Palmitoylethanolamide counteracts high-fat diet-induced gut dysfunction by reprogramming microbiota composition and affecting tryptophan metabolism.
N-acylethanolamines
gut microbiota
gut-brain axis
obesity
serotonin
Journal
Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264
Informations de publication
Date de publication:
2023
2023
Historique:
received:
12
01
2023
accepted:
04
07
2023
medline:
21
8
2023
pubmed:
21
8
2023
entrez:
21
8
2023
Statut:
epublish
Résumé
Obesity is associated with gastrointestinal (GI) tract and central nervous system (CNS) disorders. High-fat diet (HFD) feeding-induced obesity in mice induces dysbiosis, causing a shift toward bacteria-derived metabolites with detrimental effects on metabolism and inflammation: events often contributing to the onset and progression of both GI and CNS disorders. Palmitoylethanolamide (PEA) is an endogenous lipid mediator with beneficial effects in mouse models of GI and CNS disorders. However, the mechanisms underlining its enteroprotective and neuroprotective effects still need to be fully understood. Here, we aimed to study the effects of PEA on intestinal inflammation and microbiota alterations resulting from lipid overnutrition. Ultramicronized PEA (30 mg/kg/die
Identifiants
pubmed: 37599675
doi: 10.3389/fnut.2023.1143004
pmc: PMC10434518
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1143004Informations de copyright
Copyright © 2023 Pirozzi, Coretti, Opallo, Bove, Annunziata, Comella, Turco, Lama, Trabace, Meli, Lembo and Mattace Raso.
Déclaration de conflit d'intérêts
AL declares that he has benefited from a fellowship supported by Epitech Group S.p.A. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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