Defining and unpacking the core concepts of pharmacology: A global initiative.

Delphi method core concept curriculum development health science education pharmacology education science education sub-concept

Journal

British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536

Informations de publication

Date de publication:
22 Aug 2023
Historique:
revised: 11 07 2023
received: 04 04 2023
accepted: 08 08 2023
pubmed: 22 8 2023
medline: 22 8 2023
entrez: 22 8 2023
Statut: aheadofprint

Résumé

Development of core concepts in disciplines such as biochemistry, microbiology and physiology have transformed teaching. They provide the foundation for the development of teaching resources for global educators, as well as valid and reliable approaches to assessment. An international research consensus recently identified 25 core concepts of pharmacology. The current study aimed to define and unpack these concepts. A two-phase, iterative approach, involving 60 international pharmacology education experts, was used. The first phase involved drafting definitions for core concepts and identifying key sub-concepts via a series of online meetings and asynchronous work. These were refined in the second phase, through a 2-day hybrid workshop followed by a further series of online meetings and asynchronous work. The project produced consensus definitions for a final list of 24 core concepts and 103 sub-concepts of pharmacology. The iterative, discursive methodology resulted in modification of concepts from the original study, including change of 'drug-receptor interaction' to 'drug-target interaction' and the change of the core concept 'agonists and antagonists' to sub-concepts of drug-target interaction. Definitions and sub-concepts of 24 core concepts provide an evidence-based foundation for pharmacology curricula development and evaluation. The next steps for this project include the development of a concept inventory to assess acquisition of concepts, as well as the development of case studies and educational resources to support teaching by the global pharmacology community, and student learning of the most critical and fundamental concepts of the discipline.

Sections du résumé

BACKGROUND AND PURPOSE OBJECTIVE
Development of core concepts in disciplines such as biochemistry, microbiology and physiology have transformed teaching. They provide the foundation for the development of teaching resources for global educators, as well as valid and reliable approaches to assessment. An international research consensus recently identified 25 core concepts of pharmacology. The current study aimed to define and unpack these concepts.
EXPERIMENTAL APPROACH METHODS
A two-phase, iterative approach, involving 60 international pharmacology education experts, was used. The first phase involved drafting definitions for core concepts and identifying key sub-concepts via a series of online meetings and asynchronous work. These were refined in the second phase, through a 2-day hybrid workshop followed by a further series of online meetings and asynchronous work.
KEY RESULTS RESULTS
The project produced consensus definitions for a final list of 24 core concepts and 103 sub-concepts of pharmacology. The iterative, discursive methodology resulted in modification of concepts from the original study, including change of 'drug-receptor interaction' to 'drug-target interaction' and the change of the core concept 'agonists and antagonists' to sub-concepts of drug-target interaction.
CONCLUSIONS AND IMPLICATIONS CONCLUSIONS
Definitions and sub-concepts of 24 core concepts provide an evidence-based foundation for pharmacology curricula development and evaluation. The next steps for this project include the development of a concept inventory to assess acquisition of concepts, as well as the development of case studies and educational resources to support teaching by the global pharmacology community, and student learning of the most critical and fundamental concepts of the discipline.

Identifiants

pubmed: 37605852
doi: 10.1111/bph.16222
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2023 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.

Références

(BDA)., B. D. A. (2023). About dyscalculia. Retrieved from https://www.bdadyslexia.org.uk/dyscalculia/how-can-i-identify-dyscalculia
Alexander, S. P. H., Christopoulos, A., Davenport, A. P., Kelly, E., Mathie, A., Peters, J. A., Veale, E. L., Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., Southan, C., Davies, J. A., Abbracchio, M. P., Alexander, W., Al-Hosaini, K., Bäck, M., Barnes, N. M., Bathgate, R., … Ye, R. D. (2021). The Concise Guide to PHARMACOLOGY 2021/22: G protein-coupled receptors. British Journal of Pharmacology, 178, S27-S156. https://doi.org/10.1111/bph.15538
AMSPC, A. (2022). Pharmacology knowledge objectives. Retrieved from https://amspc.org/resources/Documents/KOs%20Final-2022%20edition-01092023.pdf
Ausubel, D. P. (1963). The psychology of meaningful verbal learning. Grune & Stratton.
Bassett, A. M., Brosnan, C., Southgate, E., & Lempp, H. (2018). Transitional journeys into, and through medical education for first-in-family (FiF) students: A qualitative interview study. BMC Medical Education, 18(1), 102. https://doi.org/10.1186/s12909-018-1217-z
Beatty, J. (2006). Masking disagreement among experts. Episteme, 3(1-2), 52-67.
Bradley, C. L., Schwartz, S. E., & Cooper, J. B. (2021). Communicating definitive uncertainty: Teaching pharmacy students to say “I don't know”. Currents in Pharmacy Teaching and Learning, 13(8), 1032-1039. https://doi.org/10.1016/j.cptl.2021.06.020
Brewer, C. A., & Smith, D. (2011). Vision and change in undergraduate biology education: A call to action (p. 81). American Association for the Advancement of Science.
Brownell, S. E., Freeman, S., Wenderoth, M. P., & Crowe, A. J. (2014). BioCore guide: A tool for interpreting the core concepts of vision and change for biology majors. CBE-Life Sciences Education, 13(2), 200-211. https://doi.org/10.1187/cbe.13-12-0233
Cernusca, D., & Strand, M. (n.d.). Exploratory steps to stimulate a deep learning micro-culture. Introducing concept mapping strategies into a pharmacy curriculum. rdannual, 69. https://members.aect.org/pdf/Proceedings/proceedings20/2020/20_07.pdf
Chazan, D., Sela, H., & Herbst, P. (2012). Is the role of equations in the doing of word problems in school algebra changing? Initial indications from teacher study groups. Cognition and Instruction, 30(1), 1-38. https://doi.org/10.1080/07370008.2011.636593
Chitnis, N., & Smith, T. A. (2012). Mathematical illiteracy impedes progress in biology. Proceedings of the National Academy of Sciences, 109(45), E3055. https://doi.org/10.1073/pnas.1213115109
Colquhoun, D. (2006). The quantitative analysis of drug-receptor interactions: A short history. Trends in Pharmacological Sciences, 27(3), 149-157. https://doi.org/10.1016/j.tips.2006.01.008
Faccenda, E., Maxwell, S., & Szarek, J. L. (2019). The IUPHAR Pharmacology Education Project. Clinical Pharmacology & Therapeutics, 105(1), 45-48. https://doi.org/10.1002/cpt.1278
Fawcett, T. W., & Higginson, A. D. (2012). Heavy use of equations impedes communication among biologists. Proceedings of the National Academy of Sciences, 109(29), 11735-11739. https://doi.org/10.1073/pnas.1205259109
Fernandes, A. D. (2012). No evidence that equations cause impeded communication among biologists. Proceedings of the National Academy of Sciences, 109(45), E3057. https://doi.org/10.1073/pnas.1211892109
Frank, J. R., Snell, L. S., Cate, O. T., Holmboe, E. S., Carraccio, C., Swing, S. R., Harris, K. A., Glasgow, N. J., Campbell, C., Dath, D., Harden, R. M., Iobst, W., Long, D. M., Mungroo, R., Richardson, D. L., Sherbino, J., Silver, I., Taber, S., Talbot, M., & Harris, K. A. (2010). Competency-based medical education: Theory to practice. Medical Teacher, 32(8), 638-645. https://doi.org/10.3109/0142159X.2010.501190
Gibbons, J. (2012). Do not throw equations out with the theory bathwater. Proceedings of the National Academy of Sciences, 109(45), E3054. https://doi.org/10.1073/pnas.1212498109
Hestenes, D., Wells, M., & Swackhamer, G. (1992). Force concept inventory. The Physics Teacher, 30(3), 141-158. https://doi.org/10.1119/1.2343497
Hill, A. V. (1909). The mode of action of nicotine and curari, determined by the form of the contraction curve and the method of temperature coefficients. The Journal of Physiology, 39(5), 361-373. https://doi.org/10.1113/jphysiol.1909.sp001344
Hott, A. M., Huether, C. A., Mcinerney, J. D., Christianson, C., Fowler, R., Bender, H., Jenkins, J., Wysocki, A., Markle, G., & Karp, R. (2002). Genetics content in introductory biology courses for non-science majors: Theory and practice. Bioscience, 52(11), 1024-1035. https://doi.org/10.1641/0006-3568(2002)052[1024:GCIIBC]2.0.CO;2
IUPHAR, C. C. o. P. (2022). Concept-based pharmacology education workshop-18-20 July 2022. Retrieved from https://coreconceptspharmacology.org/2022/04/08/concept-based-pharmacology-education-workshop-18-20-july-2022/
Kane, A. (2012). A suggestion on improving mathematically heavy papers. Proceedings of the National Academy of Sciences, 109(45), E3056. https://doi.org/10.1073/pnas.1212310109
Kinchin, I. M. (2003). Effective teacher ↔ student dialogue: A model from biological education. Journal of Biological Education, 37(3), 110-113. https://doi.org/10.1080/00219266.2003.9655864
Koenig, J., & Pike, N. (2013). Perspectives from the UK and the US on integrating mathematics into the teaching and learning of the biological sciences in higher education. Retrieved from https://www.advance-he.ac.uk/knowledge-hub/perspectives-uk-and-us-integrating-mathematics-teaching-and-learning-biological
Machado, C. T., & Carvalho, A. A. (2020). Concept mapping: Benefits and challenges in higher education. The Journal of Continuing Higher Education, 68(1), 38-53. https://doi.org/10.1080/07377363.2020.1712579
McMillan, J., & Edwards, D. (2019). Performance in first year mathematics and science subjects in Australian universities: Does senior secondary mathematics background matter? Final Report.
Michael, J., Cliff, W., McFarland, J., Modell, H., & Wright, A. (2017). What are the core concepts of physiology? In The core concepts of physiology (pp. 27-36). Springer. https://doi.org/10.1007/978-1-4939-6909-8_3
Michael, J., Cliff, W., McFarland, J., Modell, H., Wright, A., Michael, J., Cliff, W., McFarland, J., Modell, H., & Wright, A. (2017). What does it mean to “unpack” a core concept? The core concepts of physiology (pp. 37-44). https://doi.org/10.1007/978-1-4939-6909-8_4
Michael, J., Martinkova, P., McFarland, J., Wright, A., Cliff, W., Modell, H., & Wenderoth, M. P. (2017). Validating a conceptual framework for the core concept of “cell-cell communication”. Advances in Physiology Education, 41(2), 260-265. https://doi.org/10.1152/advan.00100.2016
Mulford, D. R., & Robinson, W. R. (2002). An inventory for alternate conceptions among first-semester general chemistry students. Journal of Chemical Education, 79(6), 739. https://doi.org/10.1021/ed079p739
Noble, C., O'Brien, M., Coombes, I., Shaw, P. N., & Nissen, L. (2011). Concept mapping to evaluate an undergraduate pharmacy curriculum. American Journal of Pharmaceutical Education, 75(3), 55. https://doi.org/10.5688/ajpe75355
Novak, J. D. (1990). Concept mapping: A useful tool for science education. Journal of Research in Science Teaching, 27(10), 937-949. https://doi.org/10.1002/tea.3660271003
Novak, J. D., & Gowin, D. B. (1984). Learning how to learn. Cambridge University Press. https://doi.org/10.1017/CBO9781139173469
Patel, P., Hancock, J., Rogers, M., & Pollard, S. R. (2022). Improving uncertainty tolerance in medical students: A scoping review. Medical Education, 56(12), 1163-1173. https://doi.org/10.1111/medu.14873
Project, I. C. C. o. P. E. (2022). The International Core Concepts of Pharmacology Education Project. Retrieved from https://coreconceptspharmacology.org/
QAA. (2023). Biomedical science and biomedical sciences subject benchmark statements. Retrieved from https://www.qaa.ac.uk/the-quality-code/subject-benchmark-statements/subject-benchmark-statement-biomedical-science-and-biomedical-sciences
Quesnelle, K. M., Zaveri, N. T., Schneid, S. D., Blumer, J. B., Szarek, J. L., Kruidering, M., & Lee, M. W. (2021). Design of a foundational sciences curriculum: Applying the ICAP framework to pharmacology education in integrated medical curricula. Pharmacology Research & Perspectives, 9(3), e00762. https://doi.org/10.1002/prp2.762
Rang, H. P. (2006). The receptor concept: Pharmacology's big idea. British Journal of Pharmacology, 147, S9-S16. https://doi.org/10.1038/sj.bjp.0706457
Rosenberg, J. M., Kubsch, M., Wagenmakers, E.-J., & Dogucu, M. (2022). Making sense of uncertainty in the science classroom. Science & Education, 31(5), 1239-1262. https://doi.org/10.1007/s11191-022-00341-3
Ross, S., & Maxwell, S. (2012). Prescribing and the core curriculum for tomorrow's doctors: BPS curriculum in clinical pharmacology and prescribing for medical students. British Journal of Clinical Pharmacology, 74(4), 644-661. https://doi.org/10.1111/j.1365-2125.2012.04186.x
Rylands, L. J., & Coady, C. (2009). Performance of students with weak mathematics in first-year mathematics and science. International Journal of Mathematical Education in Science and Technology, 40(6), 741-753. https://doi.org/10.1080/00207390902914130
Santiago, M., Davis, E. A., Hinton, T., Angelo, T. A., Shield, A., Babey, A.-M., Kemp-Harper, B., Maynard, G., al-Sallami, H. S., Musgrave, I. F., Fernandes, L. B., Ngo, S. N. T., Christopoulos, A., & White, P. J. (2021). Defining and unpacking the core concepts of pharmacology education. Pharmacology Research & Perspectives, 9(6), e00894. https://doi.org/10.1002/prp2.894
Santos, R., Ursu, O., Gaulton, A., Bento, A. P., Donadi, R. S., Bologa, C. G., Karlsson, A., al-Lazikani, B., Hersey, A., Oprea, T. I., & Overington, J. P. (2017). A comprehensive map of molecular drug targets. Nature Reviews. Drug Discovery, 16(1), 19-34. https://doi.org/10.1038/nrd.2016.230
Scott, A., Sudlow, M., Shaw, E., & Fisher, J. (2020). Medical education, simulation and uncertainty. The Clinical Teacher, 17(5), 497-502. https://doi.org/10.1111/tct.13119
Shaywitz, S. E., Shaywitz, J. E., & Shaywitz, B. A. (2021). Dyslexia in the 21st century. Current Opinion in Psychiatry, 34(2), 80-86. https://doi.org/10.1097/YCO.0000000000000670
Slominski, T., Fugleberg, A., Christensen, W. M., Buncher, J. B., & Momsen, J. L. (2020). Using framing as a lens to understand context effects on expert reasoning. CBE-Life Sciences Education, 19(3), ar48. https://doi.org/10.1187/cbe.19-11-0230
Stopford, R. (2021). Threshold concepts and certainty: A critical analysis of ‘troublesomeness’. Higher Education, 82(1), 163-179. https://doi.org/10.1007/s10734-020-00628-w
Tansey, J. T., Baird, T. Jr., Cox, M. M., Fox, K. M., Knight, J., Sears, D., & Bell, E. (2013). Foundational concepts and underlying theories for majors in “biochemistry and molecular biology”. Biochemistry and Molecular Biology Education, 41(5), 289-296. https://doi.org/10.1002/bmb.20727
Tucker, S., Zecharia, A., Guilding, C., Engel, K., & Page, L. (2022). Recognising and redressing inequity and bias through pharmacology education: A modern, practical and inclusive curriculum. Pharmacology Matters. Retrieved from https://www.bps.ac.uk/publishing/pharmacology-matters/august-2022/recognising-and-redressing-inequity-and-bias-throu
Wallace, M. J., Zecharia, A., Guilding, C., Tucker, S., & McFadzean, I. (2021). Developing a new undergraduate pharmacology core curriculum: The British Pharmacological Society Delphi Method. Pharmacology Research & Perspectives, 9(4), e00832. https://doi.org/10.1002/prp2.832
Werners, A., & Fajt, V. (2021). What a veterinary graduate should know about basic and clinical pharmacology: A Delphi study to finalize day-1 competencies. Journal of Veterinary Pharmacology and Therapeutics, 44(4), 568-574. https://doi.org/10.1111/jvp.12920
White, P. J., Davis, E. A., Santiago, M., Angelo, T., Shield, A., Babey, A.-M., Kemp-Harper, B., Maynard, G., al-Sallami, H. S., Musgrave, I. F., Fernandes, L. B., Ngo, S. N. T., & Hinton, T. (2021). Identifying the core concepts of pharmacology education. Pharmacology Research & Perspectives, 9(4), e00836. https://doi.org/10.1002/prp2.836
White, P. J., Guilding, C., Angelo, T., Kelly, J., Gorman, L., Tucker, S., Fun, A., Han, J., Chen, G., Samak, Y., Babey, A. M., Caetano, F. A., Sarangi, S. C., Koenig, J., Hao, H., Goldfarb, J., Karpa, K., Vieira, L., Restini, C., … Liu, Y. (2023). Identifying the core concepts of pharmacology education: A global initiative. British Journal of Pharmacology, 180(9), 1197-1209. https://doi.org/10.1111/bph.16000
Witt, E. E., Onorato, S. E., & Schwartzstein, R. M. (2022). Medical students and the drive for a single right answer: Teaching complexity and uncertainty. ATS Scholar, 3(1), 27-37. https://doi.org/10.34197/ats-scholar.2021-0083PS

Auteurs

Clare Guilding (C)

School of Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

Paul J White (PJ)

Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

Margaret Cunningham (M)

Strathclyde Institute for Pharmacy and Biomedical Sciences (SIPBS), University of Strathclyde, Glasgow, UK.

Roisin Kelly-Laubscher (R)

Department of Pharmacology and Therapeutics, College of Medicine and Health, University College Cork, Cork, Ireland.

Jennifer Koenig (J)

School of Medicine, University of Nottingham, Nottingham, UK.

Anna-Marie Babey (AM)

Faculty of Medicine and Health, University of New England, Armidale, New South Wales, Australia.

Steve Tucker (S)

School of Medicine, Medical Science and Nutrition, University of Aberdeen, Aberdeen, UK.

John P Kelly (JP)

Department of Pharmacology and Therapeutics, School of Medicine, University of Galway, Galway, Ireland.

Laurel Gorman (L)

Department of Medical Education, University of Central Florida College of Medicine, Orlando, Florida, USA.
Department of Biomedical Education, Temple University, Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

Patrik Aronsson (P)

Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Martin Hawes (M)

Department of Comparative Biomedical Sciences, School of Veterinary Medicine, University of Surrey, Guildford, UK.

Suong N T Ngo (SNT)

School of Animal and Veterinary Science, Faculty of Sciences, Engineering and Technology, The University of Adelaide, Adelaide, South Australia, Australia.

Janet Mifsud (J)

Department of Clinical Pharmacology and Therapeutics, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.

Arend H Werners (AH)

School of Veterinary Medicine, St. George's University, True Blue, Grenada.

Tina Hinton (T)

Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.

Fouzia Khan (F)

National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK.

Mohamad Aljofan (M)

Department of Biomedical Science, School of Medicine Nazarbayev University, Astana, Kazakhstan.

Tom Angelo (T)

University of North Carolina, UNC Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA.

Classifications MeSH