Admixture mapping of peripheral artery disease in a Dominican population reveals a putative risk locus on 2q35.
Dominicans
admixture mapping
biobanks
genetic epidemiology
peripheral artery disease
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2023
2023
Historique:
received:
07
03
2023
accepted:
10
07
2023
medline:
21
8
2023
pubmed:
21
8
2023
entrez:
21
8
2023
Statut:
epublish
Résumé
Peripheral artery disease (PAD) is a form of atherosclerotic cardiovascular disease, affecting ∼8 million Americans, and is known to have racial and ethnic disparities. PAD has been reported to have a significantly higher prevalence in African Americans (AAs) compared to non-Hispanic European Americans (EAs). Hispanic/Latinos (HLs) have been reported to have lower or similar rates of PAD compared to EAs, despite having a paradoxically high burden of PAD risk factors; however, recent work suggests prevalence may differ between sub-groups. Here, we examined a large cohort of diverse adults in the Bio
Identifiants
pubmed: 37600667
doi: 10.3389/fgene.2023.1181167
pii: 1181167
pmc: PMC10432698
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1181167Subventions
Organisme : NHGRI NIH HHS
ID : R01 HG011345
Pays : United States
Organisme : CSRD VA
ID : IK2 CX001780
Pays : United States
Organisme : BLRD VA
ID : IK2 BX005759
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG009080
Pays : United States
Organisme : BLRD VA
ID : I01 BX003362
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG010297
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
Copyright © 2023 Cullina, Wojcik, Shemirani, Klarin, Gorman, Sorokin, Gignoux, Belbin, Pyarajan, Asgari, Tsao, Damrauer, Abul-Husn and Kenny.
Déclaration de conflit d'intérêts
EK received personal fees from Illumina, 23andMe, Allelica, and Regeneron Pharmaceuticals, received research funding from Allelica, and serves as a scientific advisory board member for Encompass Bio, Foresite Labs, and Galateo Bio. NA-H is an employee and equity holder of 23andMe; serves as a scientific advisory board member for Allelica; received personal fees from Genentech, Allelica, and 23andMe; received research funding from Akcea; and was previously employed by Regeneron Pharmaceuticals. ES is an employee of Calico Life Sciences LLC. SA received consulting fees from Variant Bio and Biogen Inc. CG owns stock in 23andMe and serves as an advisory board member for Encompass Bio. DK serve as scientific advisor to Bitterroot Bio, Inc. SMD receives research support from RenalytixAI and Novo Nordisk, outside the scope of the current research. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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