Breast Implant-Associated Tumors.

BIA-ALCL BIA-SCC breast implant immunostimulation implant-associated tumors lymphoma squamous cell carcinoma textured implants

Journal

Geburtshilfe und Frauenheilkunde
ISSN: 0016-5751
Titre abrégé: Geburtshilfe Frauenheilkd
Pays: Germany
ID NLM: 0370732

Informations de publication

Date de publication:
Jun 2023
Historique:
received: 06 02 2023
accepted: 13 04 2023
medline: 24 8 2023
pubmed: 24 8 2023
entrez: 24 8 2023
Statut: epublish

Résumé

In addition to anaplastic large T-cell lymphomas (BIA-ALCL), other implant-related tumors have been described for some years. Squamous cell carcinoma (SSC) and B-cell lymphomas occurred in very rare cases. The unexplained pathogenesis as well as the unclear individual risk profile is an ongoing source of uncertainty for patients and physicians. The pathogenesis of the tumors is still largely not understood. While BIA-ALCL occurs more frequently with textured breast implants, other tumors were also observed with smooth implants and at other implant sites. Multiple potential mechanisms are discussed. It is suspected that the etiology of a chronic inflammatory response and subsequently immunostimulation is multifactorial and appears to play a key role in the malignant transformation. Since there are currently no sufficiently valid data for a specific risk assessment, this must be done with caution. This article presents the incidence, pathogenesis, as well as the level of evidence according to the current state of knowledge, and evaluates and discusses the current literature.

Identifiants

pubmed: 37614684
doi: 10.1055/a-2073-9534
pii: GebFra-2023-02-1945-U
pmc: PMC10444514
doi:

Types de publication

Journal Article

Langues

eng

Pagination

686-693

Informations de copyright

The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Déclaration de conflit d'intérêts

Conflict of Interest The authors declare that they have no conflict of interest.

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Auteurs

Uwe von Fritschen (U)

Department of Plastic- and Aesthetic Surgery, Helios Klinik Emil von Behring, Berlin, Germany.

Thomas Kremer (T)

Klinik für Plastische und Handchirurgie mit Schwerbrandverletztenzentrum, Klinikum St. Georg, Dresden, Germany.

Lukas Prantl (L)

Abteilung für Plastische-, Hand- und Rekonstruktive Chirurgie, Universität Regensburg, Regensburg, Germany.

Alba Fricke (A)

Department of Plastic- and Aesthetic Surgery, Helios Klinik Emil von Behring, Berlin, Germany.
Department of Plastic and Hand Surgery, University of Freiburg Medical Centre, Medical Faculty of the University of Freiburg, Freiburg, Germany.

Classifications MeSH