A new class of protein sensor links spirochete pleomorphism, persistence, and chemotaxis.
biofilms
chemotaxis
cryoEM
protein sensor
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
21 Aug 2023
21 Aug 2023
Historique:
medline:
22
8
2023
pubmed:
22
8
2023
entrez:
22
8
2023
Statut:
aheadofprint
Résumé
Pathogenic spirochetes can alter their morphologies and behaviors to infect and survive within their hosts. Previous reports demonstrate that the formation of the so-called "round bodies" and biofilms, and chemotaxis are involved in spirochete pathogenesis. Here, we report a direct link between these cellular states that involve a new class of protein sensor with hitherto unclear function. Using cryo-electron microscopy, genetics, behavioral assays, and molecular modeling, we demonstrate that spirochetes regulate these behaviors in response to the small molecule
Identifiants
pubmed: 37607060
doi: 10.1128/mbio.01598-23
pmc: PMC10653840
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0159823Subventions
Organisme : NIAID NIH HHS
ID : R01 AI078958
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI148844
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE023080
Pays : United States
Références
PLoS Biol. 2019 Aug 29;17(8):e3000395
pubmed: 31465435
Nat Methods. 2022 Jun;19(6):679-682
pubmed: 35637307
Med Hypotheses. 2006;67(3):592-600
pubmed: 16675154
J Bacteriol. 1994 May;176(9):2727-35
pubmed: 8169223
Appl Microbiol Biotechnol. 2022 Oct;106(19-20):6365-6381
pubmed: 36089638
J Dent Res. 1984 Mar;63(3):412-21
pubmed: 6583243
Pathogens. 2019 Dec 16;8(4):
pubmed: 31888245
Sci Signal. 2020 Nov 10;13(657):
pubmed: 33172954
J Bacteriol. 1994 Oct;176(19):6088-99
pubmed: 7928971
PLoS One. 2013 Aug 26;8(8):e71727
pubmed: 23990979
Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):123-7
pubmed: 11742065
J Microbiol Methods. 2010 Feb;80(2):123-8
pubmed: 19932718
Nat Commun. 2020 Nov 13;11(1):5763
pubmed: 33188180
J Bacteriol. 2011 May;193(10):2652-6
pubmed: 21441520
Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3335-40
pubmed: 26951681
Microbiology (Reading). 2004 Jul;150(Pt 7):2401-2407
pubmed: 15256581
J Exp Med. 1950 Sep;92(3):239-46
pubmed: 15436933
Parasit Vectors. 2019 May 16;12(1):237
pubmed: 31097026
Nat Struct Biol. 1998 Jun;5(6):446-50
pubmed: 9628482
Nucleic Acids Res. 2020 Jan 8;48(D1):D459-D464
pubmed: 31754718
Front Cell Infect Microbiol. 2019 Aug 14;9:298
pubmed: 31475121
Nucleic Acids Res. 2013 Jul;41(12):e121
pubmed: 23598997
Structure. 1997 Apr 15;5(4):545-58
pubmed: 9115443
J Antimicrob Chemother. 2009 Jun;63(6):1163-72
pubmed: 19376840
PLoS Comput Biol. 2013;9(11):e1003337
pubmed: 24244143
J Biol Chem. 2013 Jun 28;288(26):18987-99
pubmed: 23677992
Trends Biochem Sci. 2008 Jan;33(1):9-19
pubmed: 18165013
Infect Immun. 1986 Jul;53(1):213-20
pubmed: 3013780
Anaerobe. 2021 Jun;69:102345
pubmed: 33596466
Front Microbiol. 2016 May 23;7:743
pubmed: 27242757
mBio. 2019 Jul 2;10(4):
pubmed: 31266867
Sci Signal. 2010 Jun 29;3(128):ra50
pubmed: 20587806
J Mol Biol. 2010 Nov 5;403(4):546-61
pubmed: 20850455
Annu Rev Microbiol. 2011;65:261-86
pubmed: 21663441
Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):10412-7
pubmed: 27573843
Nature. 2021 Aug;596(7873):583-589
pubmed: 34265844
Wien Klin Wochenschr. 2020 Sep;132(17-18):493-498
pubmed: 32215721
Elife. 2015 Nov 19;4:
pubmed: 26583751
Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2118227119
pubmed: 35238645
mBio. 2021 Jun 29;12(3):e0017321
pubmed: 34154415
Elife. 2014 Mar 25;3:e02151
pubmed: 24668172
Infect Immun. 2016 Dec 29;85(1):
pubmed: 27799336
J Mol Neurosci. 2021 Jul;71(7):1506-1514
pubmed: 33763842
Mol Microbiol. 2012 Aug;85(4):782-94
pubmed: 22780444
Arch Microbiol. 1993;160(3):206-13
pubmed: 8215797
J Bacteriol. 2013 Sep;195(17):3897-905
pubmed: 23794624
Infection. 1998 May-Jun;26(3):144-50
pubmed: 9646104
Microbiology (Reading). 2015 Mar;161(Pt 3):516-27
pubmed: 25564498
Bioorg Chem. 2011 Dec;39(5-6):161-70
pubmed: 21762947
mBio. 2019 Feb 26;10(1):
pubmed: 30808696
PLoS One. 2015 Mar 25;10(3):e0117207
pubmed: 25806811
FEMS Microbiol Rev. 2018 Jul 1;42(4):448-461
pubmed: 29672765
J Struct Biol. 2009 Dec;168(3):378-87
pubmed: 19732834
Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):14955-14960
pubmed: 31270241
Infect Immun. 2016 May 24;84(6):1743-1752
pubmed: 27021244
Mol Microbiol. 2011 Jan;79(1):7-20
pubmed: 21166890
PLoS Pathog. 2012 Feb;8(2):e1002532
pubmed: 22359504
APMIS. 1998 Dec;106(12):1131-41
pubmed: 10052721
Microbiol Immunol. 1982;26(3):191-8
pubmed: 7109978
Infect Immun. 2001 Oct;69(10):6276-83
pubmed: 11553571
Appl Environ Microbiol. 2015 Dec 18;82(4):1346-52
pubmed: 26682856
Front Cell Infect Microbiol. 2019 Dec 18;9:432
pubmed: 31921707
J Struct Biol. 2016 Dec;196(3):364-374
pubmed: 27544050
Annu Rev Biophys. 2017 May 22;46:1-21
pubmed: 28301773
Commun Biol. 2020 Jan 10;3(1):24
pubmed: 31925330
J Neuroinflammation. 2011 Aug 04;8:90
pubmed: 21816039
Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3766-71
pubmed: 22355139
Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):E791-800
pubmed: 26811460
Biochim Biophys Acta Biomembr. 2020 Jan 1;1862(1):183030
pubmed: 31374212
PLoS Pathog. 2020 Oct 1;16(10):e1008881
pubmed: 33002094
Microbiology (Reading). 2000 Jan;146 ( Pt 1):119-127
pubmed: 10658658
FEMS Microbiol Lett. 2005 Sep 15;250(2):271-7
pubmed: 16085371
Infect Immun. 2012 Jul;80(7):2485-92
pubmed: 22508862
J Struct Biol. 1997 Dec;120(3):343-52
pubmed: 9441937
Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9162-70
pubmed: 27506799