Caffeic acid's role in mitigating polycystic ovary syndrome by countering apoptosis and ER stress triggered by oxidative stress.
Caffeic acid
Dehydroepiandrosterone (DHEA)
Hyperandrogenemia
Oxidative stress, hypergly-cemia
Polycystic ovary syndrome (PCOS)
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
01
06
2023
revised:
11
08
2023
accepted:
12
08
2023
medline:
18
9
2023
pubmed:
25
8
2023
entrez:
24
8
2023
Statut:
ppublish
Résumé
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that affects women of reproductive age, characterized by androgen-induced oxidative stress leading to several metabolic disorders. In this study, we investigated the potential therapeutic effect of caffeic acid on PCOS and its underlying molecular mechanism. We used a human ovarian granulosa cell line (KGN cells) induced by hydrogen peroxide (H
Identifiants
pubmed: 37619480
pii: S0753-3322(23)01118-6
doi: 10.1016/j.biopha.2023.115327
pii:
doi:
Substances chimiques
caffeic acid
U2S3A33KVM
Hydrogen Peroxide
BBX060AN9V
Dehydroepiandrosterone
459AG36T1B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115327Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome.