Neurodevelopment and early pharmacological interventions in Fragile X Syndrome.
Fragile X syndrome
GABA
PI3K
clinical trials
mGluR
neurodevelopment
pharmacological interventions
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2023
2023
Historique:
received:
28
04
2023
accepted:
17
07
2023
medline:
21
8
2023
pubmed:
21
8
2023
entrez:
21
8
2023
Statut:
epublish
Résumé
Fragile X Syndrome (FXS) is a neurodevelopmental disorder and the leading monogenic cause of autism and intellectual disability. For years, several efforts have been made to develop an effective therapeutic approach to phenotypically rescue patients from the disorder, with some even advancing to late phases of clinical trials. Unfortunately, none of these attempts have completely succeeded, bringing urgency to further expand and refocus research on FXS therapeutics. FXS arises at early stages of postnatal development due to the mutation and transcriptional silencing of the Fragile X Messenger Ribonucleoprotein 1 gene (
Identifiants
pubmed: 37599992
doi: 10.3389/fnins.2023.1213410
pmc: PMC10433175
doi:
Banques de données
figshare
['10.6084/m9.figshare.23643210.v1']
Types de publication
Journal Article
Review
Langues
eng
Pagination
1213410Informations de copyright
Copyright © 2023 Milla, Corral, Rivera, Zuñiga, Pino, Nunez-Parra and Cea-Del Rio.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Neuron. 2013 Feb 20;77(4):696-711
pubmed: 23439122
Brain Sci. 2022 Feb 26;12(3):
pubmed: 35326270
Neuropsychopharmacology. 2018 Feb;43(3):503-512
pubmed: 28816242
Biochem Soc Trans. 2010 Apr;38(2):507-10
pubmed: 20298211
Proc Natl Acad Sci U S A. 1997 May 13;94(10):5395-400
pubmed: 9144248
J Neurosci. 2017 May 31;37(22):5447-5462
pubmed: 28450542
Cell. 2001 May 18;105(4):521-32
pubmed: 11371348
J Neurodev Disord. 2017 Jun 12;9:7
pubmed: 28616096
Proc Natl Acad Sci U S A. 2002 May 28;99(11):7746-50
pubmed: 12032354
Sci Rep. 2018 Nov 19;8(1):16970
pubmed: 30451888
Neurosci Biobehav Rev. 2021 Dec;131:792-805
pubmed: 34634357
Am J Med Genet B Neuropsychiatr Genet. 2008 Oct 5;147B(7):1253-7
pubmed: 18452182
Annu Rev Med. 2019 Jan 27;70:167-181
pubmed: 30365357
J Gen Physiol. 2020 Jun 1;152(6):
pubmed: 32275741
Sci Rep. 2016 Oct 10;6:34391
pubmed: 27721389
Neurotoxicology. 2007 Sep;28(5):931-7
pubmed: 17368774
Mol Psychiatry. 2019 Nov;24(11):1732-1747
pubmed: 29703945
J Neurosci. 2010 Jan 13;30(2):694-702
pubmed: 20071534
Psychoneuroendocrinology. 2012 Apr;37(4):509-18
pubmed: 21862226
Am J Med Genet. 1999 Apr 2;83(4):268-79
pubmed: 10208160
Stem Cells Transl Med. 2022 Jun 22;11(6):613-629
pubmed: 35556144
Pediatr Res. 1995 Nov;38(5):638-43
pubmed: 8552427
Trends Neurosci. 2004 May;27(5):262-9
pubmed: 15111008
Neuroscience. 1994 Aug;61(3):481-95
pubmed: 7969925
Sci Transl Med. 2012 Sep 19;4(152):152ra128
pubmed: 22993295
Cannabis Cannabinoid Res. 2019 Mar 13;4(1):3-9
pubmed: 30944868
J Neurosci. 2010 Nov 17;30(46):15616-27
pubmed: 21084617
Front Psychiatry. 2019 Nov 06;10:810
pubmed: 31780970
Neurobiol Dis. 2019 Jul;127:53-64
pubmed: 30771457
Neurobiol Dis. 2006 Feb;21(2):346-57
pubmed: 16199166
Mol Psychiatry. 2019 Sep;24(9):1248-1257
pubmed: 31089192
Epilepsy Curr. 2009 Jul-Aug;9(4):108-12
pubmed: 19693328
Neuron. 2016 Jan 20;89(2):248-68
pubmed: 26796689
J Neurodev Disord. 2020 Apr 22;12(1):12
pubmed: 32316911
Cell Rep. 2019 Sep 3;28(10):2581-2593.e5
pubmed: 31484070
Neuron. 2007 Dec 20;56(6):955-62
pubmed: 18093519
Brain Res. 2015 Jan 30;1596:22-30
pubmed: 25446451
J Neurosci. 2011 Apr 13;31(15):5693-8
pubmed: 21490210
Nature. 2015 Jul 9;523(7559):212-6
pubmed: 26030523
Int J Dev Neurosci. 2016 Nov;54:6-21
pubmed: 27530811
Front Neural Circuits. 2013 Aug 13;7:136
pubmed: 23964205
Nat Med. 2021 May;27(5):862-870
pubmed: 33927413
Front Cell Neurosci. 2014 Aug 25;8:245
pubmed: 25202236
Nat Med. 2005 Nov;11(11):1205-13
pubmed: 16227993
Glia. 2020 Mar;68(3):495-508
pubmed: 31626382
Neuron. 2015 Aug 19;87(4):699-715
pubmed: 26291156
Learn Mem. 2015 Jun 15;22(7):323-35
pubmed: 26077685
Genome Res. 2020 Mar;30(3):361-374
pubmed: 32179589
J Neurodev Disord. 2017 Aug 2;9(1):26
pubmed: 28764646
Nat Rev Neurosci. 2002 Sep;3(9):715-27
pubmed: 12209120
J Physiol. 2016 Jan 1;594(1):83-97
pubmed: 26427907
Cereb Cortex. 2000 Oct;10(10):1038-44
pubmed: 11007554
Proc Natl Acad Sci U S A. 2020 Dec 1;117(48):30400-30411
pubmed: 33199649
Neurobiol Dis. 2022 Jan;162:105577
pubmed: 34871737
Psychopharmacology (Berl). 2011 May;215(2):291-300
pubmed: 21181121
Genet Med. 2011 Jun;13(6):528-538
pubmed: 21430544
J Neurodev Disord. 2017 Jun 12;9:3
pubmed: 28616094
RNA Biol. 2021 Jul;18(7):972-987
pubmed: 32865115
Am J Med Genet A. 2004 Apr 1;126A(1):9-17
pubmed: 15039968
Int J Dev Neurosci. 2015 May;42:15-23
pubmed: 25681562
Glia. 2021 Oct;69(10):2349-2361
pubmed: 34110049
Int J Dev Neurosci. 2020 Apr;80(2):73-85
pubmed: 31910289
J Neurosci. 1997 Jul 1;17(13):5196-205
pubmed: 9185557
Neurobiol Dis. 2020 Aug;142:104959
pubmed: 32512151
Behav Brain Res. 2012 Apr 1;229(1):244-9
pubmed: 22285772
PLoS One. 2015 Jul 29;10(7):e0131486
pubmed: 26222316
Cereb Cortex. 2016 Dec;26(12):4574-4589
pubmed: 26428952
J Neurosci. 2005 Aug 31;25(35):8048-55
pubmed: 16135762
J Neurosci. 2004 Aug 18;24(33):7272-6
pubmed: 15317853
Science. 1991 May 24;252(5009):1097-102
pubmed: 2031184
Neuron. 2002 Sep 12;35(6):1015-7
pubmed: 12354392
Nature. 2014 Apr 10;508(7495):199-206
pubmed: 24695229
Trends Neurosci. 2004 Jul;27(7):370-7
pubmed: 15219735
Int J Neuropsychopharmacol. 2015 Mar 28;18(9):
pubmed: 25820841
Prog Neurobiol. 2013 Jul-Aug;106-107:1-16
pubmed: 23583307
Am J Med Genet A. 2004 Sep 1;129A(3):225-34
pubmed: 15326621
Brain Res. 2013 Nov 6;1537:69-78
pubmed: 24008143
J Neurodev Disord. 2016;8:1
pubmed: 26855682
J Child Adolesc Psychopharmacol. 2017 Dec;27(10):850-863
pubmed: 28475355
Nat Rev Drug Discov. 2018 Apr;17(4):280-299
pubmed: 29217836
Nat Commun. 2017 Nov 24;8(1):1776
pubmed: 29176664
Neuron. 2010 Feb 11;65(3):385-98
pubmed: 20159451
Science. 1991 May 24;252(5009):1179-81
pubmed: 2031189
Cell Rep. 2021 Apr 13;35(2):108991
pubmed: 33852833
Cell. 2014 May 8;157(4):869-81
pubmed: 24813610
J Neurophysiol. 2020 Dec 1;124(6):1766-1773
pubmed: 32997566
J Med Genet. 2009 Apr;46(4):266-71
pubmed: 19126569
Curr Opin Neurobiol. 1999 Jun;9(3):299-304
pubmed: 10395580
J Neurophysiol. 2006 May;95(5):3291-5
pubmed: 16452252
Cell Death Differ. 2005 Aug;12(8):1124-33
pubmed: 15947794
Nat Neurosci. 2021 Mar;24(3):331-342
pubmed: 33619405
Dev Neurosci. 2011;33(5):365-78
pubmed: 21893939
Neuroscience. 2002;111(3):693-8
pubmed: 12031354
Am J Med Genet. 2001 Jan 15;98(2):161-7
pubmed: 11223852
Mol Pharmacol. 2009 Jul;76(1):18-24
pubmed: 19351745
J Neurosci. 2008 May 14;28(20):5178-88
pubmed: 18480274
Trends Neurosci. 2007 Aug;30(8):425-31
pubmed: 17590448
Cell. 1994 Jul 15;78(1):23-33
pubmed: 8033209
Cell Cycle. 2015;14(18):2985-95
pubmed: 25790165
J Pharmacol Exp Ther. 2006 Mar;316(3):1351-9
pubmed: 16272218
Cell. 2001 Nov 16;107(4):477-87
pubmed: 11719188
Sci Rep. 2021 Aug 5;11(1):15897
pubmed: 34354107
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Aug 30;110:110307
pubmed: 33757860
Nat Neurosci. 2021 Oct;24(10):1377-1391
pubmed: 34413513
J Neurosci. 1997 Mar 1;17(5):1539-47
pubmed: 9030614
Int J Mol Sci. 2022 Feb 09;23(4):
pubmed: 35216055
Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4429-34
pubmed: 18332424
J Neurophysiol. 2014 Aug 15;112(4):890-902
pubmed: 24848467
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jun 8;84(Pt A):140-151
pubmed: 29481897
J Neurochem. 2012 May;121(4):672-9
pubmed: 22393900
Sci Rep. 2017 Nov 7;7(1):14653
pubmed: 29116166
J Neurosci. 2014 Jan 8;34(2):446-50
pubmed: 24403144
Neuron. 2019 Feb 20;101(4):648-661.e4
pubmed: 30679017
Epilepsia. 2010 Aug;51(8):1456-67
pubmed: 20132297
Acta Physiol Scand. 1996 May;157(1):1-19
pubmed: 8735650
Nature. 1999 Jan 21;397(6716):251-5
pubmed: 9930699
Transl Psychiatry. 2019 Nov 20;9(1):312
pubmed: 31748507
Sci Transl Med. 2016 Jan 13;8(321):321ra5
pubmed: 26764156
Sci Rep. 2018 Aug 2;8(1):11585
pubmed: 30072797
Biomarkers. 2016 Sep;21(6):497-508
pubmed: 27058300
Neuron. 2003 May 8;38(3):433-45
pubmed: 12741990
Mol Cell Neurosci. 2010 Jan;43(1):43-50
pubmed: 19837168
Neuropharmacology. 2005;49 Suppl 1:13-25
pubmed: 16024054
Front Mol Neurosci. 2018 Feb 06;11:31
pubmed: 29467618
Mol Genet Genomic Med. 2019 Nov;7(11):e956
pubmed: 31520524
Front Psychiatry. 2022 Jan 04;12:762967
pubmed: 35058813
Brain Res. 2006 Nov 22;1121(1):238-45
pubmed: 17046729
J Neurophysiol. 2007 Oct;98(4):2244-54
pubmed: 17715197
Hum Genet. 2002 Jun;110(6):601-5
pubmed: 12107447
Neuron. 2005 Mar 3;45(5):753-64
pubmed: 15748850
Cereb Cortex. 2009 Jul;19(7):1515-20
pubmed: 18787232
J Neurosci. 2001 Jul 15;21(14):5139-46
pubmed: 11438589
Exp Neurol. 2017 Nov;297:168-178
pubmed: 28822839
Cell. 1991 May 31;65(5):905-14
pubmed: 1710175
Int J Mol Sci. 2021 Mar 11;22(6):
pubmed: 33799851
J Neurosci. 2010 Jul 21;30(29):9929-38
pubmed: 20660275
Front Behav Neurosci. 2019 Jun 25;13:141
pubmed: 31293404
Nature. 1991 Feb 14;349(6310):624-6
pubmed: 1672039