Disruption of Iron Homeostasis to Induce Ferroptosis with Albumin-Encapsulated Pt(IV) Nanodrug for the Treatment of Non-Small Cell Lung Cancer.
HSA@Pt(IV)
ferroptosis
ionome
nanodrug
platinum drug
Journal
Small (Weinheim an der Bergstrasse, Germany)
ISSN: 1613-6829
Titre abrégé: Small
Pays: Germany
ID NLM: 101235338
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
revised:
27
06
2023
received:
30
10
2022
pubmed:
22
8
2023
medline:
22
8
2023
entrez:
22
8
2023
Statut:
ppublish
Résumé
Non-small cell lung cancer (NSCLC) is the most common pathological type of lung cancer , accounting for approximately 85% of lung cancers. For more than 40 years, platinum (Pt)-based drugs are still one of the most widely used anticancer drugs even in the era of precision medicine and immunotherapy. However, the clinical limitations of Pt-based drugs, such as serious side effects and drug resistance, have not been well solved. This study constructs a new albumin-encapsulated Pt(IV) nanodrug (HSA@Pt(IV)) based on the Pt(IV) drug and nanodelivery system. The characterization of nanodrug and biological experiments demonstrate its excellent drug delivery and antitumor effects. The multi-omics analysis of the transcriptome and the ionome reveals that nanodrug can activate ferroptosis by affecting intracellular iron homeostasis in NSCLC. This study provides experimental evidence to suggest the potential of HSA@Pt(IV) as a nanodrug with clinical application.
Identifiants
pubmed: 37606911
doi: 10.1002/smll.202206688
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2206688Subventions
Organisme : Health Commission of Hunan Province
ID : 202213014985
Organisme : National Natural Science Foundation of China
ID : 82073943
Organisme : Hunan Cancer Hospital Climb Plan
ID : YF2020011
Organisme : Zhejiang Provincial Natural Science Foundation of China
ID : LZ23C070004
Informations de copyright
© 2023 The Authors. Small published by Wiley-VCH GmbH.
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