Investigating causal associations among gut microbiota, gut microbiota-derived metabolites, and gestational diabetes mellitus: a bidirectional Mendelian randomization study.
Mendelian randomization
causal association
gestational diabetes mellitus
gut microbiota
gut microbiota-derived metabolites
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
23 08 2023
23 08 2023
Historique:
received:
17
05
2023
accepted:
20
07
2023
medline:
7
9
2023
pubmed:
24
8
2023
entrez:
24
8
2023
Statut:
ppublish
Résumé
Previous studies have shown that gut microbiota (GM) and gut microbiota-derived metabolites are associated with gestational diabetes mellitus (GDM). However, the causal associations need to be treated with caution due to confounding factors and reverse causation. This study obtained genetic variants from genome-wide association study including GM ( Greater abundance of The study first used the MR approach to explore the causal associations among GM, GM-derived metabolites, and GDM. Our findings may contribute to the prevention and treatment strategies for GDM by targeting GM and metabolites, and offer novel insights into the underlying mechanism of the disease.
Sections du résumé
BACKGROUND
Previous studies have shown that gut microbiota (GM) and gut microbiota-derived metabolites are associated with gestational diabetes mellitus (GDM). However, the causal associations need to be treated with caution due to confounding factors and reverse causation.
METHODS
This study obtained genetic variants from genome-wide association study including GM (
RESULTS
Greater abundance of
CONCLUSIONS
The study first used the MR approach to explore the causal associations among GM, GM-derived metabolites, and GDM. Our findings may contribute to the prevention and treatment strategies for GDM by targeting GM and metabolites, and offer novel insights into the underlying mechanism of the disease.
Identifiants
pubmed: 37616057
pii: 204973
doi: 10.18632/aging.204973
pmc: PMC10497006
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8345-8366Références
J Diabetes Res. 2021 Feb 05;2021:8885954
pubmed: 33628838
Diabetes Metab. 2010 Dec;36(6 Pt 2):617-27
pubmed: 21163425
Clin Sci (Lond). 2020 Jan 31;134(2):289-302
pubmed: 31961431
World J Diabetes. 2015 Jul 25;6(8):1065-72
pubmed: 26240703
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
Diabetes. 1985 Jun;34 Suppl 2:66-70
pubmed: 3888744
Genet Epidemiol. 2013 Nov;37(7):658-65
pubmed: 24114802
Genome Med. 2016 Apr 21;8(1):43
pubmed: 27102666
Genet Epidemiol. 2016 May;40(4):304-14
pubmed: 27061298
N Engl J Med. 2008 May 8;358(19):1991-2002
pubmed: 18463375
Microbiome. 2018 May 15;6(1):89
pubmed: 29764499
Nat Genet. 2021 Feb;53(2):156-165
pubmed: 33462485
Stat Med. 2018 Jul 20;37(16):2530-2546
pubmed: 29687470
Nat Genet. 2014 Jun;46(6):543-550
pubmed: 24816252
Stat Methods Med Res. 2007 Aug;16(4):309-30
pubmed: 17715159
Cell Host Microbe. 2015 Nov 11;18(5):582-92
pubmed: 26526499
Diabetologia. 2018 Apr;61(4):810-820
pubmed: 29379988
J Biosci Bioeng. 2014 Oct;118(4):476-81
pubmed: 24721123
Int J Epidemiol. 2003 Feb;32(1):1-22
pubmed: 12689998
Arch Microbiol. 1976 Apr 1;107(3):283-8
pubmed: 1275638
Nature. 2017 Nov 30;551(7682):648-652
pubmed: 29168502
Front Physiol. 2019 Aug 27;10:1030
pubmed: 31507429
PLoS One. 2013 Aug 27;8(8):e71108
pubmed: 24013136
Am J Clin Nutr. 2017 Sep;106(3):888-894
pubmed: 28724646
Bioinformatics. 2008 Dec 15;24(24):2938-9
pubmed: 18974171
Lancet. 2009 May 23;373(9677):1773-9
pubmed: 19465232
Diabetes. 2019 Sep;68(9):1747-1755
pubmed: 31167879
Front Cardiovasc Med. 2022 Mar 25;9:832092
pubmed: 35402559
Curr Diab Rep. 2016 Jan;16(1):7
pubmed: 26742932
Gut. 2021 Jun;70(6):1174-1182
pubmed: 33272977
Nucleic Acids Res. 2013 Jan;41(Database issue):D590-6
pubmed: 23193283
Int J Epidemiol. 2011 Jun;40(3):755-64
pubmed: 21414999
Int J Epidemiol. 2015 Apr;44(2):512-25
pubmed: 26050253
Front Cell Infect Microbiol. 2022 Aug 15;12:943427
pubmed: 36046745
J Clin Endocrinol Metab. 2019 Nov 1;104(11):5529-5539
pubmed: 31373635
Nat Genet. 2018 May;50(5):693-698
pubmed: 29686387
Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617
pubmed: 29140435
J Autoimmun. 2010 Aug;35(1):1-9
pubmed: 20061120
Nature. 2023 Jan;613(7944):508-518
pubmed: 36653562
EXCLI J. 2021 Feb 11;20:301-319
pubmed: 33746664
Curr Dev Nutr. 2022 Jun 21;6(7):nzac108
pubmed: 35949367
Exp Clin Endocrinol Diabetes. 2016 Apr;124(4):251-6
pubmed: 27123785
Stat Med. 2008 Apr 15;27(8):1133-63
pubmed: 17886233
J Pediatr Endocrinol Metab. 2001 Sep-Oct;14(8):1085-91
pubmed: 11592564
Front Microbiol. 2022 Dec 16;13:1059281
pubmed: 36590417
Int J Mol Sci. 2018 Oct 26;19(11):
pubmed: 30373146
Nat Commun. 2012;3:1245
pubmed: 23212374
Diab Vasc Dis Res. 2017 Mar;14(2):130-138
pubmed: 28185532
Front Cell Infect Microbiol. 2020 May 15;10:188
pubmed: 32500037
Stat Med. 2017 Dec 20;36(29):4705-4718
pubmed: 28960498
Cell Metab. 2020 Sep 1;32(3):379-390.e3
pubmed: 32652044
Gigascience. 2017 Aug 1;6(8):1-12
pubmed: 28873967
World J Diabetes. 2022 Oct 15;13(10):861-876
pubmed: 36311998
Nucleic Acids Res. 2018 Jul 2;46(W1):W486-W494
pubmed: 29762782
Am J Clin Nutr. 2018 Jul 1;108(1):163-173
pubmed: 29982310
Diabetes. 2022 Aug 1;71(8):1807-1817
pubmed: 35532743
J Lipid Res. 2015 Jan;56(1):22-37
pubmed: 25378658
Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-5
pubmed: 12883005
EBioMedicine. 2019 Sep;47:373-383
pubmed: 31492563
Nat Genet. 2019 Apr;51(4):600-605
pubmed: 30778224
J Hypertens. 2015 Apr;33(4):791-6; discussion 796
pubmed: 25490711
Nature. 2013 Jun 6;498(7452):99-103
pubmed: 23719380
Nat Med. 2013 May;19(5):576-85
pubmed: 23563705
Front Cardiovasc Med. 2022 Aug 30;9:944155
pubmed: 36110409
Diabetes. 2003 Mar;52(3):812-7
pubmed: 12606524