jingjing Yu (J)

Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu 610212, Sichuan, China.

Shengyong Yang (S)

Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu 610212, Sichuan, China.

Hongbo Hu (H)

Department of Rheumatology and Immunology, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, Sichuan, China.

Ping Fu (P)

Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.

Liang Ma (L)

Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China. Electronic address: liang_m@scu.edu.cn.

Chuanxin Wang (C)

Department of Clinical Laboratory, The Second Hospital of Shandong University, Jinan 250033, Shandong, China. Electronic address: cxwang@sdu.edu.cn.

Wei Yan (W)

Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu 610212, Sichuan, China. Electronic address: weiyan2018@scu.edu.cn.

Zhenhua Shao (Z)

Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu 610212, Sichuan, China. Electronic address: zhenhuashao@scu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Biased allosteric activation of ketone body...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Biased allosteric activation of ketone body...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Régulation allostérique › Biased allosteric activation of ketone body...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du côlon › Colite › Biased allosteric activation of ketone body...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines G hétérotrimériques › Sous-unités alpha des protéines G › Sous-unités alpha Gi-Go des protéines G › Biased allosteric activation of ketone body...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Biased allosteric activation of ketone body...
questionsmedicales.fr › Composés chimiques organiques › Cétones › Corps cétoniques › Biased allosteric activation of ketone body...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Acides nicotiniques › Acide nicotinique › Biased allosteric activation of ketone body...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Biased allosteric activation of ketone body...