Regulation of insulin secretion by the post-translational modifications.
O-GlcNAcylation
PTMs
acetylation
insulin secretion
palmitoylation
phosphorylation
sumoylation
ubiquitination
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2023
2023
Historique:
received:
05
05
2023
accepted:
24
07
2023
medline:
21
8
2023
pubmed:
21
8
2023
entrez:
21
8
2023
Statut:
epublish
Résumé
Post-translational modification (PTM) has a significant impact on cellular signaling and function regulation. In pancreatic β cells, PTMs are involved in insulin secretion, cell development, and viability. The dysregulation of PTM in β cells is clinically associated with the development of diabetes mellitus. Here, we summarized current findings on major PTMs occurring in β cells and their roles in insulin secretion. Our work provides comprehensive insight into understanding the mechanisms of insulin secretion and potential therapeutic targets for diabetes from the perspective of protein PTMs.
Identifiants
pubmed: 37601108
doi: 10.3389/fcell.2023.1217189
pii: 1217189
pmc: PMC10436566
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1217189Informations de copyright
Copyright © 2023 Yang, Wei, Zhao, Yang, Song, Mi, Yang and Tian.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Signal Transduct Target Ther. 2023 May 27;8(1):220
pubmed: 37244925
Diabetes. 2006 Mar;55(3):574-81
pubmed: 16505218
Curr Issues Mol Biol. 2016;18:49-56
pubmed: 26234807
J Biol Chem. 2008 Apr 11;283(15):9909-16
pubmed: 18174159
J Biol Chem. 2016 Dec 9;291(50):25888-25900
pubmed: 27777306
Mol Endocrinol. 2012 Jul;26(7):1225-34
pubmed: 22669743
Mol Ther Nucleic Acids. 2021 Jul 16;26:307-320
pubmed: 34513312
Nat Cell Biol. 2004 Mar;6(3):207-14
pubmed: 15039777
Nat Med. 2005 Oct;11(10):1104-8
pubmed: 16155576
J Clin Invest. 1996 Oct 15;98(8):1703-8
pubmed: 8878419
Cell Signal. 2008 Oct;20(10):1787-94
pubmed: 18625302
J Biol Chem. 2016 May 6;291(19):10162-72
pubmed: 26984405
Cell Metab. 2017 Apr 4;25(4):838-855.e15
pubmed: 28380376
Nat Rev Mol Cell Biol. 2010 Dec;11(12):861-71
pubmed: 21102611
Diabetologia. 2009 Jun;52(6):1112-21
pubmed: 19357830
Biochem J. 2021 Apr 30;478(8):1605-1615
pubmed: 33605402
Cell Death Dis. 2019 Jan 25;10(2):66
pubmed: 30683850
Mol Endocrinol. 2001 Aug;15(8):1423-35
pubmed: 11463864
J Cell Sci. 2000 Sep;113 ( Pt 18):3197-205
pubmed: 10954418
Diabetologia. 2007 Aug;50(8):1649-59
pubmed: 17593347
Diabetes. 2011 May;60(5):1535-43
pubmed: 21444924
Pharmacol Ther. 2017 Nov;179:17-30
pubmed: 28527919
J Cell Physiol. 2015 Jul;230(7):1448-56
pubmed: 25641109
J Biol Chem. 1994 Oct 28;269(43):27036-44
pubmed: 7929445
Am J Physiol Cell Physiol. 2014 Nov 1;307(9):C774-87
pubmed: 25143351
J Cell Sci. 2009 Mar 15;122(Pt 6):775-9
pubmed: 19223394
Antioxid Redox Signal. 2017 May 20;26(15):849-863
pubmed: 27460777
Trends Biochem Sci. 2011 Feb;36(2):108-16
pubmed: 20934340
Exp Mol Pathol. 2020 Jun;114:104432
pubmed: 32243891
Trends Endocrinol Metab. 2015 Dec;26(12):676-687
pubmed: 26498855
Annu Rev Physiol. 1999;61:337-62
pubmed: 10099692
Nature. 2013 Feb 21;494(7437):375-9
pubmed: 23354051
Biochem Biophys Res Commun. 1993 Feb 26;191(1):255-61
pubmed: 8383489
J Mol Med (Berl). 2005 Jul;83(7):504-13
pubmed: 15806321
Arch Biochem Biophys. 2003 Jul 15;415(2):155-63
pubmed: 12831837
Biochem Biophys Res Commun. 2017 Sep 23;491(3):740-746
pubmed: 28739256
J Biol Chem. 2012 Mar 23;287(13):9862-9872
pubmed: 22298778
Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28307-28315
pubmed: 33122440
Diabetes. 2020 Sep;69(9):1936-1947
pubmed: 32540877
EMBO J. 2004 Feb 25;23(4):833-43
pubmed: 14976552
Diabetologia. 2018 Apr;61(4):881-895
pubmed: 29299635
Diabetes. 2020 May;69(5):940-953
pubmed: 32086291
PLoS Genet. 2011 Oct;7(10):e1002323
pubmed: 21998599
Cell. 2004 May 14;117(4):421-6
pubmed: 15137936
J Biol Chem. 2006 May 12;281(19):13015-13020
pubmed: 16543239
Diabetes. 2011 Jan;60(1):320-30
pubmed: 20870970
Curr Opin Genet Dev. 2022 Oct;76:101956
pubmed: 35843204
Nat Rev Mol Cell Biol. 2011 Mar;12(3):141-51
pubmed: 21346730
Biochim Biophys Acta. 1999 Jul 30;1439(2):229-44
pubmed: 10425398
Development. 1998 Jun;125(12):2213-21
pubmed: 9584121
Arch Biochem Biophys. 1999 Feb 1;362(1):38-45
pubmed: 9917327
Cell Metab. 2008 Jul;8(1):26-37
pubmed: 18590690
Annu Rev Biochem. 2012;81:203-29
pubmed: 22524316
FEBS Lett. 1982 Mar 8;139(1):4-8
pubmed: 6281063
Chem Phys Lipids. 2014 May;180:44-52
pubmed: 24534427
Nat Cell Biol. 2014 Mar;16(3):234-44
pubmed: 24561619
Diabetes. 2011 Mar;60(3):838-47
pubmed: 21266332
J Clin Med. 2018 Mar 12;7(3):
pubmed: 29534517
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2376-81
pubmed: 22308370
Nat Biotechnol. 2006 Oct;24(10):1241-52
pubmed: 17033665
Diabetes. 2015 Mar;64(3):904-15
pubmed: 25281428
Annu Rev Biochem. 2013;82:357-85
pubmed: 23746258
PLoS One. 2015 Jun 05;10(6):e0129238
pubmed: 26046640
Nat Med. 2008 Oct;14(10):1112-7
pubmed: 18758446
Physiol Rev. 2015 Apr;95(2):341-76
pubmed: 25834228
Diabetes. 2006 Dec;55 Suppl 2:S16-23
pubmed: 17130640
J Diabetes Res. 2016;2016:1964634
pubmed: 26824039
Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2334-9
pubmed: 16461897
Am J Physiol Endocrinol Metab. 2012 Mar 15;302(6):E714-23
pubmed: 22234371
Am J Physiol Endocrinol Metab. 2003 Apr;284(4):E830-40
pubmed: 12488243
Cell Metab. 2006 Feb;3(2):123-34
pubmed: 16459313
Angew Chem Int Ed Engl. 2005 Dec 1;44(45):7342-72
pubmed: 16267872
Int J Mol Sci. 2015 Mar 18;16(3):6281-97
pubmed: 25794287
Front Immunol. 2021 Jun 01;12:678953
pubmed: 34140951
Genes Dev. 2006 May 15;20(10):1256-61
pubmed: 16648462
Can J Physiol Pharmacol. 2006 Jul;84(7):713-24
pubmed: 16998535
Cell Metab. 2005 Aug;2(2):105-17
pubmed: 16098828
Cell Metab. 2023 Feb 7;35(2):332-344.e7
pubmed: 36634673
Endocrinology. 2018 Aug 1;159(8):3036-3047
pubmed: 29873699
Biochem J. 2008 Oct 1;415(1):1-10
pubmed: 18778246
Cell Mol Life Sci. 2021 Mar;78(5):1957-1970
pubmed: 33146746
J Biol Chem. 2014 Sep 5;289(36):25276-86
pubmed: 25002582
Nat Commun. 2022 Apr 6;13(1):1870
pubmed: 35388005
Mol Endocrinol. 2003 Apr;17(4):732-42
pubmed: 12554769
Physiol Rev. 2015 Oct;95(4):1383-436
pubmed: 26400989
Mol Biol Cell. 2005 Jun;16(6):2670-80
pubmed: 15788565
Diabetes. 1999 Dec;48(12):2383-9
pubmed: 10580427
J Biol Chem. 2011 Jul 22;286(29):26118-26
pubmed: 21622566
Cell. 2012 Jul 6;150(1):207-21
pubmed: 22770221
Front Endocrinol (Lausanne). 2022 Jul 26;13:908248
pubmed: 35966081
PLoS One. 2013;8(3):e58655
pubmed: 23516528
Biomolecules. 2012 May 24;2(2):269-81
pubmed: 24970137
Bioorg Med Chem Lett. 2018 Mar 1;28(5):969-973
pubmed: 29439901
Biochem Biophys Res Commun. 2003 Nov 14;311(2):272-82
pubmed: 14592410
Biochim Biophys Acta. 2010 May-Jun;1799(5-6):353-64
pubmed: 20202486
Annu Rev Biochem. 1992;61:721-59
pubmed: 1497323
Mol Biosyst. 2007 Nov;3(11):766-72
pubmed: 17940659
J Biol Chem. 2012 Jul 27;287(31):26435-44
pubmed: 22669945
Biochem Biophys Res Commun. 2022 May 21;605:90-96
pubmed: 35316768
FASEB J. 2008 Jan;22(1):194-206
pubmed: 17709608
FASEB J. 2004 May;18(7):878-80
pubmed: 15033925
Curr Drug Targets. 2014;15(12):1094-106
pubmed: 25230117
Biochemistry. 2017 Jul 25;56(29):3808-3817
pubmed: 28665109
Diabetes Spectr. 2014 May;27(2):100-12
pubmed: 26246766
J Immunol. 2017 May 15;198(10):3927-3938
pubmed: 28424240
Nat Rev Mol Cell Biol. 2017 Jul;18(7):452-465
pubmed: 28488703
Mol Metab. 2014 Aug 23;3(8):803-12
pubmed: 25379405
Nature. 2013 Nov 7;503(7474):59-66
pubmed: 24201279
Biochem Biophys Res Commun. 2010 Jun 25;397(2):140-5
pubmed: 20471962
Biophys J. 2020 Jan 7;118(1):193-206
pubmed: 31839261
Nat Med. 2014 Apr;20(4):385-397
pubmed: 24633305
Diabetes. 2009 Dec;58(12):2813-9
pubmed: 19720793
PLoS One. 2014 Feb 04;9(2):e87812
pubmed: 24504462
Diabetologia. 2016 Jan;59(1):151-160
pubmed: 26471901
Diabetes Obes Metab. 2016 Aug;18(8):747-54
pubmed: 27097743
Diabetes. 2009 May;58(5):1105-15
pubmed: 19223597
Diabetes Res Clin Pract. 2011 Aug;93 Suppl 1:S27-31
pubmed: 21864748
Commun Biol. 2020 Sep 8;3(1):497
pubmed: 32901087
J Cell Sci. 2012 Nov 1;125(Pt 21):5084-95
pubmed: 22946044
J Biol Chem. 2013 Feb 22;288(8):5951-62
pubmed: 23297408
J Neurosci. 2020 Sep 23;40(39):7405-7420
pubmed: 32847966
Biosci Biotechnol Biochem. 2019 Sep;83(9):1676-1682
pubmed: 31094294
Mol Aspects Med. 2021 Jun;79:100885
pubmed: 32736806
J Biol Chem. 2000 Nov 17;275(46):36079-85
pubmed: 10938083
Sci Rep. 2017 Mar 21;7(1):248
pubmed: 28325894
FASEB J. 2018 Jun;32(6):3166-3173
pubmed: 29401605
Crit Rev Biochem Mol Biol. 2016 May-Jun;51(3):150-61
pubmed: 26806492
Expert Rev Proteomics. 2021 Nov;18(11):949-975
pubmed: 34791964
J Biol Chem. 2009 Jan 30;284(5):3117-3124
pubmed: 19029092
Mol Cell Biol. 2013 Jul;33(13):2527-34
pubmed: 23629625
Nat Commun. 2016 Nov 14;7:13250
pubmed: 27841257
J Biol Chem. 2016 Jan 29;291(5):2107-18
pubmed: 26598517
Genes Dev. 2003 Jul 1;17(13):1575-80
pubmed: 12842910
Sci Rep. 2019 Feb 27;9(1):2895
pubmed: 30814610
Nature. 2008 Feb 21;451(7181):964-9
pubmed: 18288188
Exp Mol Med. 2016 Mar 11;48:e219
pubmed: 26964835
Nat Rev Mol Cell Biol. 2021 Feb;22(2):142-158
pubmed: 33398164
Cold Spring Harb Perspect Biol. 2018 May 1;10(5):
pubmed: 29716949
J Biol Chem. 2007 May 25;282(21):15589-96
pubmed: 17403669
J Biol Chem. 2003 Jun 20;278(25):23055-65
pubmed: 12679364
J Biol Chem. 2002 Nov 22;277(47):44938-45
pubmed: 12270920
Diabetes. 2015 Oct;64(10):3339-41
pubmed: 26405271
DNA Cell Biol. 2012 Jan;31(1):8-14
pubmed: 21774670
Open Biol. 2021 Mar;11(3):210017
pubmed: 33784857
Mol Cell Biol. 2005 Jun;25(12):4969-76
pubmed: 15923615
Diabetologia. 2013 Sep;56(9):2010-20
pubmed: 23783352
Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9996-10001
pubmed: 26216970
Cell. 2006 Sep 8;126(5):941-54
pubmed: 16959573
Cell Metab. 2018 Oct 2;28(4):588-604.e5
pubmed: 30017357
Diabetes. 2006 May;55(5):1223-31
pubmed: 16644676
J Biol Chem. 2015 Dec 18;290(51):30530-9
pubmed: 26494622
Nat Commun. 2022 Dec 6;13(1):7522
pubmed: 36473871
Mol Cell Endocrinol. 2016 Mar 15;424:23-33
pubmed: 26797246
Cells. 2020 Jan 05;9(1):
pubmed: 31948094
Cell Rep. 2020 May 5;31(5):107609
pubmed: 32375037
PLoS Biol. 2019 Aug 20;17(8):e3000097
pubmed: 31430273
Am J Physiol. 1997 Oct;273(4):E782-9
pubmed: 9357809
Mol Cell Biol. 2013 Aug;33(15):2996-3010
pubmed: 23716596
Bioessays. 2018 May;40(5):e1700223
pubmed: 29611634