Investigation of microstructural failure in the human cornea through fracture tests.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 08 2023
24 08 2023
Historique:
received:
23
03
2023
accepted:
08
08
2023
medline:
28
8
2023
pubmed:
25
8
2023
entrez:
24
8
2023
Statut:
epublish
Résumé
Fracture toughness of the human cornea is one of the critical parameters in suture-involved corneal surgeries and the development of bioengineered mimetics of the human cornea. The present article systematically studied the fracture characteristics of the human cornea to evaluate its resistance to tear in the opening (Mode-I) and trouser tear mode (Mode-III). Tear experiments reveal the dependency of the fracture behavior on the notch size and its location created in the corneal specimens. The findings indicate lamellar tear and collagen fiber pull-out as a failure mechanism in trouser tear and opening mode tests, respectively. Experimental results have shown a localized variation of tear behavior in trouser tear mode and indicated an increasing resistance to tear from the corneal center to the periphery. This article demonstrated the complications of evaluating fracture toughness in opening mode and showed that the limbus was weaker than the cornea and sclera against tearing. The overall outcomes of the present study help in designing experiments to understand the toughness of the diseased tissues, understanding the effect of the suturing location and donor placement, and creating numerical models to study parameters affecting corneal replacement surgery.
Identifiants
pubmed: 37620375
doi: 10.1038/s41598-023-40286-3
pii: 10.1038/s41598-023-40286-3
pmc: PMC10449857
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13876Informations de copyright
© 2023. Springer Nature Limited.
Références
Diagnostics (Basel). 2022 Jan 19;12(2):
pubmed: 35204325
Interface Focus. 2019 Oct 6;9(5):20190010
pubmed: 31485307
Eye (Lond). 1989;3 ( Pt 2):101-8
pubmed: 2695343
Exp Eye Res. 1980 Oct;31(4):435-41
pubmed: 7449878
Arch Ophthalmol. 2010 Jan;128(1):114-6
pubmed: 20065227
Acta Ophthalmol. 2009 Feb;87(1):48-51
pubmed: 18547280
Am J Ophthalmol. 2012 Mar;153(3):412-8
pubmed: 22000702
Biomaterials. 2013 Sep;34(28):6748-59
pubmed: 23764112
Acta Biomater. 2013 Jul;9(7):7326-34
pubmed: 23470550
PLoS One. 2015 Jul 28;10(7):e0132902
pubmed: 26218188
J R Soc Interface. 2005 Jun 22;2(3):177-85
pubmed: 16849178
Acta Biomater. 2021 Aug;130:317-331
pubmed: 34119714
Int J Mol Sci. 2021 Jan 28;22(3):
pubmed: 33525484
Nat Commun. 2015 Mar 27;6:6649
pubmed: 25812485
Arch Ophthalmol. 1968 Jan;79(1):28-30
pubmed: 5635083
Interface Focus. 2019 Oct 6;9(5):20190012
pubmed: 31485308
Exp Eye Res. 2008 May;86(5):783-90
pubmed: 18396276
J Cataract Refract Surg. 2003 Sep;29(9):1780-5
pubmed: 14522301
J Mech Behav Biomed Mater. 2022 Jan;125:104958
pubmed: 34814077
J Mech Behav Biomed Mater. 2014 Jun;34:116-23
pubmed: 24566382
J Biomech. 2010 Jun 18;43(9):1823-6
pubmed: 20211469
Mol Vis. 2009;15:378-85
pubmed: 19234631
Exp Eye Res. 2006 Oct;83(4):709-20
pubmed: 16720023
Cornea. 1995 Nov;14(6):545-6
pubmed: 8575170
J Biomech Eng. 1992 May;114(2):202-15
pubmed: 1602763
Surv Ophthalmol. 2000 Mar-Apr;44(5):367-408
pubmed: 10734239
J Biomech. 2001 Apr;34(4):533-7
pubmed: 11266678
Biomech Model Mechanobiol. 2021 Aug;20(4):1353-1363
pubmed: 33877503
Mater Sci Eng C Mater Biol Appl. 2017 Aug 1;77:212-218
pubmed: 28532023
Structure. 2004 Feb;12(2):249-56
pubmed: 14962385
Optom Vis Sci. 2008 Jun;85(6):445-50
pubmed: 18521022
J Mech Behav Biomed Mater. 2020 Sep;109:103848
pubmed: 32543412
Surv Ophthalmol. 2018 Nov - Dec;63(6):851-861
pubmed: 29857022
Adv Healthc Mater. 2021 Oct;10(20):e2100972
pubmed: 34369098
Exp Eye Res. 1998 Jan;66(1):97-103
pubmed: 9533835
Bioengineering (Basel). 2021 Oct 26;8(11):
pubmed: 34821727
J Mech Behav Biomed Mater. 2012 Feb;6:139-47
pubmed: 22301183
Indian J Ophthalmol. 2013 Aug;61(8):392-3
pubmed: 23925321
Indian J Ophthalmol. 2023 Mar;71(3):698-706
pubmed: 36872664
Mater Sci Eng C Mater Biol Appl. 2016 Dec 1;69:941-6
pubmed: 27612789
IEEE Trans Terahertz Sci Technol. 2015 Mar;5(2):170-183
pubmed: 26322247
Br J Ophthalmol. 1999 Apr;83(4):403-9
pubmed: 10434860
Curr Eye Res. 2007 Jan;32(1):11-9
pubmed: 17364730