Oral microbiome and preterm birth.
16S rDNA
16S rRNA gene
microbiome
oral microbiome
pregnancy
preterm delivery
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2023
2023
Historique:
received:
02
03
2023
accepted:
25
07
2023
medline:
23
8
2023
pubmed:
23
8
2023
entrez:
23
8
2023
Statut:
epublish
Résumé
The etiology of preterm birth (PTB) is heterogeneous and not yet well known. Maternal periodontal disease has been investigated for decades and is a known risk factor for adverse pregnancy outcomes. However, no particular bacterial species or higher taxonomic order has been found as causative of PTB, leading to studies of the whole oral microbiome. In order to determine if and how the composition of the oral microbiome is associated with PTB, we performed a large case-control study including women with term (TB) and PTB. We compared oral microbiomes in PTB to TB, to examine differences in the microbial richness, diversity, and differential abundance of specific taxa. We obtained oral swab samples from 152 Caucasian pregnant women who were classified as either PTB (≤36 6/7 weeks, The dominant microorganisms at the phylum level in all pregnant women regardless of birth week outcomes as belonging to We identified the genera
Sections du résumé
Background
UNASSIGNED
The etiology of preterm birth (PTB) is heterogeneous and not yet well known. Maternal periodontal disease has been investigated for decades and is a known risk factor for adverse pregnancy outcomes. However, no particular bacterial species or higher taxonomic order has been found as causative of PTB, leading to studies of the whole oral microbiome. In order to determine if and how the composition of the oral microbiome is associated with PTB, we performed a large case-control study including women with term (TB) and PTB.
Methods
UNASSIGNED
We compared oral microbiomes in PTB to TB, to examine differences in the microbial richness, diversity, and differential abundance of specific taxa. We obtained oral swab samples from 152 Caucasian pregnant women who were classified as either PTB (≤36 6/7 weeks,
Results
UNASSIGNED
The dominant microorganisms at the phylum level in all pregnant women regardless of birth week outcomes as belonging to
Conclusion
UNASSIGNED
We identified the genera
Identifiants
pubmed: 37608830
doi: 10.3389/fmed.2023.1177990
pmc: PMC10441245
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1177990Informations de copyright
Copyright © 2023 Vidmar Šimic, Maver, Zimani, Hočevar, Peterlin, Kovanda and Premru-Sršen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest.
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