Omega-3 index, cardiorespiratory fitness, and cognitive function in mid-age and older adults.

Adults Cardiorespiratory fitness Cognitive function Cognitive impairment Elderly Omega-3 index

Journal

Preventive medicine reports
ISSN: 2211-3355
Titre abrégé: Prev Med Rep
Pays: United States
ID NLM: 101643766

Informations de publication

Date de publication:
Oct 2023
Historique:
received: 24 03 2023
revised: 03 08 2023
accepted: 04 08 2023
medline: 21 8 2023
pubmed: 21 8 2023
entrez: 21 8 2023
Statut: epublish

Résumé

Higher levels of omega-3 fatty acids in red blood cell membranes (omega-3 index or O3I) and cardiorespiratory fitness (CRF) are each associated with reduced cognitive impairment, but little research has examined the relationship between O3I and cognitive function while accounting for CRF. We analyzed cross-sectional data from 5,464 healthy men and women aged 55-85 years who had preventive medical examinations between 2009 and 2023. Primary exposures included O3I (<4.0%, 4.0-7.9%, or ≥ 8.0%) and age- and sex-based CRF quintile (1 = low, 2-3 = moderate, 4-5 = high). Cognitive impairment was defined as a Montreal Cognitive Assessment score of ≤ 25. We used Poisson regression to estimate relative risks (RR) of cognitive impairment, controlling for covariates. O3I < 4% was associated with increased cognitive impairment relative to ≥ 8.0% (RR, 1.21; 95% CI, 1.01-1.44) in a partially adjusted model. This association did not remain statistically significant in the fully adjusted model which included CRF. Low versus high CRF was associated with cognitive impairment (RR, 1.28; 95% CI, 1.07-1.53), independent of O3I and clinical biomarkers. The interaction between CRF and O3I was not significant (

Identifiants

pubmed: 37601829
doi: 10.1016/j.pmedr.2023.102364
pii: S2211-3355(23)00255-3
pmc: PMC10432782
doi:

Types de publication

Journal Article

Langues

eng

Pagination

102364

Informations de copyright

© 2023 The Authors.

Déclaration de conflit d'intérêts

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. No external funding was provided for this study. The authors thank Kenneth H. Cooper, MD, MPH for establishing the Cooper Center Longitudinal Study, the Cooper Clinic physicians and staff for collecting clinical data, and The Cooper Institute for maintaining the database. Additionally, we are grateful to the CCLS participants.

Références

Rev Neurol (Paris). 2019 Dec;175(10):724-741
pubmed: 31521398
Prog Cardiovasc Dis. 2015 Jan-Feb;57(4):324-9
pubmed: 25269066
J Nutr Health Aging. 2021;25(4):454-461
pubmed: 33786562
Neurology. 2020 Aug 25;95(8):e995-e1007
pubmed: 32669395
J Am Coll Cardiol. 2020 Apr 7;75(13):1538-1547
pubmed: 32241369
Annu Rev Public Health. 2019 Apr 1;40:65-84
pubmed: 30642228
Nutrients. 2021 Dec 24;14(1):
pubmed: 35010946
Circulation. 2005 Jul 26;112(4):505-12
pubmed: 16009797
Prev Med. 2004 Jul;39(1):212-20
pubmed: 15208005
J Aging Phys Act. 2021 Jan 03;29(5):878-885
pubmed: 33395631
Am Heart J. 1982 Mar;103(3):363-73
pubmed: 7064770
Prog Lipid Res. 2009 Sep;48(5):239-56
pubmed: 19362576
Mayo Clin Proc. 2015 Nov;90(11):1524-32
pubmed: 26422243
Atherosclerosis. 2017 Jul;262:51-54
pubmed: 28511049
Prostaglandins Leukot Essent Fatty Acids. 2021 Nov;174:102361
pubmed: 34740031
Prev Chronic Dis. 2016 Dec 29;13:E181
pubmed: 28033088
Neurology. 2012 Feb 28;78(9):658-64
pubmed: 22371413
SSM Popul Health. 2020 Mar 31;11:100577
pubmed: 32300635
J Alzheimers Dis. 2019;68(3):961-968
pubmed: 30814346
JAMA. 2002 Sep 25;288(12):1475-83
pubmed: 12243634
J Alzheimers Dis. 2019;67(3):795-819
pubmed: 30776012
Gerontology. 2018;64(5):440-445
pubmed: 29843126
Nutr Rev. 2020 Jul 1;78(7):563-578
pubmed: 31841161
Am Heart J. 1976 Jul;92(1):39-46
pubmed: 961576
J Am Heart Assoc. 2022 Jun 7;11(11):e025071
pubmed: 35647665
J Aging Phys Act. 2021 Aug 27;30(3):355-363
pubmed: 34453026
J Am Geriatr Soc. 2005 Apr;53(4):695-9
pubmed: 15817019
Lipids Health Dis. 2019 Nov 6;18(1):194
pubmed: 31694658
Am J Epidemiol. 2004 Apr 1;159(7):702-6
pubmed: 15033648
Prev Med Rep. 2022 Dec;30:102065
pubmed: 36439400
Eur J Nutr. 2022 Mar;61(2):589-604
pubmed: 34392394
Med Sci Sports Exerc. 2011 Nov;43(11):2134-9
pubmed: 21448076
Nutrients. 2018 Sep 06;10(9):
pubmed: 30200655
Prostaglandins Leukot Essent Fatty Acids. 2017 Jun;121:68-75
pubmed: 28651700
Neuropharmacology. 2013 Jan;64:550-65
pubmed: 22841917
Curr Sports Med Rep. 2013 Jul-Aug;12(4):215-7
pubmed: 23851406
Life Sci. 2018 Jun 15;203:255-267
pubmed: 29715470
Neurology. 2022 Oct 5;:
pubmed: 36198518
Am J Clin Nutr. 2022 Dec 19;116(6):1492-1506
pubmed: 36253968
Mil Med. 2014 Apr;179(4):396-403
pubmed: 24690964
Neurology. 2014 Feb 4;82(5):435-42
pubmed: 24453077
Alzheimers Dement. 2021 Dec;17(12):1966-1975
pubmed: 34043283
Oxid Med Cell Longev. 2019 Sep 4;2019:9874159
pubmed: 31565158

Auteurs

Kimberly N Doughty (KN)

Marion Peckham Egan School of Nursing & Health Studies, Fairfield University, Fairfield, CT, USA.

Juliana Blazek (J)

Department of Research, The Cooper Institute, Dallas, TX, USA.

David Leonard (D)

Department of Research, The Cooper Institute, Dallas, TX, USA.

Carolyn E Barlow (CE)

Department of Research, The Cooper Institute, Dallas, TX, USA.

Laura F DeFina (LF)

Department of Research, The Cooper Institute, Dallas, TX, USA.
Flexible Minds, Nijmegen, the Netherlands.

Stephen W Farrell (SW)

Department of Research, The Cooper Institute, Dallas, TX, USA.

Kerem Shuval (K)

Department of Research, The Cooper Institute, Dallas, TX, USA.

Classifications MeSH