Trabecular Bone Score in Assessing Bone Mineralization Status in Children with End- Stage Renal Disease: A Promising Tool.
Bone mineral density
Chronic kidney disease
DXA
Hemodialysis
Trabecular bone score
Journal
European journal of pediatrics
ISSN: 1432-1076
Titre abrégé: Eur J Pediatr
Pays: Germany
ID NLM: 7603873
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
14
06
2023
accepted:
09
08
2023
revised:
25
07
2023
medline:
13
11
2023
pubmed:
23
8
2023
entrez:
23
8
2023
Statut:
ppublish
Résumé
Areal-bone mineral density (aBMD) of lumbar-spine dual energy X-ray absorptiometry (DXA) scan is the most frequently used tool in evaluating BMD in pediatric patients, however its size dependency have significant impact on measurements accuracy in children with chronic kidney disease (CKD). This study aimed to evaluate the usefulness of trabecular bone score (TBS) computed during lumbar-spine DXA scan in assessing bone status in children on maintenance hemodialysis (HD). Ninety-three children on HD (aged 9-18 years) were subjected to lumbar-spine DXA-scan to obtain aBMD (g/cm TBS is significantly reduced in children on maintenance HD and is associated with increased fracture incidence. TBS has shown to be a promising tool in assessing bone quality (trabecular microarchitecture) in children with CKD being not size-dependent as is a-BMD, for further evaluation of its potential role in therapeutic and follow-up decisions. • In children with CKD, bone demineralization starts as early as CKD stage 2, so assessment of bone health is mandatory for follow up and therapeutic decisions. • aBMD of lumbar-spine DXA scan is the most used tool in evaluating BMD in pediatric patients, however its size dependency have significant impact on measurements made in children with CKD. • TBS is significantly reduced in children on maintenance HD and associated with increased fracture incidence. • TBS has shown to be a promising tool in assessing bone quality (trabecular microarchitecture) in children with CKD being not size-dependent as is a-BMD.
Identifiants
pubmed: 37610434
doi: 10.1007/s00431-023-05157-z
pii: 10.1007/s00431-023-05157-z
pmc: PMC10640476
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4957-4967Informations de copyright
© 2023. The Author(s).
Références
J Clin Densitom. 2014 Apr-Jun;17(2):219-24
pubmed: 24657108
J Bone Miner Res. 2022 Apr;37(4):776-785
pubmed: 35118727
Acta Paediatr. 2009 Feb;98(2):367-73
pubmed: 18976351
J Clin Densitom. 2014 Apr-Jun;17(2):225-42
pubmed: 24690232
Ann Intern Med. 2018 Mar 20;168(6):422-430
pubmed: 29459980
Osteoporos Int. 2016 Aug;27(8):2467-75
pubmed: 26952009
Am J Kidney Dis. 2015 Nov;66(5):884-930
pubmed: 26498416
Pediatr Nephrol. 2007 Jan;22(1):121-7
pubmed: 16977474
Best Pract Res Clin Endocrinol Metab. 2022 Mar;36(2):101616
pubmed: 35125324
BMC Nephrol. 2020 Jul 25;21(1):299
pubmed: 32711466
Pediatr Nephrol. 2007 Oct;22(10):1767-72
pubmed: 17680276
J Bone Miner Res. 2020 Sep;35(9):1685-1694
pubmed: 32395832
Pediatr Nephrol. 2012 Jul;27(7):1139-48
pubmed: 22350304
Osteoporos Int. 2016 Feb;27(2):703-10
pubmed: 26323328
Pediatr Nephrol. 2021 Jul;36(7):1861-1870
pubmed: 33598823
Am J Kidney Dis. 2002 Apr;39(4):843-9
pubmed: 11920352
Semin Nephrol. 2014 Nov;34(6):612-25
pubmed: 25498380
Bone Miner. 1992 Apr;17(1):75-85
pubmed: 1581707
J Clin Endocrinol Metab. 2007 Jun;92(6):2030-2
pubmed: 17554053
Pediatr Nephrol. 2007 Nov;22(11):1815-24
pubmed: 17622566
Arch Osteoporos. 2017 Oct 18;12(1):90
pubmed: 29046970
J Clin Endocrinol Metab. 2001 Feb;86(2):613-8
pubmed: 11158018
Bone. 2017 Nov;104:84-90
pubmed: 27989544
Kidney Int Suppl (2011). 2017 Jul;7(1):1-59
pubmed: 30675420
J Clin Densitom. 2008 Jan-Mar;11(1):29-42
pubmed: 18442751
J Clin Endocrinol Metab. 2015 Sep;100(9):3436-42
pubmed: 26108094
Pediatr Nephrol. 2005 Oct;20(10):1466-72
pubmed: 16047218
Bone. 2018 Nov;116:215-220
pubmed: 30098418
Clin Nutr. 2019 Jun;38(3):1166-1170
pubmed: 29739679
Pediatr Nephrol. 2019 Dec;34(12):2563-2569
pubmed: 31375914
Arch Osteoporos. 2018 Aug 27;13(1):93
pubmed: 30151698
Pediatr Nephrol. 2000 Dec;15(3-4):221-8
pubmed: 11149115
J Clin Densitom. 2021 Apr-Jun;24(2):268-274
pubmed: 33358221
J Bone Miner Res. 2014 Mar;29(3):518-30
pubmed: 24443324
Pediatr Nephrol. 2004 Dec;19(12):1390-3
pubmed: 15517415
Wien Klin Wochenschr. 2022 Jun;134(11-12):442-448
pubmed: 35262788
Eur J Pediatr. 2001 Jun;160(6):359-63
pubmed: 11421415
Am J Kidney Dis. 2009 Mar;53(3 Suppl 2):S11-104
pubmed: 19231749
Arch Osteoporos. 2019 Feb 27;14(1):26
pubmed: 30815747
Clin J Am Soc Nephrol. 2016 Nov 7;11(11):2032-2040
pubmed: 27797885
J Clin Densitom. 2021 Apr-Jun;24(2):243-251
pubmed: 33189561
Arch Dis Child. 1976 Mar;51(3):170-9
pubmed: 952550
Am J Transplant. 2001 Sep;1(3):243-50
pubmed: 12102258
J Pediatr Endocrinol Metab. 2021 Jul 19;34(10):1291-1302
pubmed: 34273916
Kidney Int. 2006 Jun;69(11):1945-53
pubmed: 16641930
Front Med (Lausanne). 2022 Jan 20;8:782837
pubmed: 35127749
Kidney Int. 2017 Dec;92(6):1343-1355
pubmed: 28964571
Osteoporos Int. 2003 Jun;14(4):283-8
pubmed: 12730774
J Clin Endocrinol Metab. 2007 Jun;92(6):2087-99
pubmed: 17311856
J Pediatr. 2005 Jun;146(6):726-31
pubmed: 15973307