A stable and replicable neural signature of lifespan adversity in the adult brain.

Adult Humans Longevity Brain Anxiety Mental Disorders Neurobiology

Journal

Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671

Informations de publication

Date de publication:
09 2023
Historique:
received: 30 08 2022
accepted: 17 07 2023
medline: 4 9 2023
pubmed: 22 8 2023
entrez: 21 8 2023
Statut: ppublish

Résumé

Environmental adversities constitute potent risk factors for psychiatric disorders. Evidence suggests the brain adapts to adversity, possibly in an adversity-type and region-specific manner. However, the long-term effects of adversity on brain structure and the association of individual neurobiological heterogeneity with behavior have yet to be elucidated. Here we estimated normative models of structural brain development based on a lifespan adversity profile in a longitudinal at-risk cohort aged 25 years (n = 169). This revealed widespread morphometric changes in the brain, with partially adversity-specific features. This pattern was replicated at the age of 33 years (n = 114) and in an independent sample at 22 years (n = 115). At the individual level, greater volume contractions relative to the model were predictive of future anxiety. We show a stable neurobiological signature of adversity that persists into adulthood and emphasize the importance of considering individual-level rather than group-level predictions to explain emerging psychopathology.

Identifiants

DOI: 10.1038/s41593-023-01410-8 PMID: 37604888 PMC: PMC10471497
pubmed: 37604888
doi: 10.1038/s41593-023-01410-8
pii: 10.1038/s41593-023-01410-8
pmc: PMC10471497
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1603-1612

Subventions

Organisme : MRF
ID : MRF_MRF-058-0004-RG-DESRI
Pays : United Kingdom
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG058854
Pays : United States
Organisme : Medical Research Council
ID : MR/W002418/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S020306/1
Pays : United Kingdom
Organisme : MRF
ID : MRF_MRF-058-0009-RG-DESR-C0759
Pays : United Kingdom
Organisme : NIDA NIH HHS
ID : R01 DA049238
Pays : United States
Organisme : Medical Research Council
ID : MR/R00465X/1
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH085772
Pays : United States

Investigateurs

Jean-Luc Martinot (JL)
Marie-Laure Paillère Martinot (ML)
Juliane H Fröhner (JH)
Michael N Smolka (MN)
Henrik Walter (H)

Informations de copyright

© 2023. The Author(s).

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Auteurs

Nathalie E Holz (NE)

Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, the Netherlands. nathalie.holz@zi-mannheim.de.
Department for Cognitive Neuroscience, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands. nathalie.holz@zi-mannheim.de.
Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany. nathalie.holz@zi-mannheim.de.
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. nathalie.holz@zi-mannheim.de.
ORCID: 0000-0002-6225-9267

Mariam Zabihi (M)

Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, the Netherlands.
Department for Cognitive Neuroscience, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands.
MRC Unit for Lifelong Health & Ageing, University College London (UCL), London, UK.
ORCID: 0000-0002-7083-2318

Seyed Mostafa Kia (SM)

Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, the Netherlands.
Department for Cognitive Neuroscience, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands.
Department of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands.
ORCID: 0000-0002-7128-814X

Maximillian Monninger (M)

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Pascal-M Aggensteiner (PM)

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Sebastian Siehl (S)

Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany.
ORCID: 0000-0002-8933-7552

Dorothea L Floris (DL)

Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, the Netherlands.
Department for Cognitive Neuroscience, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands.
Methods of Plasticity Research, Department of Psychology, University of Zurich, Zurich, Switzerland.

Arun L W Bokde (ALW)

Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
ORCID: 0000-0003-0114-4914

Sylvane Desrivières (S)

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
ORCID: 0000-0002-9120-7060

Herta Flor (H)

Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
ORCID: 0000-0003-4809-5398

Antoine Grigis (A)

NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.

Hugh Garavan (H)

Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.

Penny Gowland (P)

Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK.
ORCID: 0000-0002-4900-4817

Andreas Heinz (A)

Department of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
ORCID: 0000-0001-5405-9065

Rüdiger Brühl (R)

Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Berlin, Germany.
ORCID: 0000-0003-0111-5996

Jean-Luc Martinot (JL)

Institut National de la Santé et de la Recherche Médicale, INSERM U1299 'Developmental Trajectories & Psychiatry'; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, France.

Marie-Laure Paillère Martinot (MP)

Institut National de la Santé et de la Recherche Médicale, INSERM U1299 'Developmental Trajectories & Psychiatry'; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, France.
Institut National de la Santé et de la Recherche Médicale, INSERM U1299 'Developmental Trajectories & Psychiatry'; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette; and AP-HP.Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, France.
ORCID: 0000-0002-0452-2450

Dimitri Papadopoulos Orfanos (DP)

NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.
ORCID: 0000-0002-1242-8990

Tomáš Paus (T)

Departments of Psychiatry and Neuroscience and Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.
Departments of Psychiatry and Psychology, University of Toronto, Toronto, Ontario, Canada.

Luise Poustka (L)

Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, Heidelberg University, Heidelberg, Germany.
Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, Germany.

Juliane H Fröhner (JH)

Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
ORCID: 0000-0002-8493-6396

Michael N Smolka (MN)

Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
ORCID: 0000-0001-5398-5569

Nilakshi Vaidya (N)

PONS-Centre, Department of Psychiatry and Clinical Neuroscience, CCM, Charite University Medicine, Berlin, Germany.

Henrik Walter (H)

Department of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
ORCID: 0000-0002-9403-6121

Robert Whelan (R)

School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
ORCID: 0000-0002-2790-7281

Gunter Schumann (G)

PONS-Centre, Department of Psychiatry and Clinical Neuroscience, CCM, Charite University Medicine, Berlin, Germany.
Centre for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, China.
ORCID: 0000-0002-7740-6469

Andreas Meyer-Lindenberg (A)

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
ORCID: 0000-0001-5619-1123

Daniel Brandeis (D)

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.
Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.

Jan K Buitelaar (JK)

Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, the Netherlands.
Department for Cognitive Neuroscience, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands.
Karakter Child and Adolescent Psychiatry University Center, Nijmegen, The Netherlands.
ORCID: 0000-0001-8288-7757

Frauke Nees (F)

Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany.
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Christian Beckmann (C)

Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, the Netherlands.
Department for Cognitive Neuroscience, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands.
Centre for Functional MRI of the Brain, University of Oxford, Oxford, UK.

Tobias Banaschewski (T)

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Andre F Marquand (AF)

Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, the Netherlands. a.marquand@donders.ru.nl.
Department for Cognitive Neuroscience, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands. a.marquand@donders.ru.nl.
Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. a.marquand@donders.ru.nl.

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Classifications MeSH

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