The association of adverse reactions and depression in cervical cancer patients treated with radiotherapy and/or chemotherapy: moderated mediation models.
adverse reactions
cervical cancer
depression
mediation
moderation
patient
Journal
Frontiers in psychology
ISSN: 1664-1078
Titre abrégé: Front Psychol
Pays: Switzerland
ID NLM: 101550902
Informations de publication
Date de publication:
2023
2023
Historique:
received:
17
04
2023
accepted:
12
06
2023
medline:
24
8
2023
pubmed:
24
8
2023
entrez:
24
8
2023
Statut:
epublish
Résumé
Several studies reported that adverse reactions to treatment, neuroticism, marital relations, and quality of life may impact the development of depression in cervical cancer patients treated with radiotherapy and/or chemotherapy, but the associations between them remained unclear. This study investigated the associations between these factors using moderated mediation models. Data were extracted from a survey involving cervical cancer patients treated with radiotherapy and/or chemotherapy at five tertiary hospitals in Hubei Province, China, from June to December 2022. The SPSS-PROCESS program was used to develop a moderated mediation model to study the roles of neuroticism, quality of life, and marital relations in the association between adverse reactions and depression in the study population. A total of 802 cervical cancer patients treated with radiotherapy and/or chemotherapy (54.84 ± 9.68 years) were recruited. The prevalence of depression among these patients was 72.72%, with four symptom clusters of dizziness-ringing in the ears, digestive system-related symptoms, skin dryness and itching, and urinary frequency-urgency-leakage. Adverse reactions directly and positively affected the occurrence of depression, neuroticism mediated the association between adverse reactions and depression, while this association varied according to the quality of life and marital relations. Our findings suggest that depression is common among cervical cancer patients receiving radiotherapy and/or chemotherapy. Intervention targets for depression in cervical cancer patients should be precisely selected and targeted according to the quality of life and marital relations differences in patients, taking into account the cost of the intervention and the benefit to the patient.
Identifiants
pubmed: 37614487
doi: 10.3389/fpsyg.2023.1207265
pmc: PMC10442555
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1207265Informations de copyright
Copyright © 2023 Ding, Zhang, Wang, Huang, Liu, Han and Hu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Int J Environ Res Public Health. 2016 Dec 26;14(1):
pubmed: 28035968
J Pain Symptom Manage. 2017 Apr;53(4):751-758
pubmed: 28042061
Patient Prefer Adherence. 2022 May 26;16:1359-1369
pubmed: 35651663
J Psychiatr Res. 2018 Aug;103:150-155
pubmed: 29852422
J Affect Disord. 2016 Jan 15;190:744-753
pubmed: 26606718
Qual Life Res. 2019 Oct;28(10):2641-2650
pubmed: 31187410
Cancer Radiother. 2019 Apr;23(2):151-160
pubmed: 30898418
Oncol Nurs Forum. 2001 Apr;28(3):465-70
pubmed: 11338755
J Affect Disord. 2023 Feb 15;323:482-489
pubmed: 36496103
Psychol Bull. 1984 Nov;96(3):465-90
pubmed: 6393179
Fam Process. 2007 Dec;46(4):485-98
pubmed: 18092581
J Gerontol B Psychol Sci Soc Sci. 1998 Mar;53(2):P73-85
pubmed: 9520924
J Pers Assess. 1990 Winter;55(3-4):610-7
pubmed: 2280326
Expert Opin Pharmacother. 2010 Apr;11(6):1003-14
pubmed: 20307224
Nat Clin Pract Oncol. 2008 Aug;5(8):466-75
pubmed: 18493231
J Cancer Res Ther. 2016 Apr-Jun;12(2):938-44
pubmed: 27461678
BMC Cancer. 2017 Aug 1;17(1):510
pubmed: 28764676
Annu Rev Psychol. 2022 Jan 4;73:489-516
pubmed: 34516758
Depress Anxiety. 2000;12 Suppl 1:95-101
pubmed: 11098422
J Pain Symptom Manage. 2021 Mar;61(3):544-554
pubmed: 32828931
Gynecol Oncol. 2014 Dec;135(3):510-7
pubmed: 25281491
Am Psychol. 2019 Dec;74(9):1056-1067
pubmed: 31829685
Cancer. 2009 Nov 15;115(22):5349-61
pubmed: 19753617
Arch Gynecol Obstet. 2019 Apr;299(4):1033-1041
pubmed: 30488281
Psychol Aging. 2003 Mar;18(1):25-37
pubmed: 12641310
Cancer. 2000 Apr 1;88(7):1715-27
pubmed: 10738232
Dermatology. 2022;238(3):448-453
pubmed: 34515100
Drugs. 2015 Apr;75(5):487-501
pubmed: 25795100
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2019 Aug 30;41(4):501-505
pubmed: 31484612
BMC Cancer. 2021 Mar 31;21(1):330
pubmed: 33789613
Cancer. 2010 Jul 1;116(13):3304; author reply 3304-5
pubmed: 20564636
Acta Derm Venereol. 2016 Jan;96(1):50-5
pubmed: 26067841
Eur J Cancer Care (Engl). 2017 Sep;26(5):
pubmed: 26786536
Eur J Cancer Care (Engl). 2007 Mar;16(2):130-6
pubmed: 17371421
Arch Gynecol Obstet. 2016 May;293(5):1053-63
pubmed: 26335186
Health Qual Life Outcomes. 2006 Oct 11;4:79
pubmed: 17034633
Psychol Med. 2010 Nov;40(11):1797-810
pubmed: 20085667
Fam Process. 2007 Dec;46(4):499-514
pubmed: 18092582
J Gen Intern Med. 2001 Sep;16(9):606-13
pubmed: 11556941
J Affect Disord. 2011 Jan;128(1-2):64-71
pubmed: 20674034
J Affect Disord. 2020 Mar 15;265:611-617
pubmed: 31787420
J Dev Behav Pediatr. 2011 Apr;32(3):188-95
pubmed: 21263350
J Health Commun. 2012;17 Suppl 3:82-99
pubmed: 23030563