Health effects of the New Nordic Renal Diet in patients with stage 3 and 4 chronic kidney disease, compared with habitual diet: a randomized trial.
24h urine phosphorus
New Nordic Renal Diet
acid base
blood pressure
chronic kidney disease
dietary intervention
low dietary protein
low dietary sodium
metabolic syndrome
proteinuria
weight loss
Journal
The American journal of clinical nutrition
ISSN: 1938-3207
Titre abrégé: Am J Clin Nutr
Pays: United States
ID NLM: 0376027
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
received:
26
04
2023
revised:
14
08
2023
accepted:
16
08
2023
medline:
6
11
2023
pubmed:
21
8
2023
entrez:
20
8
2023
Statut:
ppublish
Résumé
Chronic kidney disease (CKD) leads to an accumulation of waste products and causes adverse cardiometabolic effects. We investigated the health effects of the New Nordic Renal Diet (NNRD), a novel meal pattern reduced in phosphorus, protein, and sodium. A 26-wk randomized trial compared the NNRD with a habitual diet. The NNRD group received weekly home deliveries of food and recipes. Monthly study visits included fasting blood samples, 24-h urine samples, blood pressure, and anthropometric measurements. Intention-to-treat analysis used linear mixed-effects models. Sixty patients, mean estimated glomerular filtration rate (eGFR) 34 mL/min/1.73 m NNRD in moderate CKD reduces phosphorus excretion, proteinuria, systolic blood pressure, and weight, mainly by reducing abdominal fat. This trial was registered at clinicaltrials.gov as NCT04579315.
Sections du résumé
BACKGROUND
Chronic kidney disease (CKD) leads to an accumulation of waste products and causes adverse cardiometabolic effects.
OBJECTIVES
We investigated the health effects of the New Nordic Renal Diet (NNRD), a novel meal pattern reduced in phosphorus, protein, and sodium.
METHODS
A 26-wk randomized trial compared the NNRD with a habitual diet. The NNRD group received weekly home deliveries of food and recipes. Monthly study visits included fasting blood samples, 24-h urine samples, blood pressure, and anthropometric measurements. Intention-to-treat analysis used linear mixed-effects models.
RESULTS
Sixty patients, mean estimated glomerular filtration rate (eGFR) 34 mL/min/1.73 m
CONCLUSION
NNRD in moderate CKD reduces phosphorus excretion, proteinuria, systolic blood pressure, and weight, mainly by reducing abdominal fat. This trial was registered at clinicaltrials.gov as NCT04579315.
Identifiants
pubmed: 37598748
pii: S0002-9165(23)66078-2
doi: 10.1016/j.ajcnut.2023.08.008
pii:
doi:
Substances chimiques
Sodium
9NEZ333N27
Phosphorus
27YLU75U4W
Banques de données
ClinicalTrials.gov
['NCT04579315']
Types de publication
Randomized Controlled Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1042-1054Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.