An improved synthesis of [

Positron-Emission Tomography / methods Fluorine Radioisotopes Radiopharmaceuticals Brain / metabolism Neuroimaging Vesicular Acetylcholine Transport Proteins / metabolism
VAChT PET imaging [18F]VAT one step 18F-fluorination selective ring-opening amination

Journal

Journal of labelled compounds & radiopharmaceuticals
ISSN: 1099-1344
Titre abrégé: J Labelled Comp Radiopharm
Pays: England
ID NLM: 7610510

Informations de publication

Date de publication:
10 2023
Historique:
revised: 07 08 2023
received: 01 06 2023
accepted: 09 08 2023
pmc-release: 01 10 2024
medline: 4 10 2023
pubmed: 24 8 2023
entrez: 24 8 2023
Statut: ppublish

Résumé

The vesicular acetylcholine transporter (VAChT) in the brain is an important presynaptic cholinergic biomarker, and neuroimaging studies of VAChT may provide in vivo information about psychiatric and neurologic conditions including Alzheimer's disease that are not accessible by other methods. The

Identifiants

DOI: 10.1002/jlcr.4059 PMID: 37615234 PMC: PMC10592132
pubmed: 37615234
doi: 10.1002/jlcr.4059
pmc: PMC10592132
mid: NIHMS1925410
doi:

Substances chimiques

Fluorine Radioisotopes 0
Radiopharmaceuticals 0
Vesicular Acetylcholine Transport Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

384-392

Subventions

Organisme : NIBIB NIH HHS
ID : R01 EB031785
Pays : United States

Informations de copyright

© 2023 John Wiley & Sons Ltd.

Références

J Neurosci. 1996 Apr 1;16(7):2179-90
pubmed: 8601799
Bioorg Med Chem. 2015 Aug 1;23(15):4699-4709
pubmed: 26138195
J Comp Neurol. 1983 Feb 20;214(2):170-97
pubmed: 6841683
J Med Chem. 1992 Feb 7;35(3):480-9
pubmed: 1346652
ACS Chem Neurosci. 2021 May 5;12(9):1472-1479
pubmed: 33890459
Inorg Chem. 2003 Nov 3;42(22):7258-65
pubmed: 14577795
EJNMMI Res. 2015 Dec;5(1):73
pubmed: 26660544
J Comp Neurol. 1997 Feb 24;378(4):454-67
pubmed: 9034903
Org Biomol Chem. 2010 Oct 7;8(19):4297-307
pubmed: 20717621
Appl Radiat Isot. 2016 Jan;107:40-46
pubmed: 26408913
Org Biomol Chem. 2017 Feb 22;15(8):1913-1920
pubmed: 28169381
Science. 1997 Aug 15;277(5328):936-8
pubmed: 9252321

Auteurs

Bao Hu (B)

Department of Psychiatry and Behavioral Health, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
Department of Chemistry, Stony Brook University, Stony Brook, New York, USA.

Hari K Akula (HK)

Department of Psychiatry and Behavioral Health, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
Department of Chemistry, Stony Brook University, Stony Brook, New York, USA.
PET Research Core, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.

Doyoung Noh (D)

Department of Psychiatry and Behavioral Health, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
PET Research Core, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.

Yiu Fung Mui (YF)

Department of Psychiatry and Behavioral Health, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
PET Research Core, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.

Mark Slifstein (M)

Department of Psychiatry and Behavioral Health, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
PET Research Core, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.

Ramin Parsey (R)

Department of Psychiatry and Behavioral Health, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
PET Research Core, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.

Wenchao Qu (W)

Department of Psychiatry and Behavioral Health, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
Department of Chemistry, Stony Brook University, Stony Brook, New York, USA.
PET Research Core, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
ORCID: 0000-0003-3107-7281

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Classifications MeSH

questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › An improved synthesis of [
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes du fluor › An improved synthesis of [
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Radiopharmaceutiques › An improved synthesis of [
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › An improved synthesis of [
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › An improved synthesis of [
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs de neurotransmetteurs › Transporteurs vésiculaires des neurotransmetteurs › Transporteurs vésiculaires des amines biogènes › Transporteurs vésiculaires de l'acétylcholine › An improved synthesis of [