Prediabetes in rural adolescent girls from DERVAN cohort: data from the KONKAN region of the state of Maharashtra, India (DERVAN-4).
India
adolescents
prediabetes
rural
undernutrition
Journal
Frontiers in public health
ISSN: 2296-2565
Titre abrégé: Front Public Health
Pays: Switzerland
ID NLM: 101616579
Informations de publication
Date de publication:
2023
2023
Historique:
received:
07
03
2023
accepted:
11
07
2023
medline:
22
8
2023
pubmed:
21
8
2023
entrez:
21
8
2023
Statut:
epublish
Résumé
India is witnessing an epidemic of type 2 diabetes. Overweight/obesity, overnutrition, physical inactivity, and family history are well-known risk factors for diabetes. We investigated the role of undernutrition in the development of diabetes among rural adolescent girls. DERVAN cohort study was set up in the KONKAN region of the western Indian state of Maharashtra. It enrolled 1,520 adolescent girls (16-18 years old at the time of enrollment). We measured glycemic parameters (glucose, insulin, and HbA The median age of the subjects was 16.6 years. The median weight, height, and BMI were 40.7 kg, 151.7 cm, and 17.5 kg/m We have reported a high prevalence of prediabetes among rural adolescent girls with a very low prevalence of obesity. Prediabetes in obesity is driven by hyperinsulinemia and overworking of the pancreas while poor β-cell function and poor insulin secretion are major drivers in the undernourished group. The high-risk diabetes screening programs are much needed for the undernourished populations. Caution should be exercised for planning the interventions as overfeeding (or overnutrition) is likely to put the populations at risk of development of obesity and insulin resistance.
Sections du résumé
Background
India is witnessing an epidemic of type 2 diabetes. Overweight/obesity, overnutrition, physical inactivity, and family history are well-known risk factors for diabetes. We investigated the role of undernutrition in the development of diabetes among rural adolescent girls.
Methods
DERVAN cohort study was set up in the KONKAN region of the western Indian state of Maharashtra. It enrolled 1,520 adolescent girls (16-18 years old at the time of enrollment). We measured glycemic parameters (glucose, insulin, and HbA
Results
The median age of the subjects was 16.6 years. The median weight, height, and BMI were 40.7 kg, 151.7 cm, and 17.5 kg/m
Conclusion
We have reported a high prevalence of prediabetes among rural adolescent girls with a very low prevalence of obesity. Prediabetes in obesity is driven by hyperinsulinemia and overworking of the pancreas while poor β-cell function and poor insulin secretion are major drivers in the undernourished group. The high-risk diabetes screening programs are much needed for the undernourished populations. Caution should be exercised for planning the interventions as overfeeding (or overnutrition) is likely to put the populations at risk of development of obesity and insulin resistance.
Identifiants
pubmed: 37601212
doi: 10.3389/fpubh.2023.1181401
pmc: PMC10435731
doi:
Substances chimiques
Insulins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1181401Informations de copyright
Copyright © 2023 Patil, Patil, Hardikar-Bhat, Dervankar, Joglekar, Bhat, Nandoskar, Yadav and Nilawar.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Diabetes Care. 2022 Jun 2;45(6):1428-1437
pubmed: 35522035
J Agric Food Chem. 2023 Jan 11;71(1):347-357
pubmed: 36541437
Diabetes Care. 2006 May;29(5):1130-9
pubmed: 16644654
Arch Physiol Biochem. 2015 Feb;121(1):26-31
pubmed: 25244251
Indian J Physiol Pharmacol. 2014 Jan-Mar;58(1):77-80
pubmed: 25464681
ISRN Endocrinol. 2012;2012:103472
pubmed: 22462011
J Family Med Prim Care. 2022 Jun;11(6):2474-2478
pubmed: 36119353
World J Diabetes. 2015 May 15;6(4):613-20
pubmed: 25987958
J Pediatr Nurs. 2020 Jan - Feb;50:94-104
pubmed: 31786470
Diabetes Res Clin Pract. 2022 Jan;183:109119
pubmed: 34879977
J Clin Diagn Res. 2015 Nov;9(11):SC09-12
pubmed: 26673888
Diabetes Care. 2007 Mar;30(3):753-9
pubmed: 17327355
Lancet. 2012 Jun 16;379(9833):2279-90
pubmed: 22683128
Pediatr Obes. 2012 Aug;7(4):284-94
pubmed: 22715120
Diabetes Care. 2020 Jan;43(Suppl 1):S14-S31
pubmed: 31862745
JAMA Pediatr. 2020 Feb 1;174(2):e194498
pubmed: 31790544
Obes Rev. 2019 Oct;20(10):1341-1349
pubmed: 31342672
BMJ Open. 2020 Sep 6;10(9):e035926
pubmed: 32895267
Lancet. 2009 Nov 14;374(9702):1677-86
pubmed: 19878986
Diabetologia. 2006 Feb;49(2):289-97
pubmed: 16391903
Diabet Med. 2007 Feb;24(2):200-7
pubmed: 17257284
Clin Diabetes Endocrinol. 2019 May 9;5:5
pubmed: 31086677
Diabetes Technol Ther. 2013 Jan;15(1):13-9
pubmed: 23151017
Pediatr Diabetes. 2020 Nov;21(7):1110-1115
pubmed: 32681534
Diabetes Care. 2019 Mar;42(3):476-485
pubmed: 30659076
Diabetes Technol Ther. 2020 Dec;22(12):875-882
pubmed: 32349530
World J Clin Cases. 2015 Feb 16;3(2):171-9
pubmed: 25685764
J Pediatr. 2014 Jun;164(6):1358-62.e2
pubmed: 24655536
BMC Pediatr. 2020 Jan 23;20(1):31
pubmed: 31973728
Metabolism. 1979 Nov;28(11):1086-96
pubmed: 386029
Lancet Reg Health Southeast Asia. 2023 May 02;14:100182
pubmed: 37492423
BMC Endocr Disord. 2021 Jul 7;21(1):146
pubmed: 34233661
Diabetologia. 1992 Jul;35(7):595-601
pubmed: 1644236
F1000Res. 2022 Jul 12;11:777
pubmed: 36300035
Diabetes Care. 2021 Dec;44(12):2747-2757
pubmed: 34610922
J Nutr. 2004 Jan;134(1):205-10
pubmed: 14704320