Promotion of oxidative phosphorylation by complex I-anchored carbonic anhydrases?
NADH dehydrogenase complex (complex I)
Oxidative Phosphorylation (OXPHOS)
carbonic anhydrase
endosymbiotic theory
mitochondria
mitochondrial evolution
Journal
Trends in plant science
ISSN: 1878-4372
Titre abrégé: Trends Plant Sci
Pays: England
ID NLM: 9890299
Informations de publication
Date de publication:
18 Aug 2023
18 Aug 2023
Historique:
received:
17
05
2023
revised:
12
07
2023
accepted:
19
07
2023
medline:
21
8
2023
pubmed:
21
8
2023
entrez:
20
8
2023
Statut:
aheadofprint
Résumé
The mitochondrial NADH-dehydrogenase complex of the respiratory chain, known as complex I, includes a carbonic anhydrase (CA) module attached to its membrane arm on the matrix side in protozoans, algae, and plants. Its physiological role is so far unclear. Recent electron cryo-microscopy (cryo-EM) structures show that the CA module may directly provide protons for translocation across the inner mitochondrial membrane at complex I. CAs can have a central role in adjusting the proton concentration in the mitochondrial matrix. We suggest that CA anchoring in complex I represents the original configuration to secure oxidative phosphorylation (OXPHOS) in the context of early endosymbiosis. After development of 'modern mitochondria' with pronounced cristae structures, this anchoring became dispensable, but has been retained in protozoans, algae, and plants.
Identifiants
pubmed: 37599162
pii: S1360-1385(23)00238-8
doi: 10.1016/j.tplants.2023.07.007
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests None declared by authors.