Senescence of bone marrow mesenchymal stem cells in Wistar male rats receiving normal chow/high-calorie diets with/without vitamin D.
Cell senescence
High-calorie diet
Mesenchymal stem cells
Vitamin D
senescence-associated beta-galactosidase
Journal
Biogerontology
ISSN: 1573-6768
Titre abrégé: Biogerontology
Pays: Netherlands
ID NLM: 100930043
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
04
05
2023
accepted:
23
06
2023
medline:
5
9
2023
pubmed:
22
8
2023
entrez:
22
8
2023
Statut:
ppublish
Résumé
Bone marrow mesenchymal stem cells (BM-MSCs) have a momentous function in the composition of the bone marrow microenvironment because of their many valuable properties and abilities, such as immunomodulation and hematopoiesis. The features and actions of MSCs are influenced by senescence, which may be affected by various factors such as nutritional/micronutrients status, e.g., vitamin D. This study aimed to examine the effects of a high-calorie diet (HCD) with/without vitamin D on BM-MSCs senescence. In the first phase, 48 middle-aged rats were fed a normal chow diet (NCD, n = 24) and an HCD (n = 24) for 26 weeks. Afterward, the rats in each group were randomly divided into three equal subgroups. Immediately, eight-rat from each diet group were sacrificed to assess the HCD effects on the first phase measurements. In the second phase, the remaining 4 groups of rats were fed either NCD or HCD with (6 IU/g) or without vitamin D (standard intake: 1 IU/g); in other words, in this phase, the animals were fed (a) NCD, (b) NCD plus vitamin D, (c) HCD, and (d) HCD plus vitamin D for 4 months. BM-MSCs were isolated and evaluated for P16
Identifiants
pubmed: 37606875
doi: 10.1007/s10522-023-10048-9
pii: 10.1007/s10522-023-10048-9
doi:
Substances chimiques
Vitamin D
1406-16-2
Cyclin-Dependent Kinase Inhibitor p16
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
801-812Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature B.V.
Références
Acar MB, Ayaz-Güner S, Di Bernardo G, Murat A, Peluso G, Özcan S, Galderisi U (2020) Obesity induced by high-fat diet is associated with critical changes in biological and molecular functions of mesenchymal stromal cells present in visceral adipose tissue. Aging 12:24894
pubmed: 33361524
pmcid: 7803587
Al-Azab M, Safi M, Idiiatullina E, Al-Shaebi F, Mohamed YZ (2022) Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting. Cell Mol Biol Lett 27:1–40
Alessio N, Acar MB, Demirsoy IH, Squillaro T, Siniscalco D, Bernardo GD, Peluso G, Özcan S, Galderisi U (2020a) Obesity is associated with senescence of mesenchymal stromal cells derived from bone marrow, subcutaneous and visceral fat of young mice. Aging (Albany NY). 12(13):12609–12621. https://doi.org/10.18632/aging.103606
doi: 10.18632/aging.103606
pubmed: 32634118
Alessio N, Acar MB, Demirsoy IH, Squillaro T, Siniscalco D, Gianfranco U, Peluso G, Galderisi U (2020b) Obesity is associated with senescence of mesenchymal stromal cells derived from bone marrow, subcutaneous and visceral fat of young mice. Aging 12:12609
pubmed: 32634118
pmcid: 7377882
Arif M, Khan MK, Riaz S, Nazir A, Maan AA, Amin U, Saeed F, Afzaal M (2022) Role of fruits in aging and age-related disorders. Exp Gerontol. https://doi.org/10.1016/j.exger.2022.111763
doi: 10.1016/j.exger.2022.111763
pubmed: 35248667
Beane OS, Vera C, Fonseca LL, Cooper G, Koren, Eric MD (2014) Impact of aging on the regenerative properties of bone marrow-, muscle-, and adipose-derived mesenchymal stem/stromal cells. PLoS ONE 9:e115963
pubmed: 25541697
pmcid: 4277426
Bi J, Li Q, Yang Z, Cai L, Lv T, Yang X, Liu L, Yan L, Wang Q, Fu X, Xiao R (2021) CXCL2 impairs functions of bone marrow mesenchymal stem cells and can serve as a serum marker in high-fat diet-fed rats. Front Cell Dev Biol. https://doi.org/10.3389/fcell.2021.687942
doi: 10.3389/fcell.2021.687942
pubmed: 35096831
pmcid: 8733823
Borodkina AV, Shatrova AN, Nikolsky NN, Burova EB (2016) The role of p38 MAP-kinase in stress-induced senescence of human endometrium-derived mesenchymal stem cells. Cell and Tissue Biology 10:365–371
Borojević A, Jauković A, Kukolj T, Mojsilović S, Obradović H, Trivanović D, Živanović M, Zečević Ž, Simić M, Gobeljić B (2022) Vitamin D3 stimulates proliferation capacity, expression of pluripotency markers, and osteogenesis of human bone marrow mesenchymal stromal/stem cells, partly through sirt1 signaling. Biomolecules 12:323
pubmed: 35204824
pmcid: 8868595
Chen L, Yang R, Qiao W, Zhang W, Chen J, Mao L, Goltzman D, Miao D (2019) 1,25-Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2‐antioxidant signaling and inactivation of p16/p53‐senescence signaling. Aging Cell 18:e12951
pubmed: 30907059
pmcid: 6516172
Chen L, Holder R, Porter C, and Zubair Shah (2021) Vitamin D3 attenuates doxorubicin-induced senescence of human aortic endothelial cells by upregulation of IL-10 via the pAMPKα/Sirt1/Foxo3a signaling pathway. PLoS ONE 16:e0252816
pubmed: 34101754
pmcid: 8186764
Chen H, Liu O, Chen S, Yueying Zhou (2022) Aging and mesenchymal stem cells: therapeutic opportunities and challenges in the older group. Gerontology 68:339–52
pubmed: 34161948
Chen J, Zhang J, Li J, Qin R, Lu N, Goltzman D, Miao D, Yang R (2023) 1, 25-Dihydroxyvitamin D Deficiency accelerates aging-related osteoarthritis via downregulation of Sirt1 in mice. Int J Biol Sci 19:610–624
pubmed: 36632467
pmcid: 9830508
Conley SM, LaTonya J, Hickson TA, Kellogg T, McKenzie, Julie K, Heimbach T, Taner H, Tang KL, Jordan IM, Saadiq, John RW (2020) Human obesity induces dysfunction and early senescence in adipose tissue-derived mesenchymal stromal/stem cells. Front Cell Dev Biology 8:197
Cortez M, Carmo LS, Rogero MM, Borelli P, Ricardo Ambrósio F (2013) A high-fat diet increases IL-1, IL-6, and TNF-α production by increasing NF-κB and attenuating PPAR-γ expression in bone marrow mesenchymal stem cells. Inflammation 36:379–86
pubmed: 23079940
da Silva S, Vargas M, Renovato-Martins C, Ribeiro‐Pereira M, Citelli, Barja‐Fidalgo C (2016) Obesity modifies bone marrow microenvironment and directs bone marrow mesenchymal cells to adipogenesis. Obesity 24:2522–2532
pubmed: 27753270
Dorronsoro A, Santiago FE, Grassi D, Zhang T, Lai RC, McGowan SJ, Angelini L, Lavasani M, Carbo L, Lu A (2021) Mesenchymal stem cell-derived extracellular vesicles reduce senescence and extend health span in mouse models of aging. Aging Cell 20:13337
Faraonio R (2022) Oxidative stress and cell senescence process. Antioxidants. 11(9):1718. https://doi.org/10.3390/antiox11091718
doi: 10.3390/antiox11091718
pubmed: 36139791
pmcid: 9495308
Festing MFW (2006) Design and statistical methods in studies using animal models of development. ILAR J 47:5–14
pubmed: 16391426
Freund A, Patil CK, Campisi J (2011) p38MAPK is a novel DNA damage response-independent regulator of the senescence‐associated secretory phenotype. EMBO J 30:1536–1548
pubmed: 21399611
pmcid: 3102277
Gao G, Li W, Fan C, Liang R, Wei C, Chen X, Yang Y, Zhong Y, Shao Y, Kong Y (2021) Mesenchymal stem cells: ideal seeds for treating diseases. Hum Cell 34:1585–600
pubmed: 34272720
pmcid: 8284686
Gerdes EO, Wissler Y, Zhu BM, Weigand U, Tripathi TC, Burns T, Tchkonia, James LK (2020) Cellular senescence in aging and age-related diseases: implications for neurodegenerative diseases. Int Rev Neurobiol 155:203–234
He S, Sharpless NE (2017) Senescence in health and disease. Cell 169(6):1000–1011. https://doi.org/10.1016/j.cell.2017.05.015
doi: 10.1016/j.cell.2017.05.015
pubmed: 28575665
pmcid: 5643029
Jeong S-G, Cho G-W (2015) Endogenous ROS levels are increased in replicative senescence in human bone marrow mesenchymal stromal cells. Biochem Biophys Res Commun 460:971–76
pubmed: 25839657
Kim S, Rin K, Jiang M, Ogrodnik X, Chen X-Y, Zhu H, Lohmeier L, Ahmed H, Tang T, Tchkonia, LaTonya JH (2019) Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin. Translational Res 213:112–123
Klotz B, Mentrup B, Regensburger M, Zeck S, Schneidereit J, Schupp N, Linden C, Merz C, Ebert R, Jakob F (2012) 1, 25-dihydroxyvitamin D3 treatment delays cellular aging in human mesenchymal stem cells while maintaining their multipotent capacity. PLoS One 7:e29959
pubmed: 22242193
pmcid: 3252365
Li J, Karim MA, Che H, Geng Q, Dengshun, Miao (2020) Deletion of p16 prevents estrogen deficiency-induced osteoporosis by inhibiting oxidative stress and osteocyte senescence. Am J Translational Res 12:672
Li W, Che Xu, Chen X, Zhou M, Luo X, Tao, Liu (2021a) Study of calcitriol anti-aging effects on human natural killer cells in vitro. Bioengineered 12:6844–6854
pubmed: 34546851
pmcid: 8806577
Li Y, Lu L, Xie Y, Chen X, Tian L, Liang Y, Li H, Zhang J, Liu Y, and Xijie Yu (2021b) Interleukin-6 knockout inhibits senescence of bone mesenchymal stem cells in high-fat diet-induced bone loss. Front Endocrinol 11:622950
Li X, Wang X, Zhang C, Wang J, Wang S, Lei Hu (2022) Dysfunction of metabolic activity of bone marrow mesenchymal stem cells in aged mice. Cell Prolif 55:e13191
pubmed: 35088483
pmcid: 8891618
Liu J, Gao J, Liang Z, Gao C, Niu Q, Wu F, Zhang L (2022) Mesenchymal stem cells and their microenvironment. Stem Cell Res Ther 13:429
pubmed: 35987711
pmcid: 9391632
Luque-Campos N, Bustamante-Barrientos FA, Pradenas C, García C, Araya MJ, Bohaud C, Contreras-López R, Elizondo-Vega R, Djouad F, Luz-Crawford P (2021) The Macrophage response is driven by mesenchymal stem cell-mediated metabolic reprogramming. Front Immunol 12:624746
pubmed: 34149687
pmcid: 8213396
Marampon F, Gravina GL, Festuccia C, Popov VM, Colapietro EA, Sanita P, Musio D, De Felice F, Lenzi A, Jannini EA (2016) Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SirT1 axis. J Endocrinol Investig 39:411–422
Minamino T, Orimo M, Shimizu I, Kunieda T, Yokoyama M, Ito T, Akira NA, Nabetani YO, Matsubara H (2009) A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med 15:1082–87
pubmed: 19718037
Molofsky AV, Pardal R, Iwashita T, Park I-K, Clarke MF, Sean JM (2003) Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425:962–67
pubmed: 14574365
pmcid: 2614897
Neri S, Rosa Maria B (2020) Molecular mechanisms contributing to mesenchymal stromal cell aging. Biomolecules 10:340
pubmed: 32098040
pmcid: 7072652
Omidifar N, Mousavi SM, Hashemi SA, Gholami A, Shokripour M, Sohrabi Zahra (2021) ‘Trends in natural nutrients for oxidative stresscell senescence. Oxid Med Cell Longev. 2021:7501424. https://doi.org/10.1155/2021/7501424
doi: 10.1155/2021/7501424
pubmed: 34306314
pmcid: 8270688
Pini M, Czibik G, Sawaki D, Mezdari Z, Braud L, Delmont T, Mercedes R, Martel C, Buron N, Marcelin G (2021) Adipose tissue senescence is mediated by increased ATP content after a short-term high-fat diet exposure. Aging Cell 20:e13421
pubmed: 34278707
pmcid: 8373332
Qiao W, Yu S, Sun H, Chen L, Wang R, Wu X, Goltzman D, Miao D (2020) 1, 25-Dihydroxyvitamin D insufficiency accelerates age-related bone loss by increasing oxidative stress and cell senescence. Am J Translational Res 12:507
Samsonraj RM, Raghunath M, Nurcombe V, Hui JH, Andre J, van Wijnen, Simon MC (2017) Concise review: multifaceted characterization of human mesenchymal stem cells for use in regenerative medicine. Stem cells translational medicine 6:2173–2185
pubmed: 29076267
pmcid: 5702523
Shakeri H, Lemmens K, Andreas B, Gevaert, Guido RY, De Meyer, Vincent FMS (2018) Cellular senescence links aging and diabetes in cardiovascular disease. Am J Physiol Heart Circ Physiol 315:H448–H62
pubmed: 29750567
Sun H, Qiao W, Cui M, Yang C, Wang R, Goltzman D, Jin J, and Dengshun Miao (2020) The polycomb protein Bmi1 plays a crucial role in the Prevention of 1, 25 (OH) 2D Deficiency-Induced Bone loss. J Bone Miner Res 35:583–595
pubmed: 31725940
Teresa Rubio-Tomás, Rueda-Robles Ascensión, Plaza-Díaz Julio, Álvarez-Mercado Ana I (2022) Nutrition and cellular senescence in obesity-related disorders. J Nutr Biochem 99:108861
Woods K, and Borhane Guezguez (2021) Dynamic changes of the bone marrow niche: mesenchymal stromal cells and their progeny during aging and leukemia. Front Cell Dev Biology 9:714716
Xiao Y, Zhu Q, Liu X, Jiang M, Hao H, Zhu H, Peter J, Cowan X, He Q, Liu, Zhou S (2020) High-fat diet selectively decreases bone marrow lin–/CD117 + cell population in aging mice through increased ROS production. J Tissue Eng Regen Med 14:884–892
pubmed: 32337800
pmcid: 7372732
Xie C, Jin J, Lv X, Tao J, Wang R, and Dengshun Miao (2015) Anti-aging effect of transplanted amniotic membrane mesenchymal stem cells in a premature aging model of Bmi-1 deficiency. Sci Rep 5:13975
pubmed: 26370922
pmcid: 4570627
Yang R, Chen J, Zhang J, Qin R, Wang R, Qiu Y, Mao Z, Goltzman D, Miao D (2020) 1, 25-Dihydroxyvitamin D protects against age‐related osteoporosis by a novel VDR‐Ezh2‐p16 signal axis. Aging Cell 19:e13095
pubmed: 31880094
Yin M, Zhang Y, Haibo Yu, and, Li X (2021) Role of hyperglycemia in the senescence of mesenchymal stem cells. Front Cell Dev Biology 9:665412
Zhang H-W, Ding J, Jin Jian‐Liang, Guo J, Liu Jing‐Ning, Karaplis A, Goltzman D, Miao D (2010) Defects in mesenchymal stem cell self‐renewal and cell fate determination lead to an osteopenic phenotype in Bmi‐1 null mice. J Bone Miner Res 25:640–652
pubmed: 19653817
Zhang X, Xu GB, Zhou D, Yuan-Xiang P (2018) High-fat diet modifies expression of hepatic cellular senescence gene p16 (INK4a) through chromatin modifications in adult male rats. Genes & nutrition 13:1–12
Zhang Y, Liao S, Fu Q, Hamrick M (2021) Mesenchymal stem cell senescence and rejuvenation. Front Cell Develop Biol. 9:772476. https://doi.org/10.3389/fcell.2021.772476
doi: 10.3389/fcell.2021.772476