Discovery of 5-sulfonyltetrazoles as neuroblastoma differentiation agents.
Differentiation
Heterocycle
High throughput screening
Library
Neuroblastoma
Journal
Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377
Informations de publication
Date de publication:
01 10 2023
01 10 2023
Historique:
received:
09
06
2023
revised:
06
08
2023
accepted:
16
08
2023
medline:
18
9
2023
pubmed:
20
8
2023
entrez:
19
8
2023
Statut:
ppublish
Résumé
Previously, we developed an innovative high-content screening (HCS) approach to quantify neuroblastoma cell differentiation based on neurite outgrowth, a morphological differentiation marker of neuroblastoma cells. Here, we report the utilization of this platform to identify 1-methyl-5-(ethylsulfonyl)-1H-tetrazole (3a) as a new neuroblastoma differentiation agent using the ChemBridge Diverset
Identifiants
pubmed: 37597697
pii: S0960-894X(23)00333-5
doi: 10.1016/j.bmcl.2023.129455
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
129455Subventions
Organisme : NCI NIH HHS
ID : R15 CA213199
Pays : United States
Organisme : NCI NIH HHS
ID : R15 CA227680
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.