Inhaled corticosteroids and risk of lower respiratory tract infection with
COPD Exacerbations
COPD Pharmacology
COPD epidemiology
Respiratory Infection
Journal
BMJ open respiratory research
ISSN: 2052-4439
Titre abrégé: BMJ Open Respir Res
Pays: England
ID NLM: 101638061
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
25
03
2023
accepted:
28
07
2023
medline:
21
8
2023
pubmed:
20
8
2023
entrez:
19
8
2023
Statut:
ppublish
Résumé
Use of inhaled corticosteroids (ICS) is common in patients with chronic obstructive pulmonary disease (COPD) and has been associated with an increased risk of pneumonia. To investigate if accumulated ICS use in patients with COPD, is associated with a dose-dependent risk of infection with This observational cohort study included 18 870 persons with COPD who were registered in The Danish Register of COPD. Linkage to several nationwide registries was performed.Exposure to ICS was determined by identifying all prescriptions for ICS, redeemed within 365 days prior to study entry. Main outcome was a lower respiratory tract sample positive for We found an increased, dose-dependent, risk of a lower respiratory tract sample with Our study shows a dose-dependent increased risk of infection with
Sections du résumé
BACKGROUND
Use of inhaled corticosteroids (ICS) is common in patients with chronic obstructive pulmonary disease (COPD) and has been associated with an increased risk of pneumonia.
OBJECTIVE
To investigate if accumulated ICS use in patients with COPD, is associated with a dose-dependent risk of infection with
METHODS
This observational cohort study included 18 870 persons with COPD who were registered in The Danish Register of COPD. Linkage to several nationwide registries was performed.Exposure to ICS was determined by identifying all prescriptions for ICS, redeemed within 365 days prior to study entry. Main outcome was a lower respiratory tract sample positive for
RESULTS
We found an increased, dose-dependent, risk of a lower respiratory tract sample with
CONCLUSION
Our study shows a dose-dependent increased risk of infection with
Identifiants
pubmed: 37597970
pii: 10/1/e001726
doi: 10.1136/bmjresp-2023-001726
pmc: PMC10441089
pii:
doi:
Substances chimiques
Adrenal Cortex Hormones
0
Types de publication
Observational Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: RBD reports having received payment for expert testimony. Remaining authors have no conflicts of interest.
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