Free-choice high-fat diet consumption reduces lateral hypothalamic GABAergic activity, without disturbing neural response to sucrose drinking in mice.
GABA
free-choice high-fat diet
lateral hypothalamus
sucrose drinking
two-photon microscopy
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2023
2023
Historique:
received:
09
05
2023
accepted:
21
07
2023
medline:
21
8
2023
pubmed:
21
8
2023
entrez:
21
8
2023
Statut:
epublish
Résumé
Nutrition can influence the brain and affect its regulation of food intake, especially that of high-palatable foods. We hypothesize that fat and sugar have interacting effects on the brain, and the lateral hypothalamus (LH) is a prime candidate to be involved in this interaction. The LH is a heterogeneous area, crucial for regulating consummatory behaviors, and integrating homeostatic and hedonic needs. GABAergic LH neurons stimulate feeding when activated, and are responsive to consummatory behavior while encoding sucrose palatability. Previously, we have shown that glutamatergic LH neurons reduce their activity in response to sugar drinking and that this response is disturbed by a free-choice high-fat diet (fcHFD). Whether GABAergic LH neurons, and their response to sugar, is affected by a fcHFD is yet unknown. Using head-fixed two-photon microscopy, we analyzed activity changes in LH
Identifiants
pubmed: 37600007
doi: 10.3389/fnins.2023.1219569
pmc: PMC10434857
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1219569Informations de copyright
Copyright © 2023 Slomp, Koekkoek, Mutersbaugh, Linville, Luquet and la Fleur.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Annu Rev Psychol. 2020 Jan 4;71:139-164
pubmed: 31561741
Int J Obes (Lond). 2007 Aug;31(8):1286-94
pubmed: 17325683
Physiol Behav. 2018 Aug 1;192:127-133
pubmed: 29454843
Nat Neurosci. 2019 Apr;22(4):642-656
pubmed: 30858605
Science. 2019 Jan 25;363(6425):346-347
pubmed: 30679360
Physiol Behav. 1992 Feb;51(2):371-9
pubmed: 1313591
FASEB J. 2021 Sep;35(9):e21804
pubmed: 34383974
Neuropsychopharmacology. 2016 Apr;41(5):1357-65
pubmed: 26365954
J Neurosci. 2005 Mar 2;25(9):2429-33
pubmed: 15745970
Psychoneuroendocrinology. 2021 Apr;126:105143
pubmed: 33493754
J Neurosci Methods. 2017 Nov 1;291:83-94
pubmed: 28782629
Appetite. 2020 Oct 1;153:104739
pubmed: 32439602
Endocrinology. 2011 Nov;152(11):4046-52
pubmed: 21914773
Front Behav Neurosci. 2015 Jul 02;9:173
pubmed: 26190984
Behav Brain Res. 2016 Jun 1;306:1-7
pubmed: 26970578
Nutrients. 2021 Apr 06;13(4):
pubmed: 33917347
Physiol Behav. 1975 Apr;14(04):483-6
pubmed: 1135293
Appetite. 2022 Oct 1;177:106146
pubmed: 35753443
Front Neurosci. 2021 Jan 21;14:608047
pubmed: 33551725
Cell Metab. 2018 Jul 03;28(1):33-44.e3
pubmed: 29909968
Sci Rep. 2019 Feb 12;9(1):1873
pubmed: 30755658
Nat Commun. 2018 Mar 14;9(1):1086
pubmed: 29540712
Nutr Res Rev. 2022 Dec;35(2):236-251
pubmed: 34184629
Neuron. 2016 Jan 20;89(2):285-99
pubmed: 26774160
Cell. 2015 Jan 29;160(3):516-27
pubmed: 25635459
Front Syst Neurosci. 2015 Jun 15;9:90
pubmed: 26124708
Neuron. 2015 Nov 4;88(3):553-64
pubmed: 26593092
Cell Metab. 2020 Apr 7;31(4):773-790.e11
pubmed: 32142669
Neuroscience. 1981;6(8):1601-24
pubmed: 7266881
Science. 2019 Jun 28;364(6447):1271-1274
pubmed: 31249056
J Auton Nerv Syst. 1982 Nov;6(3):303-22
pubmed: 7169500
Int J Obes (Lond). 2010 Mar;34(3):537-46
pubmed: 20029382
Cell Rep. 2021 Aug 24;36(8):109615
pubmed: 34433027
Neurosci Biobehav Rev. 2008;32(1):20-39
pubmed: 17617461
Neuroscience. 2016 Apr 21;320:183-93
pubmed: 26855191
J Neuroendocrinol. 2019 May;31(5):e12718
pubmed: 30958590
Neuropsychopharmacology. 2016 May;41(6):1505-12
pubmed: 26442599
Cell Metab. 2023 Mar 7;35(3):456-471.e6
pubmed: 36827985
Mol Metab. 2020 Jun;36:100977
pubmed: 32277924