Non-cell-autonomous cancer progression from chromosomal instability.

Humans Benchmarking Cell Communication Chromosomal Instability Colorectal Neoplasms / drug therapy Disease Progression Melanoma / drug therapy Tumor Microenvironment Interferon Type I / immunology Neoplasm Metastasis Endoplasmic Reticulum Stress Signal Transduction Triple Negative Breast Neoplasms / drug therapy Neoplasms / genetics

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
Aug 2023
Historique:
received: 09 12 2021
accepted: 20 07 2023
medline: 1 9 2023
pubmed: 24 8 2023
entrez: 23 8 2023
Statut: ppublish

Résumé

Chromosomal instability (CIN) is a driver of cancer metastasis

Identifiants

DOI: 10.1038/s41586-023-06464-z PMID: 37612508 PMC: PMC10468402
pubmed: 37612508
doi: 10.1038/s41586-023-06464-z
pii: 10.1038/s41586-023-06464-z
pmc: PMC10468402
doi:

Substances chimiques

cGAS protein, human EC 2.7.7.-
STING1 protein, human 0
Interferon Type I 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1080-1088

Subventions

Organisme : NCI NIH HHS
ID : R01 CA280414
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA263381
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA280572
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA266660
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA256188
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2023. The Author(s).

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Auteurs

Jun Li (J)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0002-6836-2716

Melissa J Hubisz (MJ)

Department of Physiology, Biophysics, and Systems Biology, Weill Cornell Medicine, New York, NY, USA.
Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Bioinformatics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY, USA.
ORCID: 0000-0002-9561-6830

Ethan M Earlie (EM)

Department of Physiology, Biophysics, and Systems Biology, Weill Cornell Medicine, New York, NY, USA.
Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0003-3039-9692

Mercedes A Duran (MA)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0009-0002-9974-4095

Christy Hong (C)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Austin A Varela (AA)

Department of Physiology, Biophysics, and Systems Biology, Weill Cornell Medicine, New York, NY, USA.
Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-9068-7605

Emanuele Lettera (E)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Matthew Deyell (M)

Department of Physiology, Biophysics, and Systems Biology, Weill Cornell Medicine, New York, NY, USA.
Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0009-0009-6543-1171

Bernardo Tavora (B)

Volastra Therapeutics Inc., New York, NY, USA.

Jonathan J Havel (JJ)

Volastra Therapeutics Inc., New York, NY, USA.
ORCID: 0000-0003-0951-510X

Su M Phyu (SM)

Department of Oncology, Medical Sciences Division, University of Oxford, Oxford, UK.
ORCID: 0000-0003-1775-6966

Amit Dipak Amin (AD)

Columbia Center for Translational Immunology, New York, NY, USA.
Division of Hematology and Oncology, Columbia University Medical Center, New York, NY, USA.
ORCID: 0000-0002-2613-2082

Karolina Budre (K)

Department of Physiology, Biophysics, and Systems Biology, Weill Cornell Medicine, New York, NY, USA.
Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.

Erina Kamiya (E)

Department of Physiology, Biophysics, and Systems Biology, Weill Cornell Medicine, New York, NY, USA.
Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0001-9048-5125

Julie-Ann Cavallo (JA)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Christopher Garris (C)

Department of Pathology, Harvard Medical School, Boston, MA, USA.
Center for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.

Simon Powell (S)

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0002-8183-4765

Jorge S Reis-Filho (JS)

Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0003-2969-3173

Hannah Wen (H)

Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Sarah Bettigole (S)

Volastra Therapeutics Inc., New York, NY, USA.

Atif J Khan (AJ)

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Benjamin Izar (B)

Columbia Center for Translational Immunology, New York, NY, USA.
Division of Hematology and Oncology, Columbia University Medical Center, New York, NY, USA.
ORCID: 0000-0003-2379-6702

Eileen E Parkes (EE)

Department of Oncology, Medical Sciences Division, University of Oxford, Oxford, UK.

Ashley M Laughney (AM)

Department of Physiology, Biophysics, and Systems Biology, Weill Cornell Medicine, New York, NY, USA. ashley.laughney@gmail.com.
Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. ashley.laughney@gmail.com.
Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA. ashley.laughney@gmail.com.
ORCID: 0000-0001-9435-953X

Samuel F Bakhoum (SF)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. samuel.bakhoum@gmail.com.
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. samuel.bakhoum@gmail.com.
ORCID: 0000-0002-4779-8422

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questionsmedicales.fr › Phénomènes génétiques › Instabilité du génome › Instabilité des chromosomes › Non-cell-autonomous cancer progression from...
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