RNA circuits and RNA-binding proteins in T cells.
RNA-binding protein (RBP)
T cell
immunity
long noncoding RNA (lncRNA)
lymphocyte
Journal
Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
28
05
2023
revised:
13
07
2023
accepted:
17
07
2023
medline:
2
10
2023
pubmed:
21
8
2023
entrez:
20
8
2023
Statut:
ppublish
Résumé
RNA is integral to the regulatory circuits that control cell identity and behavior. Cis-regulatory elements in mRNAs interact with RNA-binding proteins (RBPs) that can alter RNA sequence, stability, and translation into protein. Similarly, long noncoding RNAs (lncRNAs) scaffold ribonucleoprotein complexes that mediate transcriptional and post-transcriptional regulation of gene expression. Indeed, cell programming is fundamental to multicellular life and, in this era of cellular therapies, it is of particular interest in T cells. Here, we review key concepts and recent advances in our understanding of the RNA circuits and RBPs that govern mammalian T cell differentiation and immune function.
Identifiants
pubmed: 37599172
pii: S1471-4906(23)00153-9
doi: 10.1016/j.it.2023.07.006
pii:
doi:
Substances chimiques
RNA
63231-63-0
RNA-Binding Proteins
0
Ribonucleoproteins
0
RNA, Messenger
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
792-806Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL107202
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL109102
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007334
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no conflict of interest.