Shadow of a Pandemic: Persistence of Prenatal SARS-CoV-2 Antibodies in Newborn Blood Spots.

COVID-19 SARS-CoV-2 antibody testing dried blood spots newborn newborn screening positive predictive value pregnancy prenatal seroprevalence serosurveillance

Journal

International journal of neonatal screening
ISSN: 2409-515X
Titre abrégé: Int J Neonatal Screen
Pays: Switzerland
ID NLM: 101665400

Informations de publication

Date de publication:
02 Aug 2023
Historique:
received: 25 06 2023
revised: 25 07 2023
accepted: 31 07 2023
medline: 22 8 2023
pubmed: 22 8 2023
entrez: 22 8 2023
Statut: epublish

Résumé

To investigate COVID-19 surveillance among pregnant women, the California Genetic Disease Screening Program conducted a screening performance and seroprevalence evaluation of maternal SARS-CoV-2 antibodies detected in banked newborn dried blood spots (DBS). We obtained seropositive results for 2890 newborn DBS from cohorts in 2020 and 2021 using Enable Bioscience's Antibody Detection by Agglutination-PCR (ADAP) assay for SARS-CoV-2 antibodies. To infer maternal infection, we linked 312 women with a known laboratory-confirmed COVID-19 episode with their newborn's DBS SARS-CoV02 antibody result. Among 2890 newborns, we detected 453 (15.7%) with SARS-CoV-2 antibodies in their DBS. Monthly snapshot statewide seroprevalence among neonates was 12.2% (95% CI 10.3-14.1%,

Identifiants

pubmed: 37606480
pii: ijns9030043
doi: 10.3390/ijns9030043
pmc: PMC10443380
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Stanley Sciortino (S)

Genetic Disease Screening Program, California Department of Public Health, Richmond, CA 94804, USA.

Steve Graham (S)

Genetic Disease Screening Program, California Department of Public Health, Richmond, CA 94804, USA.

Toki Fillman (T)

Genetic Disease Screening Program, California Department of Public Health, Richmond, CA 94804, USA.

Hari Kandasamy (H)

Genetic Disease Screening Program, California Department of Public Health, Richmond, CA 94804, USA.

Robin Cooley (R)

Genetic Disease Screening Program, California Department of Public Health, Richmond, CA 94804, USA.

Carl Hanson (C)

Viral and Rickettsial Disease Laboratory, California Department of Public Health, Richmond, CA 94804, USA.

Valorie Eckert (V)

Genetic Disease Screening Program, California Department of Public Health, Richmond, CA 94804, USA.

Hao Tang (H)

Genetic Disease Screening Program, California Department of Public Health, Richmond, CA 94804, USA.

Juan Yang (J)

Genetic Disease Screening Program, California Department of Public Health, Richmond, CA 94804, USA.

David Seftel (D)

Enable Biosciences, South San Francisco, CA 94080, USA.

Cheng-Ting Tsai (CT)

Enable Biosciences, South San Francisco, CA 94080, USA.

Peter Robinson (P)

Enable Biosciences, South San Francisco, CA 94080, USA.

Classifications MeSH