Pancreatic acinar cell fate relies on system x
Journal
Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092
Informations de publication
Date de publication:
21 08 2023
21 08 2023
Historique:
received:
14
03
2023
accepted:
14
08
2023
revised:
28
07
2023
medline:
23
8
2023
pubmed:
22
8
2023
entrez:
21
8
2023
Statut:
epublish
Résumé
Acinar cell dedifferentiation is one of the most notable features of acute and chronic pancreatitis. It can also be the initial step that facilitates pancreatic cancer development. In the present study, we further decipher the precise mechanisms and regulation using primary human cells and murine experimental models. Our RNAseq analysis indicates that, in both species, early acinar cell dedifferentiation is accompanied by multiple pathways related to cell survival that are highly enriched, and where SLC7A11 (xCT) is transiently upregulated. xCT is the specific subunit of the cystine/glutamate antiporter system x
Identifiants
pubmed: 37604805
doi: 10.1038/s41419-023-06063-w
pii: 10.1038/s41419-023-06063-w
pmc: PMC10442358
doi:
Substances chimiques
Reactive Oxygen Species
0
Glutamic Acid
3KX376GY7L
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
536Informations de copyright
© 2023. The Author(s).
Références
Cancer Cell. 2013 Mar 18;23(3):406-20
pubmed: 23453624
Antioxidants (Basel). 2022 Jan 08;11(1):
pubmed: 35052641
J Clin Invest. 2020 Apr 1;130(4):1752-1766
pubmed: 31874110
Gut. 2014 Apr;63(4):656-64
pubmed: 23645620
Elife. 2015 Jul 07;4:
pubmed: 26151762
Proc Natl Acad Sci U S A. 2019 May 7;116(19):9433-9442
pubmed: 31000598
Cell Mol Gastroenterol Hepatol. 2019;8(3):379-405
pubmed: 31071489
ACS Cent Sci. 2017 Mar 22;3(3):232-243
pubmed: 28386601
Clin Gastroenterol Hepatol. 2009 Nov;7(11 Suppl):S40-3
pubmed: 19896097
ACS Chem Biol. 2020 Feb 21;15(2):469-484
pubmed: 31899616
J Biol Chem. 2005 Nov 11;280(45):37423-9
pubmed: 16144837
Gastroenterology. 2007 Mar;132(3):1127-51
pubmed: 17383433
Nat Commun. 2021 Mar 11;12(1):1589
pubmed: 33707434
Cancer Commun (Lond). 2018 Apr 25;38(1):12
pubmed: 29764521
J Clin Invest. 2021 Nov 15;131(22):
pubmed: 34609966
Gut. 2015 Nov;64(11):1790-9
pubmed: 25336113
Genes Dev. 2014 Dec 1;28(23):2621-35
pubmed: 25452273
Cell Rep. 2016 Mar 15;14(10):2325-36
pubmed: 26947075
Cell Mol Gastroenterol Hepatol. 2017 May 31;4(2):263-282
pubmed: 28752115
Sci Rep. 2018 Jan 17;8(1):968
pubmed: 29343855
Sci Rep. 2019 Mar 11;9(1):4040
pubmed: 30858455
Cell Res. 2020 Feb;30(2):146-162
pubmed: 31949285
J Endocrinol. 2007 May;193(2):195-207
pubmed: 17470511
Cell Death Dis. 2020 Oct 27;11(10):922
pubmed: 33110056
Oncotarget. 2016 Nov 22;7(47):77838-77853
pubmed: 27788482
Biomed Res Int. 2019 Dec 16;2019:2325765
pubmed: 31950034
Cell. 2014 Jan 16;156(1-2):317-331
pubmed: 24439385
Biochem Biophys Res Commun. 2016 Sep 23;478(3):1338-43
pubmed: 27565726
Nat Commun. 2020 Sep 9;11(1):4516
pubmed: 32908137
Genes Dev. 2016 Dec 15;30(24):2669-2683
pubmed: 28087712
J Clin Invest. 2021 Jul 1;131(13):
pubmed: 34032634
Dev Cell. 2019 Sep 23;50(6):744-754.e4
pubmed: 31422917
Blood. 2011 Jun 9;117(23):6202-13
pubmed: 21474670
Gastroenterology. 2002 Oct;123(4):1311-22
pubmed: 12360491
Leukemia. 2001 Oct;15(10):1633-40
pubmed: 11587223
Antioxidants (Basel). 2022 Dec 31;12(1):
pubmed: 36670963
Gut. 2011 Jul;60(7):958-66
pubmed: 21193456
Cell Death Dis. 2021 Jun 7;12(6):585
pubmed: 34099637
Annu Rev Physiol. 2015;77:229-49
pubmed: 25386992
Int J Mol Med. 2023 Jan;51(1):
pubmed: 36484371
Cancers (Basel). 2021 Mar 21;13(6):
pubmed: 33801101
Glia. 2018 Sep;66(9):1845-1861
pubmed: 29693305
Cancer Discov. 2019 Dec;9(12):1673-1685
pubmed: 31554642
Gastroenterology. 2014 Mar;146(3):822-834.e7
pubmed: 24315826
Nat Rev Gastroenterol Hepatol. 2017 May;14(5):296-304
pubmed: 28270694
Cell Mol Gastroenterol Hepatol. 2022;13(4):1243-1253
pubmed: 34875393
Redox Biol. 2015 Dec;6:51-72
pubmed: 26184557
Cell Death Differ. 2021 Sep;28(9):2601-2615
pubmed: 33762742
Cancer Res. 2021 May 15;81(10):2679-2689
pubmed: 33602788
Front Oncol. 2022 Feb 23;12:858462
pubmed: 35280777
Inhal Toxicol. 2012 Jul;24(8):476-85
pubmed: 22697888
Science. 2020 Apr 3;368(6486):85-89
pubmed: 32241947
Cell Cycle. 2011 Apr 15;10(8):1312-21
pubmed: 21490434
Nature. 2015 Apr 2;520(7545):57-62
pubmed: 25799988
Nature. 2018 Feb 22;554(7693):533-537
pubmed: 29443959
Int J Cancer. 2020 Dec 1;147(11):3224-3235
pubmed: 32818320
Antioxidants (Basel). 2021 Jul 11;10(7):
pubmed: 34356340
Cell Death Dis. 2020 Feb 3;11(2):88
pubmed: 32015325
Cell Mol Gastroenterol Hepatol. 2022;13(2):483-500
pubmed: 34562639
Onco Targets Ther. 2020 Jun 11;13:5429-5441
pubmed: 32606760
Gastroenterology. 2020 Jun;158(8):2072-2081
pubmed: 32199881
Front Cell Dev Biol. 2021 May 17;9:663906
pubmed: 34079799
Cancer Res. 2019 Aug 1;79(15):3877-3890
pubmed: 31175120
Gut. 2012 Mar;61(3):449-58
pubmed: 21730103
Biomed Pharmacother. 2020 Nov;131:110693
pubmed: 32882586
Cell. 2012 May 25;149(5):1060-72
pubmed: 22632970
Gastroenterology. 2011 Aug;141(2):731-41, 741.e1-4
pubmed: 21703267