Diversity and complexity of cell death: a historical review.
Journal
Experimental & molecular medicine
ISSN: 2092-6413
Titre abrégé: Exp Mol Med
Pays: United States
ID NLM: 9607880
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
23
05
2023
accepted:
11
07
2023
revised:
22
06
2023
medline:
4
9
2023
pubmed:
24
8
2023
entrez:
23
8
2023
Statut:
ppublish
Résumé
Death is the inevitable fate of all living organisms, whether at the individual or cellular level. For a long time, cell death was believed to be an undesirable but unavoidable final outcome of nonfunctioning cells, as inflammation was inevitably triggered in response to damage. However, experimental evidence accumulated over the past few decades has revealed different types of cell death that are genetically programmed to eliminate unnecessary or severely damaged cells that may damage surrounding tissues. Several types of cell death, including apoptosis, necrosis, autophagic cell death, and lysosomal cell death, which are classified as programmed cell death, and pyroptosis, necroptosis, and NETosis, which are classified as inflammatory cell death, have been described over the years. Recently, several novel forms of cell death, namely, mitoptosis, paraptosis, immunogenic cell death, entosis, methuosis, parthanatos, ferroptosis, autosis, alkaliptosis, oxeiptosis, cuproptosis, and erebosis, have been discovered and advanced our understanding of cell death and its complexity. In this review, we provide a historical overview of the discovery and characterization of different forms of cell death and highlight their diversity and complexity. We also briefly discuss the regulatory mechanisms underlying each type of cell death and the implications of cell death in various physiological and pathological contexts. This review provides a comprehensive understanding of different mechanisms of cell death that can be leveraged to develop novel therapeutic strategies for various diseases.
Identifiants
pubmed: 37612413
doi: 10.1038/s12276-023-01078-x
pii: 10.1038/s12276-023-01078-x
pmc: PMC10474147
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1573-1594Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2023. The Author(s).
Références
Nat Rev Mol Cell Biol. 2004 Nov;5(11):897-907
pubmed: 15520809
Front Pharmacol. 2020 Mar 17;11:239
pubmed: 32256352
Cancers (Basel). 2020 Sep 01;12(9):
pubmed: 32883000
Front Biosci (Landmark Ed). 2009 Jan 01;14(3):1116-28
pubmed: 19273119
Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14376-81
pubmed: 11121041
Nat Rev Mol Cell Biol. 2008 Jul;9(7):532-42
pubmed: 18568041
Trends Microbiol. 2001 Mar;9(3):113-4
pubmed: 11303500
Biology (Basel). 2021 Mar 02;10(3):
pubmed: 33801564
Virchows Arch B Cell Pathol. 1975;18(2):119-27
pubmed: 807028
Am J Surg Pathol. 1997 Jan;21(1):88-101
pubmed: 8990145
Science. 1997 Feb 21;275(5303):1132-6
pubmed: 9027315
Ageing Res Rev. 2016 Dec;32:150-168
pubmed: 26947122
Nat Med. 2007 Jan;13(1):54-61
pubmed: 17187072
Nat Rev Cancer. 2002 Jun;2(6):420-30
pubmed: 12189384
Cell Res. 2014 Jan;24(1):9-23
pubmed: 24366340
Science. 2018 Nov 2;362(6414):
pubmed: 30385548
Aging Cell. 2021 Dec;20(12):e13512
pubmed: 34761505
Immunol Rev. 2017 May;277(1):61-75
pubmed: 28462526
Int J Cancer. 2021 Oct 1;149(7):1408-1420
pubmed: 34028029
Circ Res. 2019 Apr 12;124(8):1166-1168
pubmed: 30973815
Cancer Gene Ther. 2020 May;27(5):267-269
pubmed: 31467365
Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):817-25
pubmed: 18433711
Nat Rev Mol Cell Biol. 2014 Feb;15(2):135-47
pubmed: 24452471
Exp Neurol. 2009 Aug;218(2):193-202
pubmed: 19332058
Cell Mol Life Sci. 2022 Jan 9;79(1):60
pubmed: 35000037
Exp Mol Med. 2021 Apr;53(4):528-536
pubmed: 33854187
Mol Cell Oncol. 2015 Jan 26;2(3):e985913
pubmed: 27308466
Am J Cancer Res. 2021 Jul 15;11(7):3496-3514
pubmed: 34354857
Ann N Y Acad Sci. 2008 Dec;1147:233-41
pubmed: 19076445
Front Cell Dev Biol. 2021 Apr 06;9:653812
pubmed: 33937254
J Cell Sci. 2013 May 1;126(Pt 9):1905-12
pubmed: 23720375
Sci Rep. 2018 Jul 17;8(1):10834
pubmed: 30018415
Nat Rev Mol Cell Biol. 2014 Jan;15(1):49-63
pubmed: 24355989
Sci Rep. 2023 Jan 27;13(1):1483
pubmed: 36707625
Nat Chem Biol. 2017 Jan;13(1):91-98
pubmed: 27842070
Exp Mol Med. 2022 Jun;54(6):720-729
pubmed: 35764882
Pharmacol Ther. 2016 Jun;162:120-33
pubmed: 26802901
Sci Immunol. 2018 Aug 24;3(26):
pubmed: 30143555
Signal Transduct Target Ther. 2021 Feb 3;6(1):49
pubmed: 33536413
J Cell Mol Med. 2019 Aug;23(8):4854-4865
pubmed: 31210425
Apoptosis. 2022 Oct;27(9-10):697-719
pubmed: 35986803
Autophagy. 2007 May-Jun;3(3):282-4
pubmed: 17329965
Cell. 2008 Jan 11;132(1):27-42
pubmed: 18191218
Cell Death Discov. 2019 Aug 5;5:127
pubmed: 31396404
Toxicology. 2002 Dec 27;181-182:471-4
pubmed: 12505355
Hepatology. 2015 Aug;62(2):657-8
pubmed: 25376517
Apoptosis. 2021 Jun;26(5-6):277-292
pubmed: 33811561
Arch Pathol Lab Med. 2008 Oct;132(10):1551-6
pubmed: 18834208
Front Cell Dev Biol. 2021 Jan 12;8:607844
pubmed: 33585447
Toxicology. 2003 Jul 15;189(1-2):147-63
pubmed: 12821289
Science. 2000 Dec 1;290(5497):1717-21
pubmed: 11099404
Cell Res. 2019 May;29(5):347-364
pubmed: 30948788
EMBO J. 2017 Jul 3;36(13):1811-1836
pubmed: 28596378
Cell. 2011 Nov 11;147(4):742-58
pubmed: 22078876
Toxicol Pathol. 2007 Jun;35(4):495-516
pubmed: 17562483
Nat Med. 2016 Feb;22(2):146-53
pubmed: 26779811
Oncogene. 2008 Oct 27;27(50):6434-51
pubmed: 18955971
Cytokine Growth Factor Rev. 2011 Aug;22(4):189-95
pubmed: 22019906
J Cell Mol Med. 2021 Jun 18;:
pubmed: 34145735
Curr Opin Microbiol. 2021 Feb;59:42-49
pubmed: 32829024
Annu Rev Immunol. 2015;33:79-106
pubmed: 25493335
Biomed Pharmacother. 2019 Nov;119:109415
pubmed: 31514065
Cell Death Dis. 2020 Nov 26;11(11):1013
pubmed: 33243969
Blood. 2013 Oct 17;122(16):2784-94
pubmed: 24009232
Cell Rep. 2014 Aug 7;8(3):883-96
pubmed: 25066128
Redox Biol. 2020 May;32:101494
pubmed: 32199332
Br J Pharmacol. 2014 Apr;171(8):2000-16
pubmed: 24684389
J Immunol. 2011 Sep 1;187(5):2748-54
pubmed: 21804020
Biochemistry (Mosc). 2020 Dec;85(12):1484-1498
pubmed: 33705288
Cell Mol Life Sci. 2016 Jun;73(11-12):2379-86
pubmed: 27048820
Exp Mol Pathol. 2021 Aug;121:104660
pubmed: 34116021
Signal Transduct Target Ther. 2022 May 13;7(1):158
pubmed: 35562341
Front Immunol. 2018 Oct 16;9:2379
pubmed: 30459758
Infect Immun. 2011 Sep;79(9):3633-41
pubmed: 21708993
Hepat Mon. 2012 Aug;12(8):e6159
pubmed: 23087751
Nat Rev Immunol. 2017 Feb;17(2):97-111
pubmed: 27748397
Cell Rep. 2017 Jul 5;20(1):201-210
pubmed: 28683313
Lab Invest. 2010 Jul;90(7):970-84
pubmed: 20458277
Cell Chem Biol. 2023 Feb 16;30(2):130-143.e5
pubmed: 36708709
J Physiol Sci. 2015 Jan;65(1):11-24
pubmed: 24994533
Biochim Biophys Acta. 2015 Feb;1852(2):271-6
pubmed: 24859226
J Cell Biol. 2007 Jul 30;178(3):517-27
pubmed: 17646397
Biomed Res Int. 2015;2015:417590
pubmed: 25861623
Cancer Biol Ther. 2013 Nov;14(11):999-1004
pubmed: 24025353
Signal Transduct Target Ther. 2018 Jul 1;3:18
pubmed: 29967689
Front Cell Dev Biol. 2021 Jan 21;8:630771
pubmed: 33553170
Curr Opin Microbiol. 2013 Jun;16(3):319-26
pubmed: 23707339
Annu Rev Immunol. 2013;31:51-72
pubmed: 23157435
Oncotarget. 2016 Aug 23;7(34):55863-55889
pubmed: 27331412
iScience. 2021 Jul 24;24(8):102902
pubmed: 34401679
Nat Rev Mol Cell Biol. 2008 Dec;9(12):1004-10
pubmed: 18971948
Eur J Biochem. 1983 Dec 15;137(3):391-7
pubmed: 6319122
Cell Discov. 2020 May 26;6(1):32
pubmed: 32509328
Exp Mol Med. 2021 Jun;53(6):1007-1017
pubmed: 34075202
Redox Biol. 2018 Apr;14:361-370
pubmed: 29049980
Exp Mol Med. 2017 Aug 11;49(8):e365
pubmed: 28798402
Front Cell Infect Microbiol. 2020 Jun 03;10:238
pubmed: 32582562
Nature. 2008 Feb 28;451(7182):1069-75
pubmed: 18305538
Cell Death Discov. 2020 Jan 23;6:4
pubmed: 32123580
Nat Rev Microbiol. 2009 Feb;7(2):99-109
pubmed: 19148178
Annu Rev Genet. 2009;43:95-118
pubmed: 19659442
PLoS Biol. 2022 Apr 26;20(4):e3001614
pubmed: 35472045
J Clin Invest. 2020 Jun 1;130(6):2978-2991
pubmed: 32364533
Genes Dev. 2006 Jan 1;20(1):1-15
pubmed: 16391229
Science. 2016 Oct 7;354(6308):
pubmed: 27846469
Methods Mol Biol. 2010;648:93-106
pubmed: 20700707
Anat Embryol (Berl). 1996 Feb;193(2):81-99
pubmed: 8742050
Onco Targets Ther. 2016 Oct 17;9:6343-6360
pubmed: 27799782
Nat Rev Immunol. 2018 Feb;18(2):134-147
pubmed: 28990587
Nat Cell Biol. 2014 Dec;16(12):1180-91
pubmed: 25402683
Science. 2004 Mar 5;303(5663):1532-5
pubmed: 15001782
Cell Rep. 2018 Mar 13;22(11):2924-2936
pubmed: 29539421
Cell Death Differ. 2004 Oct;11(10):1066-75
pubmed: 15195070
Am J Pathol. 1995 Jan;146(1):3-15
pubmed: 7856735
J Pathol Bacteriol. 1965 Oct;90(2):419-35
pubmed: 5849603
JACC Basic Transl Sci. 2020 Aug 24;5(8):857-869
pubmed: 32875173
Biochim Biophys Acta. 2012 Jan;1824(1):22-33
pubmed: 21914490
Cell Res. 2014 Nov;24(11):1299-310
pubmed: 25342560
Hepatology. 2016 Dec;64(6):1994-2014
pubmed: 27637015
Front Cell Dev Biol. 2020 Oct 07;8:590226
pubmed: 33117818
Mol Oncol. 2020 Dec;14(12):2994-3006
pubmed: 33179413
Biometals. 2004 Aug;17(4):379-87
pubmed: 15259358
CA Cancer J Clin. 2005 May-Jun;55(3):178-94
pubmed: 15890640
Nat Commun. 2020 Jun 19;11(1):3151
pubmed: 32561730
Biochim Biophys Acta Mol Basis Dis. 2020 May 1;1866(5):165664
pubmed: 31926265
Cell Death Differ. 2005 Nov;12 Suppl 2:1463-7
pubmed: 16247491
Adv Sci (Weinh). 2023 May;10(14):e2205913
pubmed: 36960682
Biochemistry (Mosc). 2020 Oct;85(10):1178-1190
pubmed: 33202203
J Pathol. 2010 May;221(1):3-12
pubmed: 20225336
N Engl J Med. 2014 Jan 30;370(5):455-65
pubmed: 24476434
Essays Biochem. 2017 Dec 12;61(6):585-596
pubmed: 29233870
Cell Res. 2022 May;32(5):417-418
pubmed: 35354936
BMB Rep. 2018 May;51(5):219-224
pubmed: 29636122
Oncogene. 2004 Apr 12;23(16):2881-90
pubmed: 15077151
Front Immunol. 2013 Nov 11;4:365
pubmed: 24273539
Nat Rev Cancer. 2017 Sep;17(9):528-542
pubmed: 28751651
Biomolecules. 2019 Aug 14;9(8):
pubmed: 31416173
Cell. 2020 Apr 30;181(3):674-687.e13
pubmed: 32298652
Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):12736-7
pubmed: 9398063
Nat Rev Neurosci. 2019 Jan;20(1):19-33
pubmed: 30467385
Cell. 2007 Nov 30;131(5):966-79
pubmed: 18045538
Mol Cancer. 2020 Jan 22;19(1):12
pubmed: 31969156
Anaesthesia. 2000 Nov;55(11):1081-93
pubmed: 11069335
Cell Rep. 2017 Jan 17;18(3):647-658
pubmed: 28099844
Front Immunol. 2021 Nov 04;12:775267
pubmed: 34804066
Int J Mol Sci. 2021 Mar 24;22(7):
pubmed: 33805003
Cell Death Dis. 2020 Sep 30;11(9):817
pubmed: 32999282
J Mol Cell Cardiol. 2022 Apr;165:1-8
pubmed: 34919896
Biol Chem. 2012 Jul;393(7):547-64
pubmed: 22944659
Mol Cancer. 2023 Mar 7;22(1):46
pubmed: 36882769
Cell Adh Migr. 2011 Mar-Apr;5(2):170-80
pubmed: 21178402
Nat Rev Mol Cell Biol. 2009 Sep;10(9):623-35
pubmed: 19672277
Traffic. 2018 Dec;19(12):918-931
pubmed: 30125440
Cancer Cell. 2022 Sep 12;40(9):973-985.e7
pubmed: 36027915
Biochim Biophys Acta. 2016 Dec;1863(12):2977-2992
pubmed: 27646922
Biochim Biophys Acta Mol Cell Res. 2018 Jun;1865(6):831-841
pubmed: 29548938
Biomed J. 2017 Jun;40(3):133-140
pubmed: 28651734
Nat Immunol. 2015 Sep;16(9):907-17
pubmed: 26287597
Autophagy. 2007 Nov-Dec;3(6):663-6
pubmed: 17622797
Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20364-71
pubmed: 24277826
Curr Biol. 2011 Nov 8;21(21):R877-83
pubmed: 22075424
Immunity. 2021 Feb 9;54(2):247-258.e7
pubmed: 33444549
Science. 1995 Mar 10;267(5203):1456-62
pubmed: 7878464
J Pathol. 1971 Sep;105(1):13-20
pubmed: 4108566
Mol Cancer Res. 2010 Oct;8(10):1358-74
pubmed: 20713492
Oncotarget. 2014 Aug 30;5(16):6816-31
pubmed: 25149175
Mol Cancer. 2011 Jun 06;10:69
pubmed: 21639944
Nat Rev Mol Cell Biol. 2020 Feb;21(2):85-100
pubmed: 31636403
Int J Mol Sci. 2022 Apr 30;23(9):
pubmed: 35563375
Proc Natl Acad Sci U S A. 2023 Mar 7;120(10):e2216722120
pubmed: 36848556
J Exp Med. 2005 Dec 19;202(12):1691-701
pubmed: 16365148
J Biol Chem. 2009 Sep 4;284(36):24306-19
pubmed: 19561079
Carcinogenesis. 2000 Mar;21(3):485-95
pubmed: 10688869
Inorg Chem. 2019 Oct 21;58(20):13528-13545
pubmed: 31247859
Lond Med J. 1786;7(Pt 3):263-279
pubmed: 29139835
Mol Cancer Res. 2008 Jun;6(6):965-77
pubmed: 18567800
Signal Transduct Target Ther. 2022 Nov 23;7(1):378
pubmed: 36414625
Autophagy. 2017;13(12):2015-2017
pubmed: 28837378
Br J Cancer. 1972 Aug;26(4):239-57
pubmed: 4561027
Am J Pathol. 2014 Jun;184(6):1630-42
pubmed: 24726643
Science. 2002 May 31;296(5573):1635-6
pubmed: 12040174
J Physiol. 2000 Nov 15;529 Pt 1:57-68
pubmed: 11080251
Trends Biochem Sci. 2007 Jan;32(1):37-43
pubmed: 17141506
Nature. 2011 Oct 16;479(7371):117-21
pubmed: 22002608
Sci Immunol. 2016 Aug 5;1(2):
pubmed: 27917412
Cell Res. 2014 Nov;24(11):1280-1
pubmed: 25342563
Cell. 2001 Feb 23;104(4):487-501
pubmed: 11239407
Immunol Rev. 2017 May;277(1):76-89
pubmed: 28462525
Cell Death Discov. 2022 Feb 17;8(1):70
pubmed: 35177586
Front Cell Infect Microbiol. 2019 Nov 26;9:406
pubmed: 31850239
FEBS Lett. 2010 Apr 2;584(7):1287-95
pubmed: 20083114
Front Oncol. 2022 Feb 23;12:858462
pubmed: 35280777
Science. 2022 Mar 18;375(6586):1254-1261
pubmed: 35298263
JBRA Assist Reprod. 2018 Mar 01;22(1):61-66
pubmed: 29266896
Annu Rev Cell Dev Biol. 2020 Oct 6;36:191-218
pubmed: 32663035
Nat Rev Mol Cell Biol. 2020 Aug;21(8):421-438
pubmed: 32457508
Membranes (Basel). 2020 Aug 03;10(8):
pubmed: 32756454
Int J Mol Sci. 2020 Feb 20;21(4):
pubmed: 32093389
Nature. 2015 Apr 2;520(7545):57-62
pubmed: 25799988
Cell Chem Biol. 2020 Apr 16;27(4):420-435
pubmed: 32160513
Biomed Pharmacother. 2020 Jan;121:109595
pubmed: 31710896
Cancer Res. 1991 Feb 1;51(3):794-8
pubmed: 1846317
Exp Mol Med. 2020 Jun;52(6):921-930
pubmed: 32591647
Cell Death Dis. 2017 Jan 5;8(1):e2526
pubmed: 28055012
Cell Death Differ. 2018 Mar;25(3):486-541
pubmed: 29362479
Chem Commun (Camb). 2015 May 14;51(39):8353-6
pubmed: 25882790
Cell Death Dis. 2020 Feb 3;11(2):88
pubmed: 32015325
Autophagy. 2014 Apr;10(4):549-51
pubmed: 24657946
Cell Death Differ. 2015 Mar;22(3):367-76
pubmed: 25257169
Nat Immunol. 2018 Feb;19(2):130-140
pubmed: 29255269
Nat Rev Nephrol. 2016 Jul;12(7):402-13
pubmed: 27241241
Autophagy. 2016 Aug 2;12(8):1425-8
pubmed: 27245739
Chin Med J (Engl). 2018 Jul 5;131(13):1513-1519
pubmed: 29941703
Cell Death Differ. 2009 Jan;16(1):3-11
pubmed: 18846107
Immunity. 2013 Feb 21;38(2):209-23
pubmed: 23438821
Gastroenterology. 2018 Apr;154(5):1480-1493
pubmed: 29248440
Biomolecules. 2012 Nov 12;2(4):524-48
pubmed: 24970148
Nat Rev Cancer. 2007 Dec;7(12):961-7
pubmed: 17972889
PLoS Biol. 2022 Apr 25;20(4):e3001586
pubmed: 35468130
World J Gastroenterol. 2014 Sep 21;20(35):12526-32
pubmed: 25253954
Mol Aspects Med. 1999 Jun;20(3):139-84
pubmed: 10626278
Nat Rev Cancer. 2012 Oct;12(10):685-98
pubmed: 23001348
J Mol Biol. 2022 Feb 28;434(4):167301
pubmed: 34653436
Cell. 2012 May 25;149(5):1060-72
pubmed: 22632970
Int J Oncol. 2002 Jul;21(1):165-70
pubmed: 12063564
Exp Oncol. 2012 Oct;34(3):146-52
pubmed: 23069998
Mol Cancer. 2019 May 23;18(1):100
pubmed: 31122251
J Exp Med. 2017 Aug 7;214(8):2217-2229
pubmed: 28634194
Nat Rev Mol Cell Biol. 2007 Nov;8(11):931-7
pubmed: 17712358
J Cell Mol Med. 2019 Aug;23(8):4900-4912
pubmed: 31232522
Cold Spring Harb Perspect Biol. 2015 Dec 01;7(12):
pubmed: 26626938