Miniature mass spectrometers and their potential for clinical point-of-care analysis.
clinical applications
instrumentation
miniature mass spectrometer
point-of-care analysis
Journal
Mass spectrometry reviews
ISSN: 1098-2787
Titre abrégé: Mass Spectrom Rev
Pays: United States
ID NLM: 8219702
Informations de publication
Date de publication:
23 Aug 2023
23 Aug 2023
Historique:
revised:
04
08
2023
received:
27
05
2023
accepted:
11
08
2023
medline:
23
8
2023
pubmed:
23
8
2023
entrez:
23
8
2023
Statut:
aheadofprint
Résumé
Mass spectrometry (MS) has become a powerful technique for clinical applications with high sensitivity and specificity. Different from conventional MS diagnosis in laboratory, point-of-care (POC) analyses in clinics require mass spectrometers and analytical procedures to be friendly for novice users and applicable for on-site clinical diagnosis. The recent decades have seen the progress in the development of miniature mass spectrometers, providing a promising solution for clinical POC applications. In this review, we report recent advances of miniature mass spectrometers and their exploration in clinical applications, mainly including the rapid analysis of illegal drugs, on-site monitoring of therapeutic drugs, and detection of biomarkers. With improved analytical performance, miniature mass spectrometers are also expected to apply to more and more clinical applications. Some promising POC analyses that can be performed by miniature mass spectrometers in the future are discussed. Lastly, we also provide our perspectives on the challenges in technical development of miniature mass spectrometers for clinical POC analysis.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Beijing Institute of Technology Research Fund Program for Young Scholars
ID : XSQD-202123004
Organisme : NNSF
ID : 22004007
Organisme : Young Elite Scientist Sponsorship Program of Beijing Association for Science and Technology
ID : 2022-2024
Organisme : Young Elite Scientist Sponsorship Program of Beijing Association for Science and Technology
ID : BYESS2022134
Informations de copyright
© 2023 John Wiley & Sons Ltd.
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