Antibiotic Treatment Prior to Injury Abrogates the Detrimental Effects of LPS in
CHONDROCYTE AND CARTILAGE BIOLOGY
DISEASES AND DISORDERS OF/RELATED TO BONE
OSTEOARTHRITIS
THERAPEUTICS
Journal
JBMR plus
ISSN: 2473-4039
Titre abrégé: JBMR Plus
Pays: England
ID NLM: 101707013
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
16
11
2022
revised:
08
04
2023
accepted:
12
04
2023
medline:
24
8
2023
pubmed:
24
8
2023
entrez:
24
8
2023
Statut:
epublish
Résumé
Post traumatic osteoarthritis (PTOA) is a form of secondary osteoarthritis (OA) that develops in ~50% of cases of severe articular joint injuries and leads to chronic and progressive degradation of articular cartilage and other joint tissues. PTOA progression can be exacerbated by repeated injury and systemic inflammation. Few studies have examined approaches for blunting or slowing down PTOA progression with emphasis on systemic inflammation; most arthritis studies focused on the immune system have been in the context of rheumatoid arthritis. To examine how the gut microbiome affects systemic inflammation during PTOA development, we used a chronic antibiotic treatment regimen starting at weaning for 6 weeks before anterior cruciate ligament (ACL) rupture in
Identifiants
pubmed: 37614305
doi: 10.1002/jbm4.10759
pii: JBM410759
pmc: PMC10443070
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e10759Informations de copyright
© 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Références
J Travel Med. 2017 Apr 1;24(suppl_1):S35-S38
pubmed: 28520993
Dermatitis. 2010 Jan-Feb;21(1):3-7
pubmed: 20137735
Front Nutr. 2022 Sep 20;9:1012087
pubmed: 36204373
Br J Anaesth. 1981 Dec;53(12):1243-5
pubmed: 7317242
Nature. 2012 May 09;486(7402):222-7
pubmed: 22699611
J Bone Miner Res. 2020 Nov;35(11):2229-2241
pubmed: 32564401
Osteoarthritis Cartilage. 2021 Dec;29(12):1709-1719
pubmed: 34653605
Int J Mol Sci. 2021 Jun 10;22(12):
pubmed: 34200555
PeerJ. 2019 Aug 16;7:e7502
pubmed: 31440436
J Orthop Res. 2014 Jan;32(1):79-88
pubmed: 24019199
Rev Med Chil. 1990 May;118(5):548-54
pubmed: 2293275
J Orthop Res. 2017 Mar;35(3):474-485
pubmed: 27088242
Int J Mol Sci. 2018 Sep 07;19(9):
pubmed: 30205482
Int J Mol Sci. 2020 Sep 03;21(17):
pubmed: 32899361
Osteoarthritis Cartilage. 2015 Oct;23(10):1627-38
pubmed: 26003950
Osteoarthritis Cartilage. 2001 Feb;9(2):85-91
pubmed: 11237655
Gut Microbes. 2012 Jan-Feb;3(1):4-14
pubmed: 22356853
J Bone Miner Res. 2018 Jun;33(6):1105-1113
pubmed: 29377313
Bone Joint Res. 2022 Apr;11(4):214-225
pubmed: 35382556
Comp Med. 2011 Aug;61(4):346-55
pubmed: 22330250
J Travel Med. 2017 Apr 1;24(suppl_1):S52-S56
pubmed: 28521002
J Bone Miner Res. 2010 Jul;25(7):1468-86
pubmed: 20533309
Arthritis Rheum. 2013 Jun;65(6):1569-78
pubmed: 23436303
Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S17-23
pubmed: 20864019
JCI Insight. 2018 Apr 19;3(8):
pubmed: 29669931
Osteoarthritis Cartilage. 2019 Jan;27(1):129-139
pubmed: 30240938