Alleviation of hippocampal necroptosis and neuroinflammation by NecroX-7 treatment after acute seizures.
NecroX-7
excitotoxicity
hippocampus
necroptosis
neuroinflammation
neuroprotection
seizure
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2023
2023
Historique:
received:
16
03
2023
accepted:
24
07
2023
medline:
21
8
2023
pubmed:
21
8
2023
entrez:
21
8
2023
Statut:
epublish
Résumé
Temporal lobe epilepsy (TLE) is one of the most common neurological disorders, but still one-third of patients cannot be properly treated by current medication. Thus, we investigated the therapeutic effects of a novel small molecule, NecroX-7, in TLE using both a low [Mg
Identifiants
pubmed: 37601059
doi: 10.3389/fphar.2023.1187819
pii: 1187819
pmc: PMC10433749
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1187819Informations de copyright
Copyright © 2023 Roh, Lee, Kim, Kim, Kim and Cho.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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