Effect of apolipoprotein genotype and educational attainment on cognitive function in autosomal dominant Alzheimer's disease.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
23 08 2023
23 08 2023
Historique:
received:
09
02
2023
accepted:
09
08
2023
medline:
25
8
2023
pubmed:
24
8
2023
entrez:
23
8
2023
Statut:
epublish
Résumé
Autosomal dominant Alzheimer's disease (ADAD) is genetically determined, but variability in age of symptom onset suggests additional factors may influence cognitive trajectories. Although apolipoprotein E (APOE) genotype and educational attainment both influence dementia onset in sporadic AD, evidence for these effects in ADAD is limited. To investigate the effects of APOE and educational attainment on age-related cognitive trajectories in ADAD, we analyzed data from 675 Presenilin-1 E280A mutation carriers and 594 non-carriers. Here we show that age-related cognitive decline is accelerated in ADAD mutation carriers who also have an APOE e4 allele compared to those who do not and delayed in mutation carriers who also have an APOE e2 allele compared to those who do not. Educational attainment is protective and moderates the effect of APOE on cognition. Despite ADAD mutation carriers being genetically determined to develop dementia, age-related cognitive decline may be influenced by other genetic and environmental factors.
Identifiants
pubmed: 37612284
doi: 10.1038/s41467-023-40775-z
pii: 10.1038/s41467-023-40775-z
pmc: PMC10447560
doi:
Substances chimiques
Apolipoproteins
0
Apolipoproteins E
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
5120Subventions
Organisme : NIA NIH HHS
ID : K23 AG062750
Pays : United States
Informations de copyright
© 2023. Springer Nature Limited.
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