Association between serum trace elements and sleep disturbance in patients with decompensated cirrhosis.
Cu/Zn ratio
PSQI
liver cirrhosis
sleep disturbance
trace element
Journal
Therapeutic advances in chronic disease
ISSN: 2040-6223
Titre abrégé: Ther Adv Chronic Dis
Pays: United States
ID NLM: 101532140
Informations de publication
Date de publication:
2023
2023
Historique:
received:
03
02
2023
accepted:
17
07
2023
medline:
21
8
2023
pubmed:
21
8
2023
entrez:
21
8
2023
Statut:
epublish
Résumé
Sleep disturbance and trace elements imbalance are common features in patients with decompensated cirrhosis, partially sharing similar mechanistic contributors and linking to adverse outcomes. However, there is a paucity of data concerning their relationship. To investigate the association between serum trace elements levels and sleep quality in the context of cirrhosis. Cross-sectional study. We consecutively enrolled 160 patients with decompensated cirrhosis. The sleep disturbance was determined by the Pittsburgh Sleep Quality Index (PSQI > 5). Serum trace elements [magnesium, calcium, iron, copper (Cu), zinc (Zn), lead, and manganese] was measured by inductively coupled plasma mass spectrometry. Association of examined trace elements levels and sleep disturbance was analyzed by multiple linear (global PSQI scores) and multivariate logistic (dichotomized PSQI categories) regression models, respectively. In total, 91 patients (56.88%) represented PSQI-defined sleep disturbance, characterized by female preponderance, lower body mass index levels, and higher serum Cu levels (all Our findings implied an association between higher CZr and the presence of sleep disturbance in patients with decompensated cirrhosis.
Sections du résumé
Background
UNASSIGNED
Sleep disturbance and trace elements imbalance are common features in patients with decompensated cirrhosis, partially sharing similar mechanistic contributors and linking to adverse outcomes. However, there is a paucity of data concerning their relationship.
Objectives
UNASSIGNED
To investigate the association between serum trace elements levels and sleep quality in the context of cirrhosis.
Design
UNASSIGNED
Cross-sectional study.
Methods
UNASSIGNED
We consecutively enrolled 160 patients with decompensated cirrhosis. The sleep disturbance was determined by the Pittsburgh Sleep Quality Index (PSQI > 5). Serum trace elements [magnesium, calcium, iron, copper (Cu), zinc (Zn), lead, and manganese] was measured by inductively coupled plasma mass spectrometry. Association of examined trace elements levels and sleep disturbance was analyzed by multiple linear (global PSQI scores) and multivariate logistic (dichotomized PSQI categories) regression models, respectively.
Results
UNASSIGNED
In total, 91 patients (56.88%) represented PSQI-defined sleep disturbance, characterized by female preponderance, lower body mass index levels, and higher serum Cu levels (all
Conclusion
UNASSIGNED
Our findings implied an association between higher CZr and the presence of sleep disturbance in patients with decompensated cirrhosis.
Identifiants
pubmed: 37601039
doi: 10.1177/20406223231192829
pii: 10.1177_20406223231192829
pmc: PMC10439724
doi:
Types de publication
Journal Article
Langues
eng
Pagination
20406223231192829Informations de copyright
© The Author(s), 2023.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest.
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