Exploring the potential of propanamide-sulfonamide based drug conjugates as dual inhibitors of urease and cyclooxygenase-2: biological and their
NSAIDs
cyclooxygenase-2
in-silico studies
inflammation
sulfonamides
urease
Journal
Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988
Informations de publication
Date de publication:
2023
2023
Historique:
received:
15
04
2023
accepted:
25
07
2023
medline:
21
8
2023
pubmed:
21
8
2023
entrez:
21
8
2023
Statut:
epublish
Résumé
Derivative synthesis has been a crucial method for altering the effects of already-approved medications, especially to lessen adverse effects and enhance results. Making use of this multi-target approach, a series of naproxen-sulfa drug conjugates was designed and synthesized. The newly designed conjugates were confirmed by spectroscopic techniques like IR,
Identifiants
pubmed: 37601915
doi: 10.3389/fchem.2023.1206380
pii: 1206380
pmc: PMC10434765
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1206380Informations de copyright
Copyright © 2023 Ahmad, Abdul Qadir, Ahmed, Imran, Yousaf, Wani, Zargar, Ali and Muddassar.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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