Midpregnancy Phthalate and Phenol Biomarkers in Relation to Infant Body Composition: The Healthy Start Prospective Cohort.
Journal
Environmental health perspectives
ISSN: 1552-9924
Titre abrégé: Environ Health Perspect
Pays: United States
ID NLM: 0330411
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
medline:
25
8
2023
pubmed:
24
8
2023
entrez:
24
8
2023
Statut:
ppublish
Résumé
Gestational phthalate and phenol exposure disrupts adipogenesis, contributing to obesity in mice. Whether gestational phthalate or phenol exposure is associated with infant body composition has not been investigated in humans. We examined associations between biomarkers of phthalate and phenol exposure in midpregnancy and infant size and body composition at birth and at 5 months of age. Analyses were conducted among 438 infants from the Healthy Start prospective pregnancy cohort. Sixteen phthalate and phenol biomarkers were quantified in spot urine samples collected at 24-28 wk of gestation. Infant outcomes measured at birth and at 5 months of age included size [weight (in grams)] and body composition [fat and lean masses (in grams); percentage fat mass]. Single- (linear) and multipollutant (quantile g-computation) models were used to estimate associations of phthalate and phenol biomarkers with infant outcomes at birth and at 5 months of age. Models were adjusted for sociodemographics, sample collection timing, and lifestyle factors and used to examine for effect modification by infant sex. In single-pollutant models, mono-benzyl phthalate and di- In this U.S.-based prospective cohort, gestational phthalate and phenol biomarkers were inversely associated with infant weight and fat mass, particularly in males. https://doi.org/10.1289/EHP12500.
Sections du résumé
BACKGROUND
Gestational phthalate and phenol exposure disrupts adipogenesis, contributing to obesity in mice. Whether gestational phthalate or phenol exposure is associated with infant body composition has not been investigated in humans.
OBJECTIVE
We examined associations between biomarkers of phthalate and phenol exposure in midpregnancy and infant size and body composition at birth and at 5 months of age.
METHODS
Analyses were conducted among 438 infants from the Healthy Start prospective pregnancy cohort. Sixteen phthalate and phenol biomarkers were quantified in spot urine samples collected at 24-28 wk of gestation. Infant outcomes measured at birth and at 5 months of age included size [weight (in grams)] and body composition [fat and lean masses (in grams); percentage fat mass]. Single- (linear) and multipollutant (quantile g-computation) models were used to estimate associations of phthalate and phenol biomarkers with infant outcomes at birth and at 5 months of age. Models were adjusted for sociodemographics, sample collection timing, and lifestyle factors and used to examine for effect modification by infant sex.
RESULTS
In single-pollutant models, mono-benzyl phthalate and di-
CONCLUSION
In this U.S.-based prospective cohort, gestational phthalate and phenol biomarkers were inversely associated with infant weight and fat mass, particularly in males. https://doi.org/10.1289/EHP12500.
Identifiants
pubmed: 37616158
doi: 10.1289/EHP12500
pmc: PMC10449008
doi:
Substances chimiques
Phenol
339NCG44TV
phthalic acid
6O7F7IX66E
Phenols
0
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
87017Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES010126
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK076648
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023248
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023248
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES022934
Pays : United States
Références
J Orthop Res. 2018 Apr;36(4):1124-1134
pubmed: 28921615
Int J Obes (Lond). 2022 Jan;46(1):121-128
pubmed: 34545176
Obesity (Silver Spring). 2018 Jul;26(7):1225-1233
pubmed: 29845756
Curr Environ Health Rep. 2015 Dec;2(4):348-55
pubmed: 26342608
Environ Health Perspect. 2017 Sep 11;125(9):097008
pubmed: 28935615
Med Hypotheses. 2017 Feb;99:73-75
pubmed: 28110704
Pediatr Obes. 2021 Jun;16(6):e12752
pubmed: 33205622
Toxicol Sci. 2013 Jan;131(1):56-70
pubmed: 22956630
Environ Res. 2022 Dec;215(Pt 2):114332
pubmed: 36116496
Environ Health Perspect. 2016 Oct;124(10):1644-1650
pubmed: 27187982
Am J Epidemiol. 2023 Jan 6;192(1):6-10
pubmed: 36222655
Environ Health Perspect. 2004 Dec;112(17):1691-6
pubmed: 15579415
Pediatr Res. 2000 May;47(5):578-85
pubmed: 10813580
Environ Health Perspect. 2013 Apr;121(4):514-20
pubmed: 23416456
Int J Obes (Lond). 2015 Oct;39(10):1437-42
pubmed: 26055075
Epidemiology. 2019 Sep;30(5):756-767
pubmed: 31373935
Environ Health Perspect. 2016 Apr;124(4):507-13
pubmed: 26308089
J Pediatr Endocrinol Metab. 2019 Nov 26;32(11):1235-1239
pubmed: 31483758
Environ Int. 2018 Apr;113:231-239
pubmed: 29453090
Environ Int. 2018 Mar;112:243-250
pubmed: 29294443
Semin Ultrasound CT MR. 2008 Apr;29(2):136-46
pubmed: 18450139
Curr Environ Health Rep. 2021 Jun;8(2):98-112
pubmed: 34046860
Anal Chem. 2005 Aug 15;77(16):5407-13
pubmed: 16097788
Environ Int. 2016 Sep;94:531-537
pubmed: 27320326
Obes Rev. 2005 May;6(2):143-54
pubmed: 15836465
J Steroid Biochem Mol Biol. 2018 Apr;178:322-332
pubmed: 29410257
Environ Sci Pollut Res Int. 2019 Dec;26(35):35670-35686
pubmed: 31728953
J Clin Endocrinol Metab. 2021 May 13;106(6):1684-1691
pubmed: 33616653
Int J Obes (Lond). 2018 Jan;42(1):20-27
pubmed: 28925411
Toxicol Appl Pharmacol. 2017 Aug 15;329:48-57
pubmed: 28527915
Ultrasound Obstet Gynecol. 2013 Feb;41(2):136-45
pubmed: 22648955
Obstet Gynecol. 2014 Aug;124(2 Pt 1):257-264
pubmed: 25004346
JAMA Pediatr. 2020 Dec 1;174(12):1141-1148
pubmed: 32804197
Environ Health Perspect. 2020 Apr;128(4):47004
pubmed: 32255670
Epidemiology. 2016 May;27(3):378-88
pubmed: 27035688
Int J Epidemiol. 2016 Dec 1;45(6):1887-1894
pubmed: 28089956
Sci Total Environ. 2020 Feb 10;703:134720
pubmed: 31731171
Nutrients. 2020 Feb 19;12(2):
pubmed: 32092855
Obstet Gynecol. 1992 Jan;79(1):46-50
pubmed: 1727584
J Clin Endocrinol Metab. 2021 Jun 16;106(7):e2633-e2638
pubmed: 33720358
Environ Sci Technol. 2020 Oct 20;54(20):13157-13166
pubmed: 32940456
Environ Health Perspect. 2022 Apr;130(4):47006
pubmed: 35452257
Int J Environ Res Public Health. 2021 Feb 04;18(4):
pubmed: 33557227
Environ Res. 2018 Apr;162:308-317
pubmed: 29407762
Environ Sci Technol. 2021 Aug 17;55(16):11155-11165
pubmed: 34347462
Best Pract Res Clin Obstet Gynaecol. 2012 Oct;26(5):575-91
pubmed: 22789608
Int J Obes (Lond). 2016 Jul;40(7):1056-62
pubmed: 27133623
Adv Nutr. 2019 Sep 1;10(5):803-815
pubmed: 31144713
Am J Epidemiol. 2018 Mar 1;187(3):568-575
pubmed: 29165572
Curr Probl Pediatr Adolesc Health Care. 2008 Feb;38(2):34-49
pubmed: 18237855
Prog Lipid Res. 2021 Jan;81:101082
pubmed: 33383022
Am J Clin Nutr. 2015 Feb;101(2):302-9
pubmed: 25646327
Environ Health Perspect. 2016 Feb;124(2):220-7
pubmed: 26219104
Health Psychol. 2008 Mar;27(2):194-203
pubmed: 18377138
Int J Environ Res Public Health. 2021 Apr 29;18(9):
pubmed: 33946657
Reprod Toxicol. 2017 Oct;73:175-183
pubmed: 28844799
Reprod Toxicol. 2017 Mar;68:130-144
pubmed: 27496714
Nutrients. 2020 Sep 08;12(9):
pubmed: 32911676
Int J Environ Res Public Health. 2020 Dec 15;17(24):
pubmed: 33333918
Environ Int. 2016 May;91:350-6
pubmed: 27037776
Ann Nutr Metab. 2017;70(3):236-240
pubmed: 28301849
Am J Clin Nutr. 2004 Apr;79(4):653-60
pubmed: 15051611
Int J Obes (Lond). 2020 Nov;44(11):2225-2235
pubmed: 32920592
J Nutr Biochem. 2015 Nov;26(11):1208-20
pubmed: 26188368
Environ Health. 2018 Mar 5;17(1):24
pubmed: 29506550
Am J Epidemiol. 2011 Nov 1;174(9):1062-8
pubmed: 21946386
Environ Health. 2019 May 8;18(1):43
pubmed: 31068204
Environ Int. 2022 Apr;162:107150
pubmed: 35247685
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Dec 1;860(1):106-12
pubmed: 17997365
Environ Sci Technol. 2022 May 17;56(10):6560-6573
pubmed: 35536918