Successful cognitive aging is associated with thicker anterior cingulate cortex and lower tau deposition compared to typical aging.
Alzheimer's disease
PET
amyloid
biomarkers
cortical thickness
exceptional cognitive performance
successful aging
superaging
tau
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
24 Aug 2023
24 Aug 2023
Historique:
revised:
30
06
2023
received:
12
04
2023
accepted:
01
08
2023
medline:
24
8
2023
pubmed:
24
8
2023
entrez:
24
8
2023
Statut:
aheadofprint
Résumé
There is no consensus on either the definition of successful cognitive aging (SA) or the underlying neural mechanisms. We examined the agreement between new and existing definitions using: (1) a novel measure, the cognitive age gap (SA-CAG, cognitive-predicted age minus chronological age), (2) composite scores for episodic memory (SA-EM), (3) non-memory cognition (SA-NM), and (4) the California Verbal Learning Test (SA-CVLT). Fair to moderate strength of agreement was found between the four definitions. Most SA groups showed greater cortical thickness compared to typical aging (TA), especially in the anterior cingulate and midcingulate cortices and medial temporal lobes. Greater hippocampal volume was found in all SA groups except SA-NM. Lower entorhinal These findings suggest that a feature of SA, regardless of its exact definition, is resistance to tau pathology and preserved cortical integrity, especially in the anterior cingulate and midcingulate cortices. Different approaches have been used to define successful cognitive aging (SA). Regardless of definition, different SA groups have similar brain features. SA individuals have greater anterior cingulate thickness and hippocampal volume. Lower entorhinal tau deposition, but not amyloid beta is related to SA. A combination of cortical integrity and resistance to tau may be features of SA.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : AG067418
Pays : United States
Organisme : Alzheimer's Association
ID : AARF-22-926053
Pays : United States
Organisme : NIH HHS
ID : AG034570
Pays : United States
Organisme : NIA NIH HHS
ID : K01 AG078443
Pays : United States
Organisme : NIA NIH HHS
ID : R03 AG067033
Pays : United States
Informations de copyright
© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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