The systemic immune response in Parkinson's disease: focus on the peripheral immune component.
B cells
T cells
monocytes
neurodegeneration
neuroimmune
neuroinflammation
neutrophils
α-synuclein
Journal
Trends in neurosciences
ISSN: 1878-108X
Titre abrégé: Trends Neurosci
Pays: England
ID NLM: 7808616
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
04
03
2023
revised:
19
05
2023
accepted:
24
07
2023
medline:
22
9
2023
pubmed:
20
8
2023
entrez:
19
8
2023
Statut:
ppublish
Résumé
During Parkinson's disease (PD), both the central nervous system (CNS) and peripheral nervous system (PNS) are affected. In parallel, innate immune cells respond early to neuronal changes and alpha-synuclein (α-syn) pathology. Moreover, some of the affected neuronal groups innervate organs with a relevant role in immunity. Consequently, not only microglia, but also peripheral immune cells are altered, resulting in a systemic immune response. Innate and adaptive immune cells may participate in the neurodegenerative process by acting peripherally, infiltrating the brain, or releasing mediators that can protect or harm neurons. However, the sequence of the changes and the significance of each immune compartment in the disease remain to be clarified. In this review, we describe current understanding of the peripheral immune response in PD and discuss the road ahead.
Identifiants
pubmed: 37598092
pii: S0166-2236(23)00165-0
doi: 10.1016/j.tins.2023.07.005
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
863-878Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests M.R.R. serves on the Editorial Boards of NPJ Parkinson’s Disease and Brain Research. The authors declare no other competing interest in relation to this work.