Antibody-mediated NK cell activation as a correlate of immunity against influenza infection.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
24 08 2023
24 08 2023
Historique:
received:
17
02
2023
accepted:
07
08
2023
medline:
28
8
2023
pubmed:
25
8
2023
entrez:
24
8
2023
Statut:
epublish
Résumé
Antibodies play a critical role in protection against influenza; yet titers and viral neutralization represent incomplete correlates of immunity. Instead, the ability of antibodies to leverage the antiviral power of the innate immune system has been implicated in protection from and clearance of influenza infection. Here, post-hoc analysis of the humoral immune response to influenza is comprehensively profiled in a cohort of vaccinated older adults (65 + ) monitored for influenza infection during the 2012/2013 season in the United States (NCT: 01427309). While robust humoral immune responses arose against the vaccine and circulating strains, influenza-specific antibody effector profiles differed in individuals that later became infected with influenza, who are deficient in NK cell activating antibodies to both hemagglutinin and neuraminidase, compared to individuals who remained uninfected. Furthermore, NK cell activation was strongly associated with the NK cell senescence marker CD57, arguing for the need for selective induction of influenza-specific afucosylated NK activating antibodies in older adults to achieve protection. High dose vaccination, currently used for older adults, was insufficient to generate this NK cell-activating humoral response. Next generation vaccines able to selectively bolster NK cell activating antibodies may be required to achieve protection in the setting of progressively senescent NK cells.
Identifiants
pubmed: 37620306
doi: 10.1038/s41467-023-40699-8
pii: 10.1038/s41467-023-40699-8
pmc: PMC10449820
doi:
Substances chimiques
Influenza Vaccines
0
Antibodies, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
5170Subventions
Organisme : NIAID NIH HHS
ID : R01 AI146785
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI165072
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG067988
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI137057
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG048023
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI153098
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI142790
Pays : United States
Informations de copyright
© 2023. Springer Nature Limited.
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