Distinguishing subtypes of spinal locomotor neurons to inform circuit function and dysfunction.
Central pattern generator
Interneuron
Locomotion
Rhythm generation
Spinal cord injury
Journal
Current opinion in neurobiology
ISSN: 1873-6882
Titre abrégé: Curr Opin Neurobiol
Pays: England
ID NLM: 9111376
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
10
05
2023
revised:
30
06
2023
accepted:
22
07
2023
pmc-release:
01
10
2024
medline:
11
9
2023
pubmed:
24
8
2023
entrez:
23
8
2023
Statut:
ppublish
Résumé
Locomotion is a complex motor task executed by spinal neurons. Given the diversity of spinal cord neurons, linking neuronal cell type to function is a challenge. Molecular identification of broad spinal interneuronal classes provided a great advance. Recent studies have used other classifiers, including location, electrophysiological properties, and connectivity, in addition to gene profiling, to narrow the acuity with which groups of neurons can be related to specific functions. However, there are also functional populations without a clear identifier, as exemplified by rhythm generating neurons. Other considerations, including experience or plasticity, add a layer of complexity to the definition of functional subpopulations of spinal neurons, but spinal cord injury may provide insight.
Identifiants
pubmed: 37611531
pii: S0959-4388(23)00088-0
doi: 10.1016/j.conb.2023.102763
pmc: PMC10578609
mid: NIHMS1927517
pii:
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
102763Subventions
Organisme : NINDS NIH HHS
ID : R01 NS104194
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS130799
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS118226
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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