Hybrid Vesicles Enable Mechano-Responsive Hydrogel Degradation.
Block Copolymers
Functional Material
Stimuli-Responsive Hydrogel
Stress-Induced Degradation
Vesicles
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
09 Oct 2023
09 Oct 2023
Historique:
received:
15
06
2023
pmc-release:
09
10
2024
medline:
22
8
2023
pubmed:
22
8
2023
entrez:
22
8
2023
Statut:
ppublish
Résumé
Stimuli-responsive hydrogels are intriguing biomimetic materials. Previous efforts to develop mechano-responsive hydrogels have mostly relied on chemical modifications of the hydrogel structures. Here, we present a simple, generalizable strategy that confers mechano-responsive behavior on hydrogels. Our approach involves embedding hybrid vesicles, composed of phospholipids and amphiphilic block copolymers, within the hydrogel matrix to act as signal transducers. Under mechanical stress, these vesicles undergo deformation and rupture, releasing encapsulated compounds that can control the hydrogel network. To demonstrate this concept, we embedded vesicles containing ethylene glycol tetraacetic acid (EGTA), a calcium chelator, into a calcium-crosslinked alginate hydrogel. When compressed, the released EGTA sequesters calcium ions and degrades the hydrogel. This study provides a novel method for engineering mechano-responsive hydrogels that may be useful in various biomedical applications.
Identifiants
pubmed: 37607024
doi: 10.1002/anie.202308509
pmc: PMC10600738
mid: NIHMS1926988
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202308509Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB030031
Pays : United States
Organisme : NIAMS NIH HHS
ID : R21 AR080363
Pays : United States
Organisme : NIH HHS
ID : R01 EB030031
Pays : United States
Organisme : NIH HHS
ID : R21 AR080363
Pays : United States
Informations de copyright
© 2023 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.
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