Evaluation of mechanistic serum and urine biomarkers for secondary osteoarthritis associated with developmental dysplasia of the hip.
Biomarker
Dysplasia
Mechanism
Osteoarthritis
Journal
Journal of orthopaedics
ISSN: 0972-978X
Titre abrégé: J Orthop
Pays: India
ID NLM: 101233220
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
16
03
2023
revised:
09
05
2023
accepted:
24
05
2023
pmc-release:
01
08
2024
medline:
21
8
2023
pubmed:
21
8
2023
entrez:
21
8
2023
Statut:
epublish
Résumé
Determine measurable differences for mechanistic urine and serum biomarkers in patients with developmental dysplasia of the hip (DDH) prior to, and following, secondary hip osteoarthritis (OA) when compared to controls. Urine and serum were collected from individuals with developmental dysplasia of the hip (n = 39), prior to (Pre-OA DDH, n = 32) and following diagnosis of secondary hip OA (Post-OA DDH, n = 7), age-matched Pre-OA controls (n = 35), and age-matched Post-OA controls (n = 12). Samples were analyzed for protein biomarkers with potential for differentiation of hip status through a Mann-Whitney Several interleukin and degradation related proteins were found to be differentially expressed when comparing DDH-related hip status prior to and following diagnosis of hip OA. In addition, MCP-1 and TIMP-1 were significantly different between younger and older patients in the control cohorts. These results provide initial evidence for serum and urine protein biomarkers that define clinically relevant stages of symptomatic DDH and its progression to secondary hip osteoarthritis categorized by known mechanisms of disease. III.
Identifiants
pubmed: 37601815
doi: 10.1016/j.jor.2023.05.010
pii: S0972-978X(23)00125-3
pmc: PMC10435905
doi:
Types de publication
Journal Article
Langues
eng
Pagination
24-29Informations de copyright
© 2023 Professor P K Surendran Memorial Education Foundation. Published by Elsevier B.V. All rights reserved.
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