Mechanisms of Pathogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant R278C

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
13 Aug 2023
Historique:
pubmed: 23 8 2023
medline: 23 8 2023
entrez: 23 8 2023
Statut: epublish

Résumé

Hypertrophic cardiomyopathy (HCM) is one of the most common heritable cardiovascular diseases and variants of

Identifiants

DOI: 10.1101/2023.06.06.542948 PMID: 37609317 PMC: PMC10441323
pubmed: 37609317
doi: 10.1101/2023.06.06.542948
pmc: PMC10441323
pii:
doi:

Types de publication

Preprint

Langues

eng

Déclaration de conflit d'intérêts

Competing interests. R.J.S. is a member of the Scientific Advisor Board of Cytokinetics, Inc., and a consultant to Myokardia/Bristol- Myers-Squibb.

Auteurs

Sanam Shafaattalab (S)

Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.
Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.

Alison Y Li (AY)

Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.
Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.

Farah Jayousi (F)

Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.
Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.

Yasaman Maaref (Y)

Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.
Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.

Saif Dababneh (S)

Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.
Department of Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.

Homa Hamledari (H)

Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.
Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.

Dina Hosseini Baygi (DH)

Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.
Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.

Tiffany Barszczewski (T)

Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.
Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.

Balwinder Ruprai (B)

Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.
Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.

Shayan Jannati (S)

Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.
Mechanical Engineering, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.

Raghu Nagalingam (R)

Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.
Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.

Austin M Cool (AM)

Department of Chemistry and Biochemistry, Ohio State University, Columbus, OH, USA.

Paulina Langa (P)

Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA.

Mu Chiao (M)

Mechanical Engineering, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.

Thomas Roston (T)

Division of Cardiology and Centre for Cardiovascular Innovation, The University of British Columbia 1081 Burrard Street, Level 4 Cardiology Vancouver, BC, V6Z 1Y6, Canada.

R John Solaro (RJ)

Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA.

Shubhayan Sanatani (S)

Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.

Christopher Toepfer (C)

University of Oxford, Oxford, UK.

Steffen Lindert (S)

Mechanical Engineering, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.

Philipp Lange (P)

Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC.
Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.

Glen F Tibbits (GF)

Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.
Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.
Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.
School of Biomedical Engineering, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.

Classifications MeSH