A new Hoxb8FlpO mouse line for intersectional approaches to dissect developmentally defined adult sensorimotor circuits.
dorsal root ganglion (DRG)
genetic tools
neuroscience
sensorimotor system
spinal cord
Journal
Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914
Informations de publication
Date de publication:
2023
2023
Historique:
received:
28
02
2023
accepted:
04
07
2023
medline:
21
8
2023
pubmed:
21
8
2023
entrez:
21
8
2023
Statut:
epublish
Résumé
Improvements in the speed and cost of expression profiling of neuronal tissues offer an unprecedented opportunity to define ever finer subgroups of neurons for functional studies. In the spinal cord, single cell RNA sequencing studies support decades of work on spinal cord lineage studies, offering a unique opportunity to probe adult function based on developmental lineage. While Cre/Flp recombinase intersectional strategies remain a powerful tool to manipulate spinal neurons, the field lacks genetic tools and strategies to restrict manipulations to the adult mouse spinal cord at the speed at which new tools develop. This study establishes a new workflow for intersectional mouse-viral strategies to dissect adult spinal function based on developmental lineages in a modular fashion. To restrict manipulations to the spinal cord, we generate a brain-sparing
Identifiants
pubmed: 37603775
doi: 10.3389/fnmol.2023.1176823
pmc: PMC10437123
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1176823Subventions
Organisme : NINDS NIH HHS
ID : K01 NS116224
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS119268
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM135141
Pays : United States
Informations de copyright
Copyright © 2023 Bohic, Upadhyay, Eisdorfer, Keating, Simon, Briones, Azadegan, Nacht, Oputa, Martinez, Bethell, Gradwell, Romanienko, Ramer, Stuber and Abraira.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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