Nod-like receptors in inflammatory arthritis.
Ankylosing Spondylitis
Gout
Nod-like Receptors
Pediatric Arthritis
Psoriatic Arthritis
Rheumatoid Arthritis
Journal
Biomedical journal
ISSN: 2320-2890
Titre abrégé: Biomed J
Pays: United States
ID NLM: 101599820
Informations de publication
Date de publication:
18 Aug 2023
18 Aug 2023
Historique:
received:
22
06
2023
revised:
11
08
2023
accepted:
15
08
2023
medline:
21
8
2023
pubmed:
21
8
2023
entrez:
20
8
2023
Statut:
aheadofprint
Résumé
Nod-like receptors (NLRs) are innate immune receptors that play a key role in sensing components from pathogens and from damaged cells or organelles. NLRs form signaling complexes that can lead to activation of transcription factors or effector caspases - by means of inflammasome activation - culminating in promoting inflammation. An increasing body of research supports the role of NLRs in driving pathogenesis of inflammatory arthritis, a collection of diseases that include rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and pediatric arthritis. In this review, we briefly discuss the main drivers of inflammatory arthritis diseases and dive into the evidence for - and against - various NLRs in driving these diseases. We also review the studies examining the use of NLR and inflammasome inhibitors as potential therapies for inflammatory arthritis.
Identifiants
pubmed: 37598797
pii: S2319-4170(23)00092-6
doi: 10.1016/j.bj.2023.100655
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100655Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have declared that no competing interests exist.