Disruption of Ebola NP
Ebola
biomolecular condensate
inclusion body
phase separation
viral replication organelle
Journal
Journal of molecular biology
ISSN: 1089-8638
Titre abrégé: J Mol Biol
Pays: Netherlands
ID NLM: 2985088R
Informations de publication
Date de publication:
15 10 2023
15 10 2023
Historique:
received:
04
01
2023
revised:
04
08
2023
accepted:
11
08
2023
medline:
2
10
2023
pubmed:
21
8
2023
entrez:
20
8
2023
Statut:
ppublish
Résumé
Viral inclusion bodies (IBs) are potential sites of viral replication and assembly. How viral IBs form remains poorly defined. Here we describe a combined biophysical and cellular approach to identify the components necessary for IB formation during Ebola virus (EBOV) infection. We find that the eNP
Identifiants
pubmed: 37598728
pii: S0022-2836(23)00352-2
doi: 10.1016/j.jmb.2023.168241
pii:
doi:
Substances chimiques
Nucleoproteins
0
Viral Regulatory and Accessory Proteins
0
nucleoprotein VP35, Ebola virus
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
168241Subventions
Organisme : NIAID NIH HHS
ID : P01 AI120943
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI123926
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI107056
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103422
Pays : United States
Organisme : NIGMS NIH HHS
ID : R24 GM136766
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI143292
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI148663
Pays : United States
Informations de copyright
Copyright © 2023. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.