The paradigm of IL-23-independent production of IL-17F and IL-17A and their role in chronic inflammatory diseases.

Humans Arthritis, Psoriatic Chronic Disease Hidradenitis Suppurativa Immunity, Innate Inflammation Interleukin-17 Interleukin-23 Lymphocytes Psoriasis
IL-17A IL-17F IL-23 MAIT cells Th17 cells psoriasis spondyloarthritis γδ T cells

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2023
Historique:
received: 22 03 2023
accepted: 05 07 2023
medline: 22 8 2023
pubmed: 21 8 2023
entrez: 21 8 2023
Statut: epublish

Résumé

Interleukin-17 family (IL-17s) comprises six structurally related members (IL-17A to IL-17F); sequence homology is highest between IL-17A and IL-17F, displaying certain overlapping functions. In general, IL-17A and IL-17F play important roles in chronic inflammation and autoimmunity, controlling bacterial and fungal infections, and signaling mainly through activation of the nuclear factor-kappa B (NF-κB) pathway. The role of IL-17A and IL-17F has been established in chronic immune-mediated inflammatory diseases (IMIDs), such as psoriasis (PsO), psoriatic arthritis (PsA), axial spondylarthritis (axSpA), hidradenitis suppurativa (HS), inflammatory bowel disease (IBD), multiple sclerosis (MS), and asthma. CD4

Identifiants

DOI: 10.3389/fimmu.2023.1191782 PMID: 37600764 PMC: PMC10437113
pubmed: 37600764
doi: 10.3389/fimmu.2023.1191782
pmc: PMC10437113
doi:

Substances chimiques

Interleukin-17 0
Interleukin-23 0
IL17A protein, human 0
IL17F protein, human 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1191782

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2023 Navarro-Compán, Puig, Vidal, Ramírez, Llamas-Velasco, Fernández-Carballido, Almodóvar, Pinto, Galíndez-Aguirregoikoa, Zarco, Joven, Gratacós, Juanola, Blanco, Arias-Santiago, Sanz Sanz, Queiro and Cañete.

Déclaration de conflit d'intérêts

Author VN-C has served as a speaker, consultant, and/or instructor for: AbbVie, Eli Lilly and Company, Galapagos, Janssen, Moonlake, Novartis, Pfizer, and UCB Pharma; and has received grant and/or research support from AbbVie and Novartis. Author LP has received consultancy and/or speaker’s honoraria from and/or participated in clinical trials and/or research projects sponsored by AbbVie, Almirall, Amgen, Biogen, Boehringer Ingelheim, Bristol Myers Squibb, Janssen, LEO Pharma, Lilly, Novartis, Pfizer, Sandoz, Sanofi, and UCB. Author SV has received speaker’s honoraria and participated in projects sponsored by Bayer, Janssen, LEO Pharma, Lilly, Novartis, Pfizer, Roche, Sanofi and UCB. Author JR has received consultancy and/or speaker’s honoraria from Abbvie, UCB, Janssen, Novartis, Pfizer, Amgen and Lilly and/or participated in clinical trials and/or research projects sponsored by Pfizer, Novartis and Janssen. Author ML-V has received consultancy and/or speaker’s honoraria from and/or participated in clinical trials and/or research projects sponsored by AbbVie, Almirall, Amgen, Boehringer Ingelheim, Celgene, Janssen, Kyowa Kirian, LEO Pharma, Lilly, Novartis, and UCB. Author CF-C has received consultancy and/or speaker’s honoraria and participated in clinical trials and/or research projects sponsored by AbbVie, Janssen, Lilly, MSD, Novartis, Pfizer, the Spanish Society of Rheumatology and UCB. Author RA has received consultancy and/or speaker’s honoraria from and/or participated in clinical trials and/or research projects sponsored by AbbVie, Almirall, Amgen, Galápagos, Gebro, Janssen, Lilly, MSD, Nordimet, Novartis, Pfizer and UCB. Author JP has received consultancy and/or speaker’s honoraria from and/or participated in clinical trials and/or research projects sponsored by Janssen, Novartis, Pfizer, MSD, Lilly, Amgen, BMS, AbbVie, and UCB. Author EG-A has received consultancy and/or speaker’s honoraria from and/or participated in clinical trials and/or research projects sponsored by AbbVie, MSD, Roche, Amgen, Janssen, Lilly, Novartis, Pfizer and UCB. Author PZ has received consultancy and/or speaker’s honoraria from and/or participated in clinical trials and/or research projects sponsored by AbbVie, Celgene, Galapagos, Janssen, Lilly, MSD, Novartis, Pfizer and UCB. Author BJ has received consultancy fees from Amgen, UCB and Janssen; has received speaker’s honoraria from Lilly, Abbvie and Janssen; has participated in clinical trials and/or research projects sponsored by Janssen, Lilly, Bristol Myers Squibb, Abbvie; has received support for attending congress from Novartis, Pfizer, UCB. Author JG has received consultancy and/or speaker’s honoraria from and/or participated in clinical trials and/or research projects sponsored by Novartis, UCB, Pfizer, BMS, MSD, AbbVie, Lilly, Janssen, AstraZeneca and Galápagos. Author XJ has received consultancy and/or speaker’s honoraria from and/or participated in clinical trials and/or research projects sponsored by AbbVie, Lilly, MSD, Nordic Pharma, Novartis, Pfizer and UCB. Author RB has received grants/research supports from Abbvie, MSD, and Roche, and had consultation fees/participation in company-sponsored speaker´s bureau from Abbvie, Pfizer, Roche, Bristol-Myers, Lilly, Janssen, and MSD. Author SA has received consultancy and/or speaker’s honoraria from and/or participated in clinical trials and/or research projects sponsored by AbbVie, Almirall, Janssen, LEO Pharma, Lilly, Novartis and UCB. Author JS has received consultancy and/or speaker’s honoraria from and/or participated in clinical trials and/or research projects sponsored by AbbVie, UCB, Novartis, Amgen, Pfizer and Janssen-Cilag. Author RQ has received consultancy and/or speaker’s honoraria from and/or participated in clinical trials and/or research projects sponsored by Novartis, Janssen, UCB, Pfizer, Amgen, MSD, Eli-Lilly and AbbVie. Author JC has received consultancy and/or speaker’s honoraria from and/or participated in clinical trials and/or research projects sponsored by AbbVie, Almirall, Biogen, Boehringer Ingelheim, Bristol Myers Squibb, Fresenius, Janssen, Lilly, Novartis, Pfizer, Sandoz and UCB.

Références

Adv Exp Med Biol. 2019;1172:97-117
pubmed: 31628653
Arthritis Rheumatol. 2022 Nov;74(11):1786-1795
pubmed: 35166073
Immunity. 2009 Aug 21;31(2):321-30
pubmed: 19682928
J Allergy Clin Immunol. 2017 Mar;139(3):923-932.e8
pubmed: 27502297
Eur J Immunol. 2015 Nov;45(11):3045-51
pubmed: 26300525
Exp Dermatol. 2014 Nov;23(11):799-803
pubmed: 25039885
Immunity. 2015 Sep 15;43(3):566-78
pubmed: 26362265
J Immunol. 2008 Aug 15;181(4):2799-805
pubmed: 18684971
Biomed Res. 2017;38(2):111-121
pubmed: 28442662
Nat Immunol. 2012 Oct;13(10):991-9
pubmed: 22961052
Nat Med. 2007 Jun;13(6):711-8
pubmed: 17496900
Nat Rev Gastroenterol Hepatol. 2019 Mar;16(3):185-196
pubmed: 30478416
Ann Rheum Dis. 2019 Nov;78(11):1559-1565
pubmed: 31530557
Clin Exp Immunol. 2004 Aug;137(2):437-43
pubmed: 15270864
J Immunol. 2018 Feb 15;200(4):1249-1254
pubmed: 29330320
Sci Signal. 2009 Feb 24;2(59):ra8
pubmed: 19244213
Arthritis Rheum. 2012 Apr;64(4):1134-44
pubmed: 22006066
Am J Respir Crit Care Med. 2013 Dec 1;188(11):1294-302
pubmed: 24200404
Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4):
pubmed: 28620097
Arthritis Rheumatol. 2021 Jul;73(7):1220-1232
pubmed: 33452865
Nat Rev Immunol. 2014 Sep;14(9):585-600
pubmed: 25145755
Immunity. 2011 Oct 28;35(4):596-610
pubmed: 21982596
EMBO J. 2001 Oct 1;20(19):5332-41
pubmed: 11574464
Front Immunol. 2021 Feb 01;11:613204
pubmed: 33597948
Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11287-92
pubmed: 18685112
Nat Commun. 2015 May 21;6:7146
pubmed: 25994336
Nat Rev Immunol. 2013 Feb;13(2):145-9
pubmed: 23348417
J Immunol. 2008 Oct 1;181(7):4791-7
pubmed: 18802082
Nat Immunol. 2005 Nov;6(11):1133-41
pubmed: 16200068
Nat Immunol. 2007 Sep;8(9):950-7
pubmed: 17676044
Clin Immunol. 2014 May-Jun;152(1-2):36-47
pubmed: 24681356
Front Immunol. 2020 Nov 17;11:594735
pubmed: 33281823
Nat Immunol. 2017 May 18;18(6):604-611
pubmed: 28518154
Trends Biochem Sci. 2003 May;28(5):226-9
pubmed: 12765832
Front Immunol. 2021 Feb 22;12:637829
pubmed: 33692806
Arthritis Rheumatol. 2017 Sep;69(9):1816-1822
pubmed: 28511289
Front Cell Dev Biol. 2022 Feb 03;9:799560
pubmed: 35186952
Clin Immunol. 2017 Oct;183:207-212
pubmed: 28390966
Ann Rheum Dis. 2016 Dec;75(12):2124-2132
pubmed: 27165176
Immunity. 2009 Aug 21;31(2):331-41
pubmed: 19682929
Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17549-54
pubmed: 23047700
J Invest Dermatol. 2014 Apr;134(4):984-991
pubmed: 24352038
Nat Immunol. 2016 Jun 21;17(7):765-74
pubmed: 27328006
Nat Rev Immunol. 2012 Mar 22;12(4):239-52
pubmed: 22437937
J Am Acad Dermatol. 2011 Oct;65(4):790-798
pubmed: 21641076
Sci Rep. 2017 Oct 16;7(1):12895
pubmed: 29038541
J Immunol. 2010 Apr 15;184(8):4307-16
pubmed: 20231694
Immunity. 2015 Oct 20;43(4):727-38
pubmed: 26431948
Cytokine. 2021 Dec;148:155715
pubmed: 34587561
Cell Rep. 2017 Aug 15;20(7):1667-1680
pubmed: 28813677
Expert Rev Clin Immunol. 2015;11(8):885-95
pubmed: 26004582
Nature. 2008 Jul 17;454(7202):350-2
pubmed: 18469800
N Engl J Med. 2015 Dec 24;373(26):2534-48
pubmed: 26699169
Lancet. 2015 Sep 5;386(9997):983-94
pubmed: 26025581
FEBS Lett. 2014 Nov 17;588(22):4176-81
pubmed: 24681095
Nat Rev Immunol. 2010 Jul;10(7):479-89
pubmed: 20559326
Arthritis Rheumatol. 2014 May;66(5):1272-81
pubmed: 24470327
Protein Cell. 2011 Jan;2(1):26-40
pubmed: 21337007
Autoimmun Rev. 2020 Jan;19(1):102429
pubmed: 31734402
Nat Immunol. 2007 Dec;8(12):1390-7
pubmed: 17994024
Front Immunol. 2021 Feb 25;12:622306
pubmed: 33717125
Nat Rev Drug Discov. 2012 Oct;11(10):763-76
pubmed: 23023676
Nat Immunol. 2017 May 18;18(6):612-621
pubmed: 28518156
Cytokine. 2020 Jan;125:154855
pubmed: 31541902
Int J Mol Sci. 2018 Feb 01;19(2):
pubmed: 29389901
Arthritis Rheumatol. 2020 Mar;72(3):435-447
pubmed: 31677365
Annu Rev Immunol. 2007;25:821-52
pubmed: 17201677
Curr Opin Rheumatol. 2021 Jul 1;33(4):333-340
pubmed: 34001692
Arthritis Res Ther. 2013 Sep 26;15(5):R136
pubmed: 24286492
Blood. 2010 Dec 2;116(23):4829-37
pubmed: 20713963
Nat Rev Immunol. 2009 Aug;9(8):556-67
pubmed: 19575028
Clin Dev Immunol. 2012;2012:925135
pubmed: 22474485
J Immunol. 2007 Oct 15;179(8):5462-73
pubmed: 17911633
Front Immunol. 2020 Nov 20;11:585134
pubmed: 33329560
Front Immunol. 2018 Jul 13;9:1610
pubmed: 30057583
Lancet Gastroenterol Hepatol. 2018 Oct;3(10):671-680
pubmed: 30056030
J Invest Dermatol. 2013 Jan;133(1):17-26
pubmed: 22673731
Curr Rheumatol Rep. 2015 May;17(5):30
pubmed: 25874346
Curr Top Microbiol Immunol. 2007;314:269-91
pubmed: 17593665
Immunity. 2008 Jan;28(1):29-39
pubmed: 18164222
Eur J Immunol. 2009 Dec;39(12):3488-97
pubmed: 19830744
Ann Rheum Dis. 2015 Sep;74(9):1739-47
pubmed: 25902790
Immunity. 2020 Aug 18;53(2):384-397.e5
pubmed: 32673565
Dig Dis Sci. 2007 Jun;52(6):1415-22
pubmed: 17420939
Eur J Hum Genet. 2002 Sep;10(9):562-8
pubmed: 12173034
J Allergy Clin Immunol. 2022 Oct;150(4):882-893
pubmed: 35568077
Mucosal Immunol. 2014 Sep;7(5):1058-67
pubmed: 24448098
Immunity. 2020 Mar 17;52(3):499-512.e5
pubmed: 32187518
Nat Immunol. 2018 Jul;19(7):648-650
pubmed: 29915294
Am J Gastroenterol. 2016 Nov;111(11):1599-1607
pubmed: 27481309
Immunity. 2015 Oct 20;43(4):739-50
pubmed: 26431947
Nat Commun. 2022 Jun 27;13(1):3688
pubmed: 35760777
Nat Commun. 2019 Jan 2;10(1):9
pubmed: 30602780
Nat Rev Immunol. 2019 Oct;19(10):643-657
pubmed: 31308521
Eur J Clin Invest. 2021 Aug;51(8):e13572
pubmed: 33851422
Inflamm Res. 2020 Oct;69(10):967-973
pubmed: 32661800
J Exp Med. 2008 May 12;205(5):1063-75
pubmed: 18411338
J Invest Dermatol. 2014 Dec;134(12):2898-2907
pubmed: 24945094
Immunity. 2011 Feb 25;34(2):149-62
pubmed: 21349428
Eur J Immunol. 2009 Jan;39(1):207-15
pubmed: 19130583
Nat Commun. 2018 Jul 6;9(1):2627
pubmed: 29980684
Semin Immunopathol. 2021 Apr;43(2):265-277
pubmed: 33569634
Lancet. 2018 Dec 8;392(10163):2441-2451
pubmed: 30360964
Nat Rev Immunol. 2004 Mar;4(3):231-7
pubmed: 15039760
Autoimmun Rev. 2021 Mar;20(3):102760
pubmed: 33485992
J Exp Med. 2006 Oct 2;203(10):2271-9
pubmed: 16982811
Int J Mol Sci. 2015 Dec 29;17(1):
pubmed: 26729099
Immunol Lett. 2016 Oct;178:20-6
pubmed: 27173097
Ophthalmology. 2013 Apr;120(4):777-87
pubmed: 23290985
Arthritis Rheumatol. 2019 Feb;71(2):258-270
pubmed: 30225992
J Gastroenterol Hepatol. 2016 May;31(5):965-72
pubmed: 26590105
J Eur Acad Dermatol Venereol. 2017 Sep;31(9):1491-1496
pubmed: 28585707
J Immunol. 2009 Aug 1;183(3):2142-9
pubmed: 19587013
Eur J Immunol. 2020 Apr;50(4):568-580
pubmed: 31850514
J Autoimmun. 2018 Feb;87:69-81
pubmed: 29254845
Mucosal Immunol. 2020 Jan;13(1):128-139
pubmed: 31628425
Ther Adv Chronic Dis. 2021 Aug 12;12:20406223211037846
pubmed: 34408825
Immunology. 2016 May;148(1):1-12
pubmed: 26778581
J Immunol. 2006 Jul 1;177(1):36-9
pubmed: 16785495
Nat Commun. 2015 Feb 05;6:6046
pubmed: 25651891
Ann Rheum Dis. 2018 Sep;77(9):1295-1302
pubmed: 29945918
Front Immunol. 2018 Jun 26;9:1450
pubmed: 29997620
Front Immunol. 2019 Jun 27;10:1293
pubmed: 31316496
Curr Rheumatol Rep. 2021 Apr 24;23(5):31
pubmed: 33893896
Nat Immunol. 2018 Jul;19(7):755-765
pubmed: 29915298
Annu Rev Med. 2016;67:337-53
pubmed: 26565676
Br J Dermatol. 2014 Mar;170(3):609-16
pubmed: 24125475
Clin Exp Immunol. 2016 Dec;186(3):277-283
pubmed: 27543964
J Biomed Biotechnol. 2011;2011:248317
pubmed: 21687543
Front Immunol. 2018 Jul 09;9:1550
pubmed: 30038617
Ocul Immunol Inflamm. 2021 Apr 3;29(3):558-565
pubmed: 31763950
Cell Rep. 2019 Sep 17;28(12):3077-3091.e5
pubmed: 31533032
Br J Dermatol. 2022 Apr;186(4):652-663
pubmed: 34687214
Arthritis Rheumatol. 2015 Oct;67(10):2673-8
pubmed: 26137857
Immunity. 2019 Apr 16;50(4):892-906
pubmed: 30995505
Arthritis Res Ther. 2015 Jul 09;17:173
pubmed: 26156866
Nat Immunol. 2019 Sep;20(9):1110-1128
pubmed: 31406380
Expert Opin Drug Discov. 2018 Jun;13(6):551-562
pubmed: 29663834
Gut. 2012 Dec;61(12):1693-700
pubmed: 22595313
J Rheumatol. 2020 Nov 1;47(11):1606-1613
pubmed: 31941804
J Exp Med. 2007 May 14;204(5):995-1001
pubmed: 17470641
Front Immunol. 2021 Jan 08;11:553742
pubmed: 33488572
Dermatol Ther (Heidelb). 2023 May;13(5):1099-1111
pubmed: 36892753
Mucosal Immunol. 2021 Jul;14(4):803-814
pubmed: 33753874
Trends Immunol. 2012 Jul;33(7):343-9
pubmed: 22476048
Front Immunol. 2017 Jun 30;8:761
pubmed: 28713381
Br J Dermatol. 2023 Apr 20;188(5):601-609
pubmed: 36811949
Cell Mol Immunol. 2019 Jun;16(6):531-539
pubmed: 30874627
Ann Rheum Dis. 2018 Apr;77(4):523-532
pubmed: 29275332
Front Immunol. 2018 Aug 02;9:1682
pubmed: 30127781
RMD Open. 2020 Jul;6(2):
pubmed: 32723833
J Immunol. 2008 Apr 15;180(8):5167-71
pubmed: 18390697
Nat Rev Microbiol. 2007 Jun;5(6):405-17
pubmed: 17487145
Nature. 2010 Oct 21;467(7318):967-71
pubmed: 20962846
Eur J Immunol. 2020 Aug;50(8):1098-1108
pubmed: 32617963
Lancet. 2023 Mar 4;401(10378):747-761
pubmed: 36746171
Clin Rev Allergy Immunol. 2018 Dec;55(3):379-390
pubmed: 30109481
Blood. 2011 Jan 27;117(4):1250-9
pubmed: 21084709
Sci Rep. 2019 Jul 26;9(1):10870
pubmed: 31350460
Cell. 2006 Sep 22;126(6):1121-33
pubmed: 16990136
J Immunol. 2011 May 15;186(10):5738-48
pubmed: 21471445

Auteurs

Victoria Navarro-Compán (V)

Department of Rheumatology, Hospital Universitario La Paz, IdiPaz, Madrid, Spain.

Luis Puig (L)

Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Silvia Vidal (S)

Immunology-Inflammatory Diseases, Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.

Julio Ramírez (J)

Arthritis Unit, Department of Rheumatology, Hospital Clínic and Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Mar Llamas-Velasco (M)

Department of Dermatology, Hospital Universitario La Princesa, Madrid, Spain.

Cristina Fernández-Carballido (C)

Department of Rheumatology, Hospital Universitario San Juan de Alicante, Alicante, Spain.

Raquel Almodóvar (R)

Department of Rheumatology, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain.

José Antonio Pinto (JA)

Department of Rheumatology, Complejo Hospitalario Universitario de A Coruña, Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Spain.

Eva Galíndez-Aguirregoikoa (E)

Department of Rheumatology, Hospital Universitario de Basurto, Bilbao, Spain.

Pedro Zarco (P)

Department of Rheumatology, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain.

Beatriz Joven (B)

Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain.

Jordi Gratacós (J)

Department of Rheumatology, Medicine Department Autonomus University of Barcelona (UAB), I3PT, University Hospital Parc Taulí Sabadell, Barcelona, Spain.

Xavier Juanola (X)

Department of Rheumatology, University Hospital Bellvitge, Instituto de Investigación Biomédica de Bellvitge (IDIBELL), Barcelona, Spain.

Ricardo Blanco (R)

Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander, Spain.

Salvador Arias-Santiago (S)

Department of Dermatology, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.
Department of Dermatology, Facultad de Medicina, Universidad de Granada, Spain.

Jesús Sanz Sanz (J)

Department of Rheumatology, Hospital Universitario Puerta del Hierro Majadahonda, Madrid, Spain.

Rubén Queiro (R)

Department of Rheumatology, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.

Juan D Cañete (JD)

Arthritis Unit, Department of Rheumatology, Hospital Clínic and Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The paradigm of IL-23-independent production...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses papulosquameuses › Psoriasis › Arthrite psoriasique › The paradigm of IL-23-independent production...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › The paradigm of IL-23-independent production...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies des glandes sudoripares › Hidrosadénite › Hidrosadénite suppurée › The paradigm of IL-23-independent production...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › The paradigm of IL-23-independent production...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › The paradigm of IL-23-independent production...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-17 › The paradigm of IL-23-independent production...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-23 › The paradigm of IL-23-independent production...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › The paradigm of IL-23-independent production...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses papulosquameuses › Psoriasis › The paradigm of IL-23-independent production...