Genetically determined circulating resistin concentrations and risk of colorectal cancer: a two-sample Mendelian randomization study.
Colorectal cancer
Genetic
Instrumental
Mendelian randomization
Resistin
Journal
Journal of cancer research and clinical oncology
ISSN: 1432-1335
Titre abrégé: J Cancer Res Clin Oncol
Pays: Germany
ID NLM: 7902060
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
28
06
2023
accepted:
16
07
2023
medline:
30
10
2023
pubmed:
21
8
2023
entrez:
20
8
2023
Statut:
ppublish
Résumé
Resistin, a novel pro-inflammatory protein implicated in inflammatory processes, has been suggested to play a role in colorectal development. However, evidence from observational studies has been inconsistent. Mendelian randomization may be a complementary method to examine this association. We conducted a two-sample Mendelian randomization to estimate the association between genetically determined circulating resistin concentrations and risk of colorectal cancer (CRC). Protein quantitative trait loci (pQTLs) from the SCALLOP consortium were used as instrumental variables (IVs) for resistin. CRC genetic summary data was obtained from GECCO/CORECT/CCFR (the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry), and FinnGen (Finland Biobank). The inverse variance weighted method (IVW) was applied in the main analysis, and other robust methods were used as sensitivity analyses. Estimates for the association from the two data sources were then pooled using a meta-analysis approach. Thirteen pQTLs were identified as IVs explaining together 7.80% of interindividual variation in circulating resistin concentrations. Based on MR analyses, genetically determined circulating resistin concentrations were not associated with incident CRC (pooled-IVW-OR per standard deviation of resistin, 1.01; 95% CI 0.96, 1.06; p = 0.67. Restricting the analyses to using IVs within or proximal to the resistin-encoding gene (cis-IVs), or to IVs located elsewhere in the genome (trans-IVs) provided similar results. The association was not altered when stratified by sex or CRC subsites. We found no evidence of a relationship between genetically determined circulating resistin concentrations and risk of CRC.
Identifiants
pubmed: 37599317
doi: 10.1007/s00432-023-05193-0
pii: 10.1007/s00432-023-05193-0
pmc: PMC10602946
doi:
Substances chimiques
Resistin
0
Types de publication
Meta-Analysis
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
14889-14900Informations de copyright
© 2023. The Author(s).
Références
Cancer Causes Control. 2015 Feb;26(2):257-268
pubmed: 25488827
J Clin Endocrinol Metab. 2007 Jun;92(6):2272-9
pubmed: 17374708
Sci Rep. 2019 Oct 23;9(1):15245
pubmed: 31645609
Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1291-3
pubmed: 17548700
PLoS Med. 2004 Nov;1(2):e45
pubmed: 15578112
Genet Epidemiol. 2016 Nov;40(7):597-608
pubmed: 27625185
J Biol Chem. 2001 Apr 6;276(14):11252-6
pubmed: 11278254
Biochem Biophys Res Commun. 2003 Jan 10;300(2):472-6
pubmed: 12504108
Diabetes. 2009 Mar;58(3):750-6
pubmed: 19074981
Nat Genet. 2019 Jan;51(1):76-87
pubmed: 30510241
PLoS One. 2010 Mar 16;5(3):e9718
pubmed: 20300528
Diabetologia. 2010 Feb;53(2):234-46
pubmed: 19727657
Nature. 2001 Jan 18;409(6818):307-12
pubmed: 11201732
Genet Epidemiol. 2013 Nov;37(7):658-65
pubmed: 24114802
Clin Chim Acta. 2015 Jan 1;438:46-54
pubmed: 25128719
Gut. 2021 Jul;70(7):1325-1334
pubmed: 33632709
J Immunol. 2005 May 1;174(9):5789-95
pubmed: 15843582
Int J Epidemiol. 2017 Dec 1;46(6):1985-1998
pubmed: 29040600
World J Gastroenterol. 2019 Aug 21;25(31):4383-4404
pubmed: 31496619
Epidemiology. 2017 Jan;28(1):30-42
pubmed: 27749700
Nat Genet. 2012 Mar 18;44(4):369-75, S1-3
pubmed: 22426310
Clin Chem Lab Med. 2007;45(7):899-902
pubmed: 17617035
Int J Epidemiol. 2013 Oct;42(5):1497-501
pubmed: 24159078
Clin Chim Acta. 2012 Apr 11;413(7-8):760-4
pubmed: 22296675
Cancer Sci. 2010 May;101(5):1286-91
pubmed: 20331631
Nat Commun. 2020 Oct 1;11(1):4930
pubmed: 33004804
Atherosclerosis. 2017 Apr;259:51-59
pubmed: 28286252
Stat Med. 2008 Jul 10;27(15):2745-9
pubmed: 18344186
Biomed Res Int. 2016;2016:7367485
pubmed: 27642602
PLoS Genet. 2008 May 09;4(5):e1000072
pubmed: 18464913
Int J Epidemiol. 2015 Apr;44(2):512-25
pubmed: 26050253
Res Synth Methods. 2010 Apr;1(2):97-111
pubmed: 26061376
Nat Metab. 2020 Oct;2(10):1135-1148
pubmed: 33067605
Hum Mol Genet. 2017 May 1;26(9):1770-1784
pubmed: 28334899
Int J Epidemiol. 2012 Oct;41(5):1383-93
pubmed: 23045203
Diabetologia. 2004 Mar;47(3):559-565
pubmed: 14740159
Wellcome Open Res. 2019 Nov 26;4:186
pubmed: 32760811
IARC Sci Publ. 2011;(163):143-61
pubmed: 22997860
Cancers (Basel). 2022 Nov 09;14(22):
pubmed: 36428592
Cancer Res. 2012 Jun 15;72(12):3029-37
pubmed: 22511581
Front Genet. 2020 Feb 28;11:157
pubmed: 32180801
Stat Med. 2015 Sep 20;34(21):2926-40
pubmed: 25950993